Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1925 | 0.1189 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.004 | 0.0835 | 0.0835 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.0817 | 0.1125 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0093 | 0.2979 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.107 | 0.1516 |
Brugia malayi | Bromodomain containing protein | 0.0042 | 0.0922 | 0.0619 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0066 | 0.1879 | 0.2761 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.107 | 0.1516 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.004 | 0.0835 | 0.0528 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0835 | 0.1904 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0067 | 0.1925 | 0.2831 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0033 | 0.0545 | 0.0463 |
Schistosoma mansoni | DNA polymerase eta | 0.0093 | 0.2979 | 0.2918 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0032 | 0.0496 | 0.0632 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1925 | 0.1189 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0052 | 0.1307 | 0.1881 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.004 | 0.0835 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.107 | 0.1516 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0025 | 0.0218 | 0.0204 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.1307 | 0.1232 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0067 | 0.1925 | 0.5083 |
Echinococcus multilocularis | geminin | 0.0182 | 0.6582 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1925 | 0.1855 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.107 | 0.1516 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.2372 | 0.2372 |
Echinococcus multilocularis | dna polymerase kappa | 0.004 | 0.0835 | 0.1153 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Mycobacterium ulcerans | glutaminase | 0.0266 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.107 | 0.0993 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0052 | 0.1307 | 0.1232 |
Leishmania major | DNA polymerase eta, putative | 0.0065 | 0.1859 | 0.4775 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1031 | 0.1031 |
Schistosoma mansoni | glutaminase | 0.0266 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.107 | 0.0993 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1117 | 0.1117 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.0817 | 0.1125 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0093 | 0.2979 | 1 |
Echinococcus granulosus | geminin | 0.0182 | 0.6582 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.004 | 0.0835 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0067 | 0.1925 | 0.1189 |
Echinococcus granulosus | dna polymerase eta | 0.0093 | 0.2979 | 0.4454 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.6582 | 0.6552 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0067 | 0.1925 | 0.2831 |
Plasmodium vivax | SET domain protein, putative | 0.0033 | 0.0545 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0266 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0033 | 0.0545 | 0.0707 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1307 | 0.1307 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0052 | 0.1307 | 0.1881 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0067 | 0.1925 | 1 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.004 | 0.0835 | 0.1153 |
Echinococcus multilocularis | dna polymerase eta | 0.0093 | 0.2979 | 0.4454 |
Brugia malayi | Bromodomain containing protein | 0.0083 | 0.2563 | 0.2314 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0093 | 0.2979 | 0.2744 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.004 | 0.0835 | 0.1153 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.004 | 0.0835 | 0.0756 |
Trichomonas vaginalis | glutaminase, putative | 0.0266 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0093 | 0.2979 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0065 | 0.1859 | 0.4775 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.107 | 0.107 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0066 | 0.1879 | 0.2761 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0835 | 0.1904 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0067 | 0.1925 | 0.1855 |
Schistosoma mansoni | bromodomain containing protein | 0.007 | 0.2039 | 0.1971 |
Trypanosoma brucei | unspecified product | 0.004 | 0.0835 | 0.1904 |
Brugia malayi | Pre-SET motif family protein | 0.0033 | 0.0545 | 0.0228 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0133 | 0.0048 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0133 | 0.0133 |
Echinococcus granulosus | dna polymerase kappa | 0.004 | 0.0835 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2979 | 0.2979 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0065 | 0.1859 | 0.9521 |
Onchocerca volvulus | 0.0261 | 0.9799 | 1 | |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0229 | 0.8514 | 0.8514 |
Trichomonas vaginalis | set domain proteins, putative | 0.0261 | 0.9799 | 0.9781 |
Loa Loa (eye worm) | glutaminase | 0.0266 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0229 | 0.8514 | 0.8464 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0926 | 0.0926 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0025 | 0.0218 | 0.0204 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0218 | 0.0134 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0067 | 0.1925 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.004 | 0.0835 | 0.1904 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.004 | 0.0835 | 0.0756 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0033 | 0.0545 | 0.0463 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.107 | 0.0993 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.6582 | 0.6552 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.004 | 0.0835 | 0.1904 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.107 | 0.0771 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 36.7 % | Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed reduction in catalepsy at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 30 to 180 min | ChEMBL. | No reference |
TIME (functional) | = 118 s | Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 30 min | ChEMBL. | No reference |
TIME (functional) | = 128 s | Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 60 min | ChEMBL. | No reference |
TIME (functional) | = 156 s | Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 90 min | ChEMBL. | No reference |
TIME (functional) | = 173 s | Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 120 min | ChEMBL. | No reference |
TIME (functional) | = 201 s | Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 150 min | ChEMBL. | No reference |
TIME (functional) | = 224 s | Antiparkinsonian activity against haloperidol-induced catalepsy in Mus musculus Swiss albino (mouse) assessed as decrease in mean descent time at 100 mg/kg, ip administered 30 min prior to haloperidol injection measured after 180 min | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.