Detailed information for compound 181472

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 551.392 | Formula: C16H19BrN6O7S2
  • H donors: 3 H acceptors: 7 LogP: -2.21 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: BrCCO/N=C(\c1csc(n1)N)/C(=O)N[C@H]1CN2N(C1=O)C(=C(C2)S(=O)(=O)CC)C(=O)O
  • InChi: 1S/C16H19BrN6O7S2/c1-2-32(28,29)10-6-22-5-8(14(25)23(22)12(10)15(26)27)19-13(24)11(21-30-4-3-17)9-7-31-16(18)20-9/h7-8H,2-6H2,1H3,(H2,18,20)(H,19,24)(H,26,27)/b21-11+/t8-/m0/s1
  • InChiKey: UVCDLXCNSOKSLR-ZKJCPEAXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.013 0.0119
Schistosoma mansoni neuropeptide receptor 0.0043 0.013 0.0119
Echinococcus multilocularis G-protein coupled receptor, putative 0.0043 0.013 0.0119
Loa Loa (eye worm) melatonin receptor type 1A 0.0043 0.013 0.0218
Echinococcus multilocularis serotonin receptor 0.0043 0.013 0.0119
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0436 0.0425
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0043 0.013 0.0218
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.004 0.011 0.5
Toxoplasma gondii microneme protein MIC2 0.0035 0.0081 0.2396
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1105 0.2015
Echinococcus multilocularis g protein coupled receptor 0.0043 0.013 0.0119
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.004 0.011 0.0098
Schistosoma mansoni hypothetical protein 0.0139 0.0699 0.0688
Brugia malayi hypothetical protein 0.0061 0.0232 0.0407
Brugia malayi Serotonin receptor 0.0043 0.013 0.0218
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.1082 0.1973
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1273 0.3861
Onchocerca volvulus 0.0043 0.013 0.0749
Plasmodium falciparum subtilisin-like protease 1 0.004 0.011 0.218
Echinococcus multilocularis c4b binding protein beta chain 0.0061 0.0232 0.0221
Brugia malayi GnHR receptor homolog 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0243
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1257 0.1247
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0043 0.013 0.0119
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0043 0.013 0.0119
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.004 0.011 0.0098
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0043 0.013 0.0218
Schistosoma mansoni amine GPCR 0.0043 0.013 0.0119
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.013 0.0119
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0043 0.013 0.0218
Trichomonas vaginalis cyclins, putative 0.005 0.0168 0.0436
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Brugia malayi Subtilase family protein 0.004 0.011 0.0181
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.013 0.0119
Schistosoma mansoni hypothetical protein 0.0043 0.013 0.0119
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0035 0.0081 0.0069
Schistosoma mansoni amine GPCR 0.0043 0.013 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Brugia malayi putative neuropeptide receptor 0.0043 0.013 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Echinococcus granulosus 7tm_1 domain containing protein 0.0043 0.013 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0043 0.013 0.0119
Trichomonas vaginalis WD repeat domain, putative 0.029 0.1595 0.4857
Trichomonas vaginalis cyclins, putative 0.005 0.0168 0.0436
Trichomonas vaginalis cyclin B, putative 0.005 0.0168 0.0436
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.004 0.011 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0043 0.013 0.0119
Toxoplasma gondii rhoptry neck protein RON1 0.0061 0.0232 0.7707
Echinococcus multilocularis g-protein coupled receptor 0.0043 0.013 0.0119
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Echinococcus granulosus g protein coupled receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus GPCR family 2 0.0064 0.0255 0.0243
Schistosoma mansoni neuropeptide receptor 0.0043 0.013 0.0119
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.013 0.0119
Schistosoma mansoni biogenic amine receptor 0.0043 0.013 0.0119
Brugia malayi hypothetical protein 0.0061 0.0232 0.0407
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0061 0.0049
Trypanosoma cruzi CYC2-like cyclin, putative 0.005 0.0168 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0168 0.0289
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0081 0.0848
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0122 0.0476
