Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.1222 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.1222 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0755 | 0.3805 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0743 | 0.3646 | 0.3646 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.1222 | 1 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.1083 | 0.8159 | 0.8159 |
Leishmania major | cytochrome P450 reductase, putative | 0.1083 | 0.8159 | 0.8159 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0743 | 0.3646 | 0.3646 |
Treponema pallidum | flavodoxin | 0.0468 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.1083 | 0.8159 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.1222 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0743 | 0.3646 | 0.2212 |
Trypanosoma cruzi | p450 reductase, putative | 0.1222 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.1222 | 1 | 1 |
Brugia malayi | MAP kinase sur-1 | 0.0743 | 0.3646 | 0.3646 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0468 | 0 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0743 | 0.3646 | 0.3646 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0468 | 0 | 0.5 |
Leishmania major | p450 reductase, putative | 0.1222 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1222 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.1222 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0616 | 0.1964 | 0.0151 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0743 | 0.3646 | 0.3646 |
Brugia malayi | FAD binding domain containing protein | 0.1222 | 1 | 1 |
Echinococcus multilocularis | methionine synthase reductase | 0.0755 | 0.3805 | 0.0251 |
Brugia malayi | FAD binding domain containing protein | 0.0755 | 0.3805 | 0.3805 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1222 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.1083 | 0.8159 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.1083 | 0.8159 | 0.8159 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.1222 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.1222 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.1222 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0743 | 0.3646 | 0.3646 |
Trypanosoma brucei | protein kinase, putative | 0.0743 | 0.3646 | 0.3646 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0755 | 0.3805 | 0.2407 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.1222 | 1 | 1 |
Echinococcus granulosus | methionine synthase reductase | 0.0755 | 0.3805 | 0.0251 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0743 | 0.3646 | 0.3646 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0743 | 0.3646 | 0.3646 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0755 | 0.3805 | 0.3805 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0468 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1222 | 1 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.1222 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0743 | 0.3646 | 0.3646 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0743 | 0.3646 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.1222 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0743 | 0.3646 | 0.3646 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0743 | 0.3646 | 0.3646 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.1222 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0468 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0743 | 0.3646 | 0.3646 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.1222 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.1222 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0743 | 0.3646 | 0.3646 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.1222 | 1 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0468 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.