Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | cyclin A, putative | 0.0182 | 0.3669 | 0.8935 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0044 | 0.0412 | 0.1953 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0116 | 0.2109 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0082 | 0.1317 | 0.481 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0143 | 0.2747 | 0.4924 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.2449 | 0.2285 |
Onchocerca volvulus | 0.0135 | 0.256 | 0.6733 | |
Echinococcus granulosus | cyclins | 0.0116 | 0.2116 | 0.3668 |
Giardia lamblia | Cyclin A | 0.0116 | 0.2116 | 0.5425 |
Echinococcus granulosus | cyclins | 0.0116 | 0.2116 | 0.3668 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0182 | 0.3669 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0182 | 0.3669 | 0.8935 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0116 | 0.2109 | 1 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0116 | 0.2116 | 0.3668 |
Onchocerca volvulus | 0.0072 | 0.1082 | 0.2381 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0143 | 0.2747 | 0.4924 |
Leishmania major | cyclin | 0.0182 | 0.3669 | 1 |
Echinococcus multilocularis | cyclins | 0.0116 | 0.2116 | 0.3668 |
Trichomonas vaginalis | cyclins, putative | 0.0182 | 0.3669 | 0.8935 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0072 | 0.1082 | 0.0889 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0063 | 0.0869 | 0.4119 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0182 | 0.3669 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0116 | 0.2116 | 0.4847 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0062 | 0.0845 | 0.172 |
Trichomonas vaginalis | cyclin B, putative | 0.0182 | 0.3669 | 0.8935 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0116 | 0.2116 | 0.3668 |
Echinococcus multilocularis | cyclins | 0.0116 | 0.2116 | 0.3668 |
Entamoeba histolytica | cyclin, putative | 0.0182 | 0.3669 | 0.8935 |
Trichomonas vaginalis | cyclin H, putative | 0.0199 | 0.4074 | 1 |
Echinococcus granulosus | cyclins | 0.0116 | 0.2116 | 0.3668 |
Trypanosoma cruzi | cyclin, putative | 0.0182 | 0.3669 | 1 |
Schistosoma mansoni | g1/s-specific cyclin C | 0.0251 | 0.5296 | 1 |
Trichomonas vaginalis | cyclin B3, putative | 0.0116 | 0.2116 | 0.4847 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0065 | 0.0897 | 0.4254 |
Schistosoma mansoni | kinase | 0.0143 | 0.2747 | 0.4924 |
Loa Loa (eye worm) | cyclin C | 0.0251 | 0.5296 | 0.5193 |
Trichomonas vaginalis | cyclin D, putative | 0.0116 | 0.2116 | 0.4847 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0168 | 0.3331 | 0.6087 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0116 | 0.2116 | 0.4847 |
Trypanosoma cruzi | cyclin, putative | 0.0182 | 0.3669 | 1 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0182 | 0.3669 | 1 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0038 | 0.0274 | 0.0062 |
Echinococcus multilocularis | cyclins | 0.0116 | 0.2116 | 0.3668 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0078 | 0.1203 | 0.5702 |
Entamoeba histolytica | cyclin family protein | 0.0116 | 0.2116 | 0.4847 |
Plasmodium vivax | cyclin homologue, putative | 0.0038 | 0.0274 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0075 | 0.1147 | 0.5436 |
Echinococcus multilocularis | cyclins | 0.0116 | 0.2116 | 0.3668 |
Trichomonas vaginalis | cyclin B, putative | 0.0182 | 0.3669 | 0.8935 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0147 | 0.2844 | 0.2642 |
Mycobacterium ulcerans | thioesterase TesA | 0.0065 | 0.0897 | 0.2064 |
Trichomonas vaginalis | cyclins, putative | 0.0182 | 0.3669 | 0.8935 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0065 | 0.0897 | 0.2064 |
Echinococcus granulosus | cyclins | 0.0116 | 0.2116 | 0.3668 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0082 | 0.1317 | 0.481 |
Schistosoma mansoni | cyclin B | 0.0182 | 0.3669 | 0.6761 |
Echinococcus multilocularis | cyclin b3 | 0.0116 | 0.2116 | 0.3668 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0078 | 0.1203 | 0.4065 |
Echinococcus granulosus | cyclin b3 | 0.0116 | 0.2116 | 0.3668 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0116 | 0.2116 | 0.1894 |
Toxoplasma gondii | hypothetical protein | 0.0078 | 0.1212 | 0.8997 |
Trichomonas vaginalis | cyclins, putative | 0.0182 | 0.3669 | 0.8935 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0062 | 0.0845 | 0.172 |
Plasmodium vivax | hypothetical protein, conserved | 0.0038 | 0.0274 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0082 | 0.1317 | 0.481 |
Schistosoma mansoni | cyclin B3 | 0.0116 | 0.2116 | 0.3668 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0078 | 0.1203 | 0.4065 |
Echinococcus granulosus | oligomeric golgi complex subunit 3 | 0.0251 | 0.5296 | 1 |
Echinococcus granulosus | cyclin | 0.0251 | 0.5296 | 1 |
Echinococcus multilocularis | oligomeric golgi complex subunit 3 | 0.0251 | 0.5296 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0199 | 0.4074 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0182 | 0.3669 | 0.3491 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0274 | 0.0062 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0038 | 0.0274 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3669 | 0.3532 |
Giardia lamblia | Hypothetical protein | 0.0116 | 0.2116 | 0.5425 |
Plasmodium vivax | cyclin 4, putative | 0.0038 | 0.0274 | 0.5 |
Onchocerca volvulus | 0.0182 | 0.3669 | 1 | |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0062 | 0.0845 | 0.172 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0082 | 0.1317 | 0.6242 |
Mycobacterium ulcerans | thioesterase | 0.0065 | 0.0897 | 0.2064 |
Echinococcus multilocularis | cyclin B | 0.0182 | 0.3669 | 0.6761 |
Echinococcus multilocularis | cyclins | 0.0116 | 0.2116 | 0.3668 |
Trypanosoma cruzi | cyclin 6, putative | 0.0182 | 0.3669 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0116 | 0.2116 | 0.4847 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0397 | 0.0188 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0082 | 0.1317 | 0.6242 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0038 | 0.0274 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0923 | 0.0726 |
Plasmodium vivax | cyclin dependent kinase binding protein, putative | 0.0038 | 0.0274 | 0.5 |
Echinococcus multilocularis | cyclins | 0.0116 | 0.2116 | 0.3668 |
Trichomonas vaginalis | cyclins, putative | 0.0182 | 0.3669 | 0.8935 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0038 | 0.0274 | 0.0062 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0116 | 0.2109 | 1 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0182 | 0.3669 | 1 |
Echinococcus granulosus | cyclins | 0.0116 | 0.2116 | 0.3668 |
Loa Loa (eye worm) | CMGC/CDK/CDK9 protein kinase | 0.0143 | 0.2747 | 0.2589 |
Brugia malayi | cyclin-dependent kinase 9 | 0.0143 | 0.2747 | 0.2542 |
Mycobacterium ulcerans | polyketide synthase | 0.0078 | 0.1203 | 0.4065 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0078 | 0.1203 | 0.5702 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0078 | 0.1203 | 0.4065 |
Entamoeba histolytica | cyclin, putative | 0.0116 | 0.2116 | 0.4847 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0116 | 0.2116 | 0.1945 |
Echinococcus multilocularis | cyclin | 0.0251 | 0.5296 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0082 | 0.1317 | 0.481 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0056 | 0.0687 | 0.3255 