Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.0203 | 0.1487 | 0.1487 |
Echinococcus granulosus | casein kinase I delta | 0.0074 | 0.0423 | 0.0304 |
Echinococcus multilocularis | casein kinase I delta | 0.0074 | 0.0423 | 0.0304 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0181 | 0.1311 | 0.1311 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0074 | 0.0423 | 0.0423 |
Echinococcus granulosus | casein kinase i | 0.0074 | 0.0423 | 0.0304 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.036 | 0.2791 | 0.2701 |
Plasmodium falciparum | casein kinase 1 | 0.0074 | 0.0423 | 0.0424 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0074 | 0.0423 | 0.6964 |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0045 | 0.0184 | 0.0184 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0045 | 0.0184 | 0.0062 |
Echinococcus granulosus | casein kinase I alpha | 0.0074 | 0.0423 | 0.0304 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0203 | 0.1487 | 0.0937 |
Leishmania major | casein kinase, putative | 0.0074 | 0.0423 | 0.0424 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0723 | 0.5807 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0045 | 0.0184 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | thymidylate synthase | 0.0203 | 0.1487 | 0.1487 |
Echinococcus multilocularis | casein kinase I alpha | 0.0074 | 0.0423 | 0.0304 |
Echinococcus granulosus | casein kinase I alpha | 0.0074 | 0.0423 | 0.0304 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0096 | 0.0607 | 1 |
Trypanosoma brucei | casein kinase I, isoform 2 | 0.0074 | 0.0423 | 0.0424 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0045 | 0.0184 | 0.3039 |
Brugia malayi | hypothetical protein | 0.0181 | 0.1311 | 0.1311 |
Echinococcus multilocularis | serine:threonine protein kinase TAO1 | 0.0181 | 0.1311 | 0.1203 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0723 | 0.5807 | 1 |
Onchocerca volvulus | 0.0203 | 0.1487 | 1 | |
Trypanosoma cruzi | casein kinase, putative | 0.0074 | 0.0423 | 0.0728 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1229 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0045 | 0.0184 | 0.0184 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0074 | 0.0423 | 0.6964 |
Trypanosoma cruzi | casein kinase, putative | 0.0074 | 0.0423 | 0.0728 |
Trichomonas vaginalis | STE family protein kinase | 0.0038 | 0.0123 | 0.2022 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0894 | 0.0894 |
Loa Loa (eye worm) | hypothetical protein | 0.0131 | 0.0894 | 0.0894 |
Trypanosoma cruzi | casein kinase, putative | 0.0074 | 0.0423 | 0.0728 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0045 | 0.0184 | 0.0062 |
Brugia malayi | Dihydrofolate reductase | 0.1229 | 1 | 1 |
Onchocerca volvulus | 0.0074 | 0.0423 | 0.0206 | |
Echinococcus multilocularis | casein kinase I alpha | 0.0074 | 0.0423 | 0.0304 |
Loa Loa (eye worm) | CK1/CK1/CK1-A protein kinase | 0.0074 | 0.0423 | 0.0423 |
Brugia malayi | Protein kinase domain | 0.0038 | 0.0123 | 0.0123 |
Entamoeba histolytica | casein kinase, putative | 0.0074 | 0.0423 | 1 |
Plasmodium vivax | casein kinase 1, putative | 0.0074 | 0.0423 | 0.0424 |
Schistosoma mansoni | protein kinase | 0.036 | 0.2791 | 0.2791 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0723 | 0.5807 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0203 | 0.1487 | 0.1487 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0723 | 0.5807 | 1 |
Entamoeba histolytica | casein kinase 1, putative | 0.0074 | 0.0423 | 1 |
Schistosoma mansoni | protein kinase | 0.0038 | 0.0123 | 0.0123 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0723 | 0.5807 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1229 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0203 | 0.1487 | 0.1382 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0045 | 0.0184 | 0.0062 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0096 | 0.0607 | 0.1045 |
