Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Plasmodium falciparum | cysteine proteinase falcipain 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Plasmodium berghei | berghepain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | vivapain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | unspecified product | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium yoelii | cysteine proteinase precursor | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium vivax | unspecified product | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Plasmodium knowlesi | knowpain-1 | Get druggable targets OG5_141501 | All targets in OG5_141501 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | cathepsin B | cysteine proteinase falcipain 1 | 569 aa | 516 aa | 20.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dihydrofolate reductase | 0.0727 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0232 | 0.1773 | 0.1236 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0278 | 0.2537 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0278 | 0.2537 | 0.5 |
Plasmodium vivax | unspecified product | 0.0134 | 0.0148 | 0.0584 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0727 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0727 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.0727 | 1 | 1 |
Plasmodium vivax | vivapain-1 | 0.0134 | 0.0148 | 0.0584 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0727 | 1 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0278 | 0.2537 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0278 | 0.2537 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0727 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0278 | 0.2537 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0727 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0278 | 0.2537 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0727 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0727 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.114 | Inhibition of Plasmodium falciparum W2 cysteine protease | ChEMBL. | No reference |
IC50 (binding) | = 0.77 uM | Inhibition of Plasmodium falciparum W2 cysteine protease | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.