Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium:calmodulin dependent 3',5' cyclic | 0.0185 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0145 | 0.5951 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0181 | 0.9562 | 0.9562 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0181 | 0.9562 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0095 | 0.1024 | 0.1024 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0145 | 0.5951 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1024 | 0.1024 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0095 | 0.1024 | 0.1024 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0145 | 0.5951 | 0.5951 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0145 | 0.5951 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1024 | 0.1024 |
Schistosoma mansoni | thyroid hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | nuclear receptor RXR | 0.0095 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | calcium:calmodulin dependent 3'5' cyclic | 0.0185 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0095 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0181 | 0.9562 | 0.9562 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0145 | 0.5951 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0095 | 0.1024 | 0.1024 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0181 | 0.9562 | 0.9562 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0145 | 0.5951 | 0.5 |
Brugia malayi | hypothetical protein | 0.0095 | 0.1024 | 0.1024 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | steroid hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | proteasome prosome macropain | 0.0145 | 0.5951 | 0.5951 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0181 | 0.9562 | 0.9562 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0145 | 0.5951 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0095 | 0.1024 | 0.1024 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0145 | 0.5951 | 0.5951 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | thyroid hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0181 | 0.9562 | 0.9562 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0145 | 0.5951 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0181 | 0.9562 | 0.9562 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0145 | 0.5951 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0181 | 0.9562 | 0.9562 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0181 | 0.9562 | 0.9562 |
Echinococcus granulosus | FTZ F1 alpha | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0181 | 0.9562 | 0.9562 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0181 | 0.9562 | 0.9562 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0145 | 0.5951 | 0.5951 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0095 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0145 | 0.5951 | 0.5951 |
Brugia malayi | ecdysteroid receptor | 0.0181 | 0.9562 | 0.9562 |
Onchocerca volvulus | 0.0181 | 0.9562 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | nuclear receptor NHR-88 | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | PDE1B protein | 0.0185 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0181 | 0.9562 | 0.9562 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0145 | 0.5951 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | hypothetical protein | 0.0095 | 0.1024 | 0.1024 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0181 | 0.9562 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0181 | 0.9562 | 0.9562 |
Schistosoma mansoni | calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase | 0.0185 | 1 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0145 | 0.5951 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.1024 | 0.1024 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0095 | 0.1024 | 0.1024 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Brugia malayi | nuclear hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0181 | 0.9562 | 0.9562 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0145 | 0.5951 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0181 | 0.9562 | 0.9562 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0145 | 0.5951 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0181 | 0.9562 | 0.9562 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0181 | 0.9562 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0181 | 0.9562 | 0.9562 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0145 | 0.5951 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.9562 | 0.9562 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 32 ug ml-1 | Antibacterial activity against Escherichia coli ATCC 25922 after 24 hr by two-fold microdilution technique | ChEMBL. | No reference |
MIC (functional) | = 64 ug ml-1 | Microbiostatic activity against Saccharomyces cerevisiae ATCC 74212 after 48 hr by two fold microdilution technique | ChEMBL. | No reference |
MIC (functional) | = 128 ug ml-1 | Microbiostatic activity against Candida albicans ATCC 76615 after 48 hr by two-fold microdilution technique | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.