Onchocerca volvulus 0.0043 0.013 0.0749
Echinococcus multilocularis cyclins 0.0031 0.0057 0.0046
Brugia malayi Will die slowly protein 0.029 0.1595 0.2918
Trichomonas vaginalis cyclin D, putative 0.0031 0.0057 0.0091
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0043 0.013 0.0119
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.004 0.0029
Schistosoma mansoni amine GPCR 0.0043 0.013 0.0119
Echinococcus granulosus orexin receptor type 2 0.0043 0.013 0.0119
Echinococcus granulosus peptide allatostatin:somatostatin 0.0043 0.013 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Echinococcus granulosus cyclin B3 1 0.0031 0.0057 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0243
Plasmodium vivax circumsporozoite- and TRAP-related protein, putative 0.0035 0.0081 0.0848
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Trichomonas vaginalis cyclin B, putative 0.005 0.0168 0.0436
Onchocerca volvulus 0.0043 0.013 0.0749
Schistosoma mansoni growth hormone secretagogue receptor 0.0043 0.013 0.0119
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0035 0.0081 0.0127
Schistosoma mansoni neuropeptide receptor 0.0043 0.013 0.0119
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Brugia malayi celfurPC protein 0.0754 0.436 0.8016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0061 0.0049
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0122 0.0292
Brugia malayi Dopamine receptor protein 1 0.0043 0.013 0.0218
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Brugia malayi Immunoglobulin I-set domain containing protein 0.0035 0.0081 0.0127
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0043 0.013 0.0119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.013 0.0119
Echinococcus multilocularis neuropeptide FF receptor 2 0.0043 0.013 0.0119
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0043 0.013 0.0218
Onchocerca volvulus 0.005 0.0168 0.099
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus neuropeptide receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0233 0.1257 0.2295
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0035 0.0081 0.0165
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0061 0.0049
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0043 0.013 0.0218
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0061 0.1691
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0568 0.3254 0.3246
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0043 0.013 0.0218
Echinococcus granulosus cyclins 0.0031 0.0057 0.0046
Onchocerca volvulus 0.0061 0.0232 0.1394
Loa Loa (eye worm) von Willebrand factor domain-containing protein 0.0035 0.0081 0.0127
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0061 0.0049
Toxoplasma gondii rhoptry neck protein RON9 0.0061 0.0232 0.7707
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.013 0.0218
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.004 0.011 0.0428
Onchocerca volvulus 0.0043 0.013 0.0749
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0367 0.2054 0.3766
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0181 0.0948 0.2853
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0122 0.2085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0638 0.0627
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Trichomonas vaginalis cyclins, putative 0.005 0.0168 0.0436
Echinococcus multilocularis serotonin receptor 0.0043 0.013 0.0119
Echinococcus multilocularis cyclins 0.0031 0.0057 0.0046
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.013 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Brugia malayi sulfakinin receptor protein 0.0043 0.013 0.0218
Echinococcus multilocularis sex peptide receptor 0.0043 0.013 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0061 0.0238
Entamoeba histolytica cyclin, putative 0.005 0.0168 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Brugia malayi hypothetical protein 0.0061 0.0232 0.0407
Onchocerca volvulus 0.0035 0.0081 0.0437
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.004 0.011 0.0181
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0221 0.1186 0.359
Echinococcus multilocularis neuropeptide s receptor 0.0043 0.013 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.013 0.0119
Schistosoma mansoni cyclin B 0.005 0.0168 0.0157
Schistosoma mansoni alpha-1 adrenergic receptor 0.0043 0.013 0.0119
