Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | coup transcription factor | 0.135 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0312 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.135 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0713 | 0.3863 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.135 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0312 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.135 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0312 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0428 | 0.1116 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.135 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.3863 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.135 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0637 | 0.3127 | 0.2264 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0713 | 0.3863 | 0.3092 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.135 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.135 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0713 | 0.3863 | 0.3092 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.3863 | 0.3092 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0637 | 0.3127 | 0.2264 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.135 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.135 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.135 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | hypothetical protein | 0.0713 | 0.3863 | 0.3092 |
Loa Loa (eye worm) | DR-78 | 0.0637 | 0.3127 | 0.2264 |
Schistosoma mansoni | nuclear receptor | 0.0637 | 0.3127 | 0.2264 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.135 | 1 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | nuclear receptor NHR-67 | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.135 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.3863 | 0.3092 |
Loa Loa (eye worm) | steroid hormone receptor | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | nuclear receptor RXR | 0.0637 | 0.3127 | 0.2264 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.135 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0428 | 0.1116 | 0.5 |
Brugia malayi | nuclear receptor RXR | 0.0713 | 0.3863 | 0.3092 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0312 | 0 | 0.5 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.135 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0713 | 0.3863 | 0.3092 |
Schistosoma mansoni | thyroid hormone receptor | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.135 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.135 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.135 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.135 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | nuclear receptor NHR-88 | 0.0637 | 0.3127 | 0.2264 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0637 | 0.3127 | 0.2264 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.135 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.135 | 1 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0637 | 0.3127 | 0.2264 |
Schistosoma mansoni | thyroid hormone receptor | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.135 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.3863 | 0.3092 |
Schistosoma mansoni | nuclear hormone receptor | 0.135 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0637 | 0.3127 | 0.2264 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.135 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0713 | 0.3863 | 0.3092 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.135 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0428 | 0.1116 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0713 | 0.3863 | 0.3092 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0713 | 0.3863 | 0.3092 |
Brugia malayi | tailless protein | 0.0637 | 0.3127 | 0.2264 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0312 | 0 | 0.5 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.135 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.3863 | 0.3092 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Onchocerca volvulus | 0.135 | 1 | 1 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.135 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0312 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0637 | 0.3127 | 0.2264 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.135 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0428 | 0.1116 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.135 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.135 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0637 | 0.3127 | 0.2264 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.135 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0637 | 0.3127 | 0.2264 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0637 | 0.3127 | 0.2264 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.135 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.135 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.135 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.135 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.135 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.135 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.135 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.135 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.135 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0637 | 0.3127 | 0.2264 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.135 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.135 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.135 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0637 | 0.3127 | 0.2264 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.135 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0637 | 0.3127 | 0.2264 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0713 | 0.3863 | 0.3092 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0637 | 0.3127 | 0.2264 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.135 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.135 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.135 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0637 | 0.3127 | 0.2264 |
Brugia malayi | nuclear hormone receptor | 0.135 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.135 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.