Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Voltage-dependent L-type calcium channel subunit alpha-1C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | sodium channel protein | Voltage-dependent L-type calcium channel subunit alpha-1C | 169 aa | 145 aa | 25.5 % |
Schistosoma mansoni | cd63 antigen-like | Voltage-dependent L-type calcium channel subunit alpha-1C | 169 aa | 181 aa | 22.1 % |
Onchocerca volvulus | 60S acidic ribosomal protein P2 homolog | Voltage-dependent L-type calcium channel subunit alpha-1C | 169 aa | 144 aa | 24.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0365 | 0.1961 | 0.2041 |
Chlamydia trachomatis | biotin carboxylase | 0.0448 | 0.2678 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0493 | 0.307 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.1296 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0493 | 0.307 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.1296 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.1296 | 1 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.125 | 0.9608 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.1296 | 1 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0938 | 0.6907 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0324 | 0.161 | 0.161 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0324 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0564 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0493 | 0.307 | 0.307 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0564 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0493 | 0.307 | 0.307 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1961 | 0.2041 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0493 | 0.307 | 0.307 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0938 | 0.6907 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1791 | 0.1864 |
Echinococcus multilocularis | G1:S specific cyclin D1 | 0.0365 | 0.1961 | 0.1961 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0802 | 0.5736 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0176 | 0.0324 | 0.0324 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0176 | 0.0324 | 0.0324 |
Trichomonas vaginalis | cyclin A, putative | 0.0138 | 0 | 0.5 |
Toxoplasma gondii | pyruvate carboxylase | 0.0493 | 0.307 | 0.2839 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0176 | 0.0324 | 0.0564 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0493 | 0.307 | 0.307 |
Leishmania major | carboxylase, putative | 0.0493 | 0.307 | 0.307 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0493 | 0.307 | 1 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0176 | 0.0324 | 0.0324 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Schistosoma mansoni | cyclin d | 0.0365 | 0.1961 | 0.1961 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0493 | 0.307 | 0.307 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0493 | 0.307 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0493 | 0.307 | 1 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0324 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0221 | 0.0716 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.1296 | 1 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0493 | 0.307 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0493 | 0.307 | 0.5352 |
Schistosoma mansoni | pyruvate carboxylase | 0.0493 | 0.307 | 0.307 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0493 | 0.307 | 0.307 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0493 | 0.307 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0493 | 0.307 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0176 | 0.0324 | 0.0324 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.1296 | 1 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0493 | 0.307 | 0.5352 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0493 | 0.307 | 0.307 |
Echinococcus granulosus | G1:S specific cyclin D1 | 0.0365 | 0.1961 | 0.1961 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0221 | 0.0716 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.125 | 0.9608 | 1 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Anticonvulsant activity in Mus musculus NMRI (mouse) assessed as protection against pentylenetetrazole-induced seizures at 5 to 20 mg/kg, ip administered 30 min prior to pentylenetetrazole induction relative to vehicle-treated control | ChEMBL. | No reference | |
IC50 (binding) | = 7.38 | Inhibition of L-type calcium channel in Cavia porcellus (guinea pig) ileal SMC assessed as inhibition of 80 mM KCl-induced current | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.