Echinococcus multilocularis membrane bound transcription factor site 1 0.004 0.011 0.0098
Brugia malayi putative neuropeptide receptor NPR1 0.0043 0.013 0.0218
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0072 0.0298 0.0286
Brugia malayi hypothetical protein 0.0035 0.0081 0.0127
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Onchocerca volvulus 0.0035 0.0081 0.0437
Echinococcus multilocularis neuropeptide receptor 0.0043 0.013 0.0119
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0035 0.0081 0.0069
Echinococcus granulosus neuropeptide receptor A26 0.0043 0.013 0.0119
Brugia malayi endoprotease bli-4 precursor 0.0935 0.5437 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0057 0.0091
Echinococcus granulosus cyclins 0.0031 0.0057 0.0046
Onchocerca volvulus 0.0043 0.013 0.0749
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0168 0.0289
Entamoeba histolytica hypothetical protein 0.0035 0.0081 0.2123
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Onchocerca volvulus 0.0043 0.013 0.0749
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Giardia lamblia Hypothetical protein 0.0031 0.0057 0.0294
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Plasmodium falciparum circumsporozoite- and TRAP-related protein 0.0035 0.0081 0.0981
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0061 0.0232 0.0407
Plasmodium vivax dynein-related AAA-type ATPase, putative 0.0035 0.0081 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.004 0.011 0.0254
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.005 0.0168 1
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.1082 0.1973
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus g protein coupled receptor 0.0043 0.013 0.0119
Trichomonas vaginalis cyclin B, putative 0.0031 0.0057 0.0091
Echinococcus granulosus c4b binding protein beta chain 0.0061 0.0232 0.0221
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0243
Onchocerca volvulus 0.0061 0.0232 0.1394
Echinococcus multilocularis cyclin b3 0.0031 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.004 0.011 0.0181
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Brugia malayi Dopamine receptor 0.0043 0.013 0.0218
Onchocerca volvulus 0.0236 0.1273 0.797
Onchocerca volvulus 0.0043 0.013 0.0749
Echinococcus granulosus Furin 1 0.0221 0.1186 0.1176
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.013 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) endoprotease bli-4 0.0935 0.5437 1
Echinococcus granulosus protein will die slowly 0.029 0.1595 0.1585
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0031 0.0057 0.0046
Onchocerca volvulus 0.0043 0.013 0.0749
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.004 0.011 1
Mycobacterium leprae Possible secreted protease 0.004 0.011 0.5
Onchocerca volvulus 0.0035 0.0081 0.0437
Toxoplasma gondii subtilisin SUB8 0.004 0.011 0.3406
Onchocerca volvulus 0.0035 0.0081 0.0437
Schistosoma mansoni biogenic amine (5HT) receptor 0.0043 0.013 0.0119
Plasmodium vivax SET domain protein, putative 0.0072 0.0298 1
Toxoplasma gondii histone lysine methyltransferase SET8 0.0072 0.0298 1
Trichomonas vaginalis cyclins, putative 0.0031 0.0057 0.0091
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.013 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Brugia malayi RE15519p 0.0043 0.013 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0255 0.0243
Brugia malayi G-protein coupled receptor 0.0043 0.013 0.0218
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.013 0.0119
Plasmodium vivax subtilisin-like protease 2, putative 0.004 0.011 0.2064
Schistosoma mansoni site-1 peptidase (S08 family) 0.004 0.011 0.0098
Schistosoma mansoni hypothetical protein 0.0043 0.013 0.0119
Plasmodium falciparum subtilisin-like protease 3 0.004 0.011 0.218
Brugia malayi AKH receptor 0.0043 0.013 0.0218
Onchocerca volvulus 0.004 0.011 0.0619
Onchocerca volvulus 0.0032 0.0061 0.031
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Echinococcus multilocularis cyclin B 0.005 0.0168 0.0157
Toxoplasma gondii subtilisin SUB10 0.004 0.011 0.3406
Schistosoma mansoni amine GPCR 0.0043 0.013 0.0119
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.013 0.0119
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0656 0.3774 0.6935
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Echinococcus multilocularis orexin receptor type 2 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0255 0.0243
