Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Homo sapiens | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0063 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0063 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0063 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0063 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0063 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of COX1 (unknown origin) | LITERATURE. | No reference | |
Inhibition (binding) | = 20 % | Inhibition of COX2 (unknown origin) at 10 uM | ChEMBL. | No reference |
Kd (binding) | = 0.262 uM | Binding affinity to COX1 (unknown origin) | ChEMBL. | No reference |
Kd (binding) | = 0.448 uM | Binding affinity to COX2 (unknown origin) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.