Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0018 | 0.0016 | 0.0016 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0016 | 0.001 | 0.001 |
Echinococcus granulosus | c src tyrosine kinase | 0.0018 | 0.0016 | 0.0016 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0016 | 0.0016 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3595 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.3595 | 1 | 1 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0018 | 0.0016 | 0.0016 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0016 | 0.001 | 0.001 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0016 | 0.001 | 0.001 |
Schistosoma mansoni | nck2/grb4 | 0.0016 | 0.001 | 0.001 |
Brugia malayi | SRC-1 | 0.0018 | 0.0016 | 0.0016 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3595 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3595 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.3595 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3595 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3595 | 1 | 0.5 |
Schistosoma mansoni | adapter molecule crk | 0.0016 | 0.001 | 0.001 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1375 | 0.3803 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1375 | 0.3803 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0018 | 0.0016 | 0.0016 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0435 | 0.1181 | 0.1181 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0018 | 0.0016 | 0.0016 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0018 | 0.0016 | 0.0016 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0016 | 0.001 | 0.0009 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1375 | 0.3803 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0018 | 0.0016 | 0.0016 |
Echinococcus granulosus | NCK adaptor protein | 0.0016 | 0.001 | 0.001 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0016 | 0.001 | 0.001 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0016 | 0.0016 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1375 | 0.3803 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3595 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0018 | 0.0016 | 0.0016 |
Echinococcus multilocularis | NCK adaptor protein | 0.0016 | 0.001 | 0.001 |
Schistosoma mansoni | vav2 | 0.0012 | 0.0001 | 0.0001 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0018 | 0.0016 | 0.0016 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0435 | 0.1181 | 0.1181 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0016 | 0.001 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0018 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0016 | 0.001 | 0.0009 |
Loa Loa (eye worm) | SRC-1 | 0.0018 | 0.0016 | 0.0016 |
Brugia malayi | Variant SH3 domain containing protein | 0.0016 | 0.001 | 0.0009 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0018 | 0.0016 | 0.0016 |
Schistosoma mansoni | tyrosine kinase | 0.0428 | 0.116 | 0.116 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0016 | 0.0016 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0018 | 0.0016 | 0.0016 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0018 | 0.0016 | 0.0016 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0018 | 0.0016 | 0.0016 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0018 | 0.0016 | 0.0016 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0018 | 0.0016 | 0.0016 |
Schistosoma mansoni | tyrosine kinase | 0.0018 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.001 | 0.0009 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1375 | 0.3803 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.3595 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0018 | 0.0016 | 0.0016 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0018 | 0.0016 | 0.0016 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0018 | 0.0016 | 0.0016 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0018 | 0.0016 | 0.0016 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1375 | 0.3803 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0018 | 0.0016 | 0.0016 |
Brugia malayi | Variant SH3 domain containing protein | 0.0016 | 0.001 | 0.0009 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0018 | 0.0016 | 0.0016 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0016 | 0.001 | 0.001 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.