Loa Loa (eye worm) TYRA-2 protein 0.0043 0.013 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Brugia malayi ORL1-like opioid receptor 0.0043 0.013 0.0218
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0061 0.0049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Trichomonas vaginalis cyclins, putative 0.005 0.0168 0.0436
Brugia malayi follicle stimulating hormone receptor 0.0043 0.013 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0221 0.1186 0.359
Onchocerca volvulus 0.0035 0.0081 0.0437
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Brugia malayi pregnancy-associated plasma protein-A 0.0061 0.0232 0.0407
Schistosoma mansoni biogenic amine receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Schistosoma mansoni neuropeptide receptor 0.0043 0.013 0.0119
Echinococcus multilocularis cyclins 0.0031 0.0057 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.0091
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0043 0.013 0.0218
Echinococcus multilocularis G protein coupled receptor kinase 1 0.0085 0.0377 0.0366
Schistosoma mansoni hypothetical protein 0.0035 0.0081 0.0069
Schistosoma mansoni adenoreceptor 0.0043 0.013 0.0119
Loa Loa (eye worm) proprotein convertase 2 0.0221 0.1186 0.2165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Echinococcus multilocularis fmrfamide receptor 0.0043 0.013 0.0119
Brugia malayi hypothetical protein 0.0061 0.0232 0.0407
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.004 0.011 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.004 0.011 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0061 0.0049
Echinococcus granulosus hypothetical protein 0.0043 0.013 0.0119
Toxoplasma gondii subtilisin SUB11 0.004 0.011 0.3406
Echinococcus multilocularis g protein coupled receptor 0.0043 0.013 0.0119
Schistosoma mansoni cyclin B3 0.0031 0.0057 0.0046
Brugia malayi G-protein coupled receptor 0.0043 0.013 0.0218
Echinococcus multilocularis cyclins 0.0031 0.0057 0.0046
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0043 0.013 0.0749
Schistosoma mansoni hypothetical protein 0.0064 0.0255 0.0243
Brugia malayi Sushi domain 0.0061 0.0232 0.0407
Trypanosoma brucei subtilisin peptidase 0.004 0.011 0.0428
Giardia lamblia Furin precursor putative serine protease 0.0181 0.0948 0.4888
Brugia malayi neuropeptide F receptor 0.0043 0.013 0.0218
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0072 0.0298 0.0286
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Trichomonas vaginalis cyclin B3, putative 0.0031 0.0057 0.0091
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0122 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0517 0.2946 0.2938
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.004 0.011 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0043 0.013 0.0119
Leishmania major cyclin 0.005 0.0168 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Schistosoma mansoni survival motor neuron protein 0.0047 0.0154 0.0143
Onchocerca volvulus 0.0035 0.0081 0.0437
Leishmania major subtilisin-like serine peptidase 0.004 0.011 0.6508
Toxoplasma gondii subtilisin SUB5 0.004 0.011 0.3406
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0061 0.0238
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus multilocularis dro:myosuppressin receptor 0.0043 0.013 0.0119
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Echinococcus granulosus neuropeptide s receptor 0.0043 0.013 0.0119
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0043 0.013 0.0119
Schistosoma mansoni site-1 peptidase (S08 family) 0.004 0.011 0.0098
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0568 0.3254 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.011 0.0254
Schistosoma mansoni biogenic amine receptor 0.0043 0.013 0.0119
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Schistosoma mansoni hypothetical protein 0.0047 0.0154 0.0143
Echinococcus multilocularis GPCR, family 2 0.0064 0.0255 0.0243
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus biogenic amine 5HT receptor 0.0043 0.013 0.0119
Echinococcus granulosus fmrfamide receptor 0.0043 0.013 0.0119
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0043 0.013 0.0119
Schistosoma mansoni histamine h1 receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus C type lectin domian containing protein 0.0061 0.0232 0.0221
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0221 0.1186 0.359
