Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0557 | 0.1501 | 0.5 |
Echinococcus granulosus | sodium channel protein | 0.0272 | 0.0509 | 0.0509 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0557 | 0.1501 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0926 | 0.278 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0557 | 0.1501 | 0.5 |
Echinococcus multilocularis | sodium channel protein | 0.0272 | 0.0509 | 0.0509 |
Brugia malayi | dihydrofolate reductase family protein | 0.0926 | 0.278 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.3007 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0926 | 0.278 | 0.278 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0926 | 0.278 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0926 | 0.278 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0557 | 0.1501 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0926 | 0.278 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.3007 | 1 | 1 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0272 | 0.0509 | 0.0509 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0557 | 0.1501 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0557 | 0.1501 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0926 | 0.278 | 0.278 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0926 | 0.278 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2938 | 0.9761 | 0.9761 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0926 | 0.278 | 1 |
Onchocerca volvulus | 0.0125 | 0 | 0.5 | |
Echinococcus multilocularis | dihydrofolate reductase | 0.0926 | 0.278 | 0.278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.