Brugia malayi | Cam kinase protein 1 | 0.0045 | 0.0184 | 0.0184 |
Loa Loa (eye worm) | STE/STE20/TAO protein kinase | 0.0181 | 0.1311 | 0.1311 |
Trichomonas vaginalis | STE family protein kinase | 0.0038 | 0.0123 | 0.2022 |
Brugia malayi | hypothetical protein | 0.0096 | 0.0607 | 0.0607 |
Trypanosoma cruzi | casein kinase, putative | 0.0074 | 0.0423 | 0.0728 |
Echinococcus multilocularis | casein kinase I delta | 0.0074 | 0.0423 | 0.0304 |
Schistosoma mansoni | protein kinase | 0.036 | 0.2791 | 0.2791 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase subunit type II alpha | 0.0314 | 0.2414 | 0.2414 |
Brugia malayi | casein kinase I | 0.0074 | 0.0423 | 0.0423 |
Trypanosoma cruzi | casein kinase, putative | 0.0074 | 0.0423 | 0.0728 |
Schistosoma mansoni | protein kinase | 0.036 | 0.2791 | 0.2791 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.0071 | 0.04 | 0.0689 |
Toxoplasma gondii | casein kinase I | 0.0074 | 0.0423 | 0.0424 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1229 | 1 | 1 |
Onchocerca volvulus | 0.0131 | 0.0894 | 0.4541 | |
Brugia malayi | Calcium/calmodulin-dependent protein kinase type II alpha chain | 0.0314 | 0.2414 | 0.2414 |
Trypanosoma cruzi | casein kinase, delta isoform, putative | 0.0074 | 0.0423 | 0.0728 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0999 | 0.0999 |
Schistosoma mansoni | protein kinase | 0.0038 | 0.0123 | 0.0123 |
Schistosoma mansoni | protein kinase | 0.0074 | 0.0423 | 0.0423 |
Echinococcus granulosus | serine:threonine protein kinase TAO1 | 0.0181 | 0.1311 | 0.1203 |
Echinococcus multilocularis | thymidylate synthase | 0.0203 | 0.1487 | 0.1382 |
Echinococcus granulosus | calcium dependent protein kinase | 0.0043 | 0.0162 | 0.004 |
Trichomonas vaginalis | STE family protein kinase | 0.0038 | 0.0123 | 0.2022 |
Giardia lamblia | Kinase, CK1 Casein kinase | 0.0074 | 0.0423 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.01 | 0.01 |
Entamoeba histolytica | protein kinase, putative | 0.0045 | 0.0184 | 0.2057 |
Entamoeba histolytica | protein kinase, putative | 0.0045 | 0.0184 | 0.2057 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0045 | 0.0184 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0184 | 0.0184 |
Echinococcus granulosus | casein kinase I alpha | 0.0074 | 0.0423 | 0.0304 |
Loa Loa (eye worm) | hypothetical protein | 0.0138 | 0.0953 | 0.0953 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.036 | 0.2791 | 0.2701 |
Echinococcus granulosus | dihydrofolate reductase | 0.1229 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1229 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1229 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1229 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1229 | 1 | 1 |
Echinococcus multilocularis | casein kinase I alpha | 0.0074 | 0.0423 | 0.0304 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0035 | 0.01 | 0.1654 |
Loa Loa (eye worm) | calcium/calmodulin-dependent protein kinase ID | 0.0045 | 0.0184 | 0.0184 |
Brugia malayi | Serine/threonine-protein kinase SULU | 0.0181 | 0.1311 | 0.1311 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0045 | 0.0184 | 0.0062 |
Echinococcus granulosus | casein kinase I delta | 0.0074 | 0.0423 | 0.0304 |
Trichomonas vaginalis | STE family protein kinase | 0.0038 | 0.0123 | 0.2022 |
Echinococcus multilocularis | calcium dependent protein kinase | 0.0043 | 0.0162 | 0.004 |
Loa Loa (eye worm) | CAMK/CAMK2 protein kinase | 0.0045 | 0.0184 | 0.0184 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0074 | 0.0423 | 0.0423 |
Brugia malayi | casein kinase 1, delta | 0.0074 | 0.0423 | 0.0423 |
Trichomonas vaginalis | CK1 family protein kinase | 0.0074 | 0.0423 | 0.6964 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0723 | 0.5807 | 1 |
Echinococcus multilocularis | casein kinase i | 0.0074 | 0.0423 | 0.0304 |
Loa Loa (eye worm) | CK1/CK1/CK1-D protein kinase | 0.0074 | 0.0423 | 0.0423 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.