Echinococcus granulosus beta-adrenergic receptor kinase 0.0095 0.0436 0.0425
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0154 0.0263
Echinococcus granulosus dna polymerase kappa 0.0042 0.0122 0.011
Giardia lamblia G2/mitotic-specific cyclin B 0.005 0.0168 0.0868
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0436 0.0425
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Onchocerca volvulus 0.0061 0.0232 0.1394
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0699 0.1267
Schistosoma mansoni opsin-like receptor 0.0043 0.013 0.0119
Echinococcus multilocularis g protein coupled receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0656 0.3774 0.6935
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.013 0.0119
Trypanosoma brucei RNA helicase, putative 0.0451 0.2558 1
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0095 0.0436 0.0782
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0778 0.0768
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0043 0.013 0.0119
Echinococcus multilocularis cyclins 0.0031 0.0057 0.0046
Brugia malayi hypothetical protein 0.0061 0.0232 0.0407
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0043 0.013 0.0119
Onchocerca volvulus 0.0061 0.0232 0.1394
Entamoeba histolytica elongation factor-2 kinase, putative 0.0035 0.0081 0.2123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Echinococcus multilocularis cyclin B3 1 0.0031 0.0057 0.0046
Trypanosoma brucei unspecified product 0.0035 0.0082 0.0319
Loa Loa (eye worm) hypothetical protein 0.0064 0.0255 0.0448
Trypanosoma cruzi cyclin, putative 0.005 0.0168 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0095 0.0436 0.0425
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) neuropeptide F receptor 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.005 0.0168 0.0289
Plasmodium falciparum von Willebrand factor A domain-related protein 0.0035 0.0081 0.0981
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Schistosoma mansoni hypothetical protein 0.0035 0.0081 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Brugia malayi neuroendocrine convertase 1 precursor 0.0588 0.3369 0.6188
Echinococcus multilocularis C type lectin domian containing protein 0.0061 0.0232 0.0221
Toxoplasma gondii subtilisin SUB6 0.004 0.011 0.3406
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Toxoplasma gondii von Willebrand factor type A domain-containing protein 0.0035 0.0081 0.2396
Echinococcus granulosus neuropeptide receptor 0.0043 0.013 0.0119
Schistosoma mansoni neuropeptide f receptor 76f 0.0043 0.013 0.0119
Echinococcus granulosus sex peptide receptor 0.0043 0.013 0.0119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.004 0.011 0.0098
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Echinococcus granulosus furin 0.0935 0.5437 0.5431
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0638 0.0627
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0122 0.0292
Trichomonas vaginalis conserved hypothetical protein 0.004 0.011 0.0254
Echinococcus multilocularis G protein coupled receptor 139 0.0043 0.013 0.0119
Trichomonas vaginalis cyclin B, putative 0.005 0.0168 0.0436
Trypanosoma cruzi cyclin, putative 0.005 0.0168 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0043 0.013 0.0119
Plasmodium falciparum thrombospondin-related anonymous protein 0.0035 0.0081 0.0981
Brugia malayi Serotonin receptor 0.0043 0.013 0.0218
Echinococcus granulosus somatostatin receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Entamoeba histolytica hypothetical protein, conserved 0.0035 0.0081 0.2123
Trypanosoma brucei mitotic cyclin 6 0.005 0.0168 0.0658
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0181 0.0948 0.2853
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Schistosoma mansoni hypothetical protein 0.0181 0.0948 0.0938
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Schistosoma mansoni hypothetical protein 0.029 0.1595 0.1585
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0122 1
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Schistosoma mansoni amine GPCR 0.0043 0.013 0.0119
Onchocerca volvulus 0.0061 0.0232 0.1394
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.013 0.0119
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0181 0.0948 0.2853
Trichomonas vaginalis cyclin D, putative 0.0031 0.0057 0.0091
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0043 0.013 0.0119
