Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Protease | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | intracisternal A-particle retropepsin (A02 family) | Get druggable targets OG5_131408 | All targets in OG5_131408 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | retroviral aspartyl protease domain-containing protein | Protease | 99 aa | 102 aa | 32.4 % |
Entamoeba histolytica | retroviral aspartyl protease domain-containing protein | Protease | 99 aa | 102 aa | 32.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3153 | 0.2483 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.8076 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8076 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3153 | 0.2483 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.8076 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.8076 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3153 | 0.2483 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.8076 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.8076 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.8076 | 1 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.8076 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3153 | 0.2483 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3153 | 0.2483 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.8076 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.3153 | 0.2483 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.8076 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.8076 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3153 | 0.2483 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8076 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3153 | 0.2483 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3153 | 0.2483 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3153 | 0.2483 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.8076 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.8076 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.3153 | 0.2483 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 24 nM | Inhibition of Human immunodeficiency virus 1 protease using Lys-Ala-Arg-Val-Leu-Phe(NO2)-Glu-Ala-Met as substrate | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.