Brugia malayi Pre-SET motif family protein 0.0032 0.0061 0.009
Brugia malayi GCC2 and GCC3 family protein 0.0061 0.0232 0.0407
Plasmodium vivax thrombospondin-related anonymous protein 0.0035 0.0081 0.0848
Loa Loa (eye worm) hypothetical protein 0.0935 0.5437 1
Trichomonas vaginalis conserved hypothetical protein 0.004 0.011 0.0254
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0122 0.0476
Brugia malayi G protein-coupled receptor 0.0043 0.013 0.0218
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0935 0.5437 0.5431
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0043 0.013 0.0119
Echinococcus multilocularis cyclins 0.0031 0.0057 0.0046
Echinococcus granulosus neuropeptides capa receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.013 0.0218
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0122 0.2085
Loa Loa (eye worm) subtilase 0.004 0.011 0.0181
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Echinococcus granulosus G protein coupled receptor 139 0.0043 0.013 0.0119
Trichomonas vaginalis hypothetical protein 0.0181 0.0948 0.2853
Loa Loa (eye worm) hypothetical protein 0.004 0.011 0.0181
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.013 0.0119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0255 0.0448
Echinococcus multilocularis allatostatin A receptor 0.0043 0.013 0.0119
Onchocerca volvulus 0.0043 0.013 0.0749
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0517 0.2946 0.2938
Plasmodium vivax apical sushi protein, putative 0.0061 0.0232 0.7241
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0122 0.0476
Schistosoma mansoni furin-1 (S08 family) 0.0407 0.2292 0.2283
Onchocerca volvulus 0.0047 0.0154 0.0901
Echinococcus granulosus collagen alpha 1VII chain 0.0035 0.0081 0.0069
Giardia lamblia High cysteine membrane protein Group 2 0.0347 0.194 1
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Onchocerca volvulus 0.0043 0.013 0.0749
Onchocerca volvulus 0.0043 0.013 0.0749
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0031 0.0057 0.0046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Schistosoma mansoni myosin xvIII 0.0043 0.013 0.0119
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Echinococcus granulosus cyclins 0.0031 0.0057 0.0046
Giardia lamblia Cyclin A 0.0031 0.0057 0.0294
Trichomonas vaginalis cyclin A, putative 0.005 0.0168 0.0436
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Toxoplasma gondii subtilisin SUB9 0.004 0.011 0.3406
Echinococcus multilocularis neuroendocrine convertase 2 0.0588 0.3369 0.3361
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Toxoplasma gondii subtilisin SUB2 0.004 0.011 0.3406
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0032 0.0061 0.009
Plasmodium falciparum SET domain protein, putative 0.0072 0.0298 1
Schistosoma mansoni opsin-like receptor 0.0043 0.013 0.0119
Plasmodium vivax subtilisin-like protease 1 0.004 0.011 0.2064
Trichomonas vaginalis cyclin B, putative 0.005 0.0168 0.0436
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus multilocularis protein will die slowly 0.029 0.1595 0.1585
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Echinococcus multilocularis neuropeptide Y receptor 0.0043 0.013 0.0119
Echinococcus granulosus tachykinin peptides receptor 99D 0.0043 0.013 0.0119
Brugia malayi Pre-SET motif family protein 0.0207 0.1105 0.2015
Echinococcus granulosus cyclins 0.0031 0.0057 0.0046
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0122 0.2085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.004 0.011 1
Schistosoma mansoni neuropeptide F-like receptor 0.0043 0.013 0.0119
Brugia malayi Dopamine receptor protein 2 0.0043 0.013 0.0218
Brugia malayi proprotein convertase 2 0.0588 0.3369 0.6188
Loa Loa (eye worm) G-protein coupled receptor 0.0043 0.013 0.0218
Brugia malayi larval opioid receptor 0.0043 0.013 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.013 0.0119
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0043 0.013 0.0119
Treponema pallidum 76K protein 0.0035 0.0081 0.5
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0043 0.013 0.0119
Onchocerca volvulus 0.0043 0.013 0.0749
Echinococcus multilocularis neuropeptide receptor 0.0043 0.013 0.0119
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1702 1 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0043 0.013 0.0119
Echinococcus multilocularis Furin 1 0.0221 0.1186 0.1176
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Schistosoma mansoni thyroid hormone receptor 0.0152 0.0778 0.0768
Schistosoma mansoni cyclins 0.0031 0.0057 0.0046
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0255 0.0448
Loa Loa (eye worm) CUTiclin family member 0.0035 0.0081 0.0127
Onchocerca volvulus 0.0061 0.0232 0.1394
Echinococcus granulosus tm gpcr rhodopsin 0.0043 0.013 0.0119
Schistosoma mansoni opsin-like receptor 0.0043 0.013 0.0119
Echinococcus granulosus cyclin b3 0.0031 0.0057 0.0046
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0043 0.013 0.0119
Echinococcus multilocularis neuropeptides capa receptor 0.0043 0.013 0.0119
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.004 0.011 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0568 0.3254 1
Onchocerca volvulus 0.0061 0.0232 0.1394
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0221 0.1186 0.359
Echinococcus multilocularis neuropeptide receptor A26 0.0043 0.013 0.0119
Toxoplasma gondii subtilisin SUB4 0.004 0.011 0.3406
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0122 0.011
Echinococcus granulosus neuroendocrine convertase 2 0.0588 0.3369 0.3361
Echinococcus granulosus dro:myosuppressin receptor 0.0043 0.013 0.0119
Plasmodium vivax von Willebrand factor A domain-related protein, putative 0.0035 0.0081 0.0848
Echinococcus granulosus g protein coupled receptor 0.0043 0.013 0.0119
Echinococcus granulosus allatostatin A receptor 0.0043 0.013 0.0119
Onchocerca volvulus 0.0043 0.013 0.0749
Onchocerca volvulus 0.0043 0.013 0.0749
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.013 0.0119
Brugia malayi Zona pellucida-like domain containing protein 0.0035 0.0081 0.0127
Onchocerca volvulus 0.0035 0.0081 0.0437
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0082 0.0319
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Onchocerca volvulus 0.0043 0.013 0.0749
Brugia malayi neuropeptide F receptor 0.0043 0.013 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Treponema pallidum hypothetical protein 0.0035 0.0081 0.5
Brugia malayi von Willebrand Factor 0.0035 0.0081 0.0127
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus 7TM GPCR rhodopsin 0.0043 0.013 0.0119
Echinococcus granulosus cyclins 0.0031 0.0057 0.0046
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.013 0.0119
Echinococcus granulosus g-protein coupled receptor 0.0043 0.013 0.0119
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Brugia malayi polk-prov protein 0.0032 0.0061 0.0091
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0061 0.0049
Loa Loa (eye worm) hypothetical protein 0.0061 0.0232 0.0407
Onchocerca volvulus 0.0061 0.0232 0.1394
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0072 0.0298 0.0286
Brugia malayi Protein set-1 0.0072 0.0298 0.0527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0221 0.1186 0.359
Echinococcus multilocularis somatostatin receptor 0.0043 0.013 0.0119
Brugia malayi Melatonin receptor type 1A 0.0043 0.013 0.0218
Onchocerca volvulus 0.029 0.1595 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Echinococcus multilocularis cyclins 0.0031 0.0057 0.0046
Brugia malayi G protein-coupled receptor F59B2.13 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Onchocerca volvulus 0.0043 0.013 0.0749
Schistosoma mansoni c4b-binding protein beta chain 0.0061 0.0232 0.0221
Schistosoma mansoni hypothetical protein 0.0451 0.2558 0.2549
Plasmodium vivax subtilisin-like serine protease, putative 0.004 0.011 0.2064
Echinococcus multilocularis collagen alpha 1(VII) chain 0.0035 0.0081 0.0069
Brugia malayi Tachykinin-like peptides receptor 99D 0.0043 0.013 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0043 0.013 0.0119
Brugia malayi hypothetical protein 0.0061 0.0232 0.0407
Echinococcus granulosus serotonin receptor 0.0043 0.013 0.0119
Echinococcus multilocularis fmrfamide receptor 0.0043 0.013 0.0119
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1702 1 1
Loa Loa (eye worm) von Willebrand factor type A domain-containing protein 0.0035 0.0081 0.0127
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0043 0.013 0.0119
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0043 0.013 0.0119
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Toxoplasma gondii subtilisin SUB12 0.004 0.011 0.3406
Loa Loa (eye worm) hypothetical protein 0.0139 0.0699 0.1267
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0221 0.1186 0.359
Echinococcus granulosus neuropeptide Y receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) cyclin domain-containing protein 0.0031 0.0057 0.0084
Brugia malayi Zona pellucida-like domain containing protein 0.0035 0.0081 0.0127
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.083 0.481 0.4804
Brugia malayi von Willebrand factor type A domain containing protein 0.0035 0.0081 0.0127
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0043 0.013 0.0119
Echinococcus multilocularis rhodopsin orphan GPCR 0.0043 0.013 0.0119
Brugia malayi Cyclin, N-terminal domain containing protein 0.0031 0.0057 0.0084
Loa Loa (eye worm) WD40 repeat protein 0.029 0.1595 0.2918
Echinococcus granulosus membrane bound transcription factor site 1 0.004 0.011 0.0098
Onchocerca volvulus 0.0061 0.0232 0.1394
Toxoplasma gondii subtilisin SUB7 0.004 0.011 0.3406
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0043 0.013 0.0218
Echinococcus granulosus voltage dependent calcium channel subunit 0.0035 0.0081 0.0069
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Onchocerca volvulus Neuropeptide F receptor homolog 0.0043 0.013 0.0749
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.004 0.011 0.0254
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0221 0.1186 0.1176
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.0778 0.0768
Echinococcus granulosus cyclin B 0.005 0.0168 0.0157
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.0181 0.0948 0.2853
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Trypanosoma cruzi cyclin 6, putative 0.005 0.0168 1
Plasmodium falciparum subtilisin-like protease 2 0.004 0.011 0.218
Echinococcus granulosus alpha 1A adrenergic receptor 0.0043 0.013 0.0119
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Entamoeba histolytica hypothetical protein, conserved 0.0035 0.0081 0.2123
Onchocerca volvulus 0.0061 0.0232 0.1394
Loa Loa (eye worm) CUTiclin-Like family member 0.0035 0.0081 0.0127
Plasmodium falciparum apical sushi protein 0.0061 0.0232 0.7281
Toxoplasma gondii subtilisin SUB1 0.004 0.011 0.3406
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Onchocerca volvulus 0.0043 0.013 0.0749
Brugia malayi hypothetical protein 0.0043 0.013 0.0218
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1257 0.1247
Loa Loa (eye worm) hypothetical protein 0.0043 0.013 0.0218
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0043 0.013 0.0119
Schistosoma mansoni hypothetical protein 0.0043 0.013 0.0119
Brugia malayi hypothetical protein 0.0061 0.0232 0.0407
Brugia malayi hypothetical protein 0.0233 0.1257 0.2295
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0255 0.0448
Schistosoma mansoni hypothetical protein 0.0043 0.013 0.0119
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0122 0.2085
Echinococcus granulosus G protein coupled receptor kinase 1 0.0085 0.0377 0.0366
Echinococcus multilocularis 0.0754 0.436 0.4354
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0568 0.3254 0.3246
Loa Loa (eye worm) hypothetical protein 0.0072 0.0298 0.0527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0081 0.0127
Schistosoma mansoni hypothetical protein 0.0129 0.0638 0.0627
Brugia malayi Cyclin, N-terminal domain containing protein 0.005 0.0168 0.0289

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.015 ug ml-1 In vitro antibacterial activity against Klebsiella X26 ChEMBL. 8230112
MIC (functional) = 0.06 ug ml-1 In vitro antibacterial activity against E. coli EC14 ChEMBL. 8230112
MIC (functional) = 0.06 ug ml-1 In vitro antibacterial activity against E. coli EC14 ChEMBL. 8230112
MIC (functional) = 0.125 ug ml-1 In vitro antibacterial activity against Streptococcus pneumoniae PARK ChEMBL. 8230112
MIC (functional) = 0.25 ug ml-1 In vitro antibacterial activity against Haemophilus influenza C.L ChEMBL. 8230112
MIC (functional) = 0.25 ug ml-1 In vitro antibacterial activity against Enterobacter aerogenes C32 ChEMBL. 8230112
MIC (functional) = 8 ug ml-1 In vitro antibacterial activity against Staphylococcus aureus X1.1 ChEMBL. 8230112
MIC (functional) = 8 ug ml-1 In vitro antibacterial activity against Staphylococcus epidermidis 222 ChEMBL. 8230112
MIC (functional) > 128 ug ml-1 In vitro antibacterial activity against Pseudomonas PS72 ChEMBL. 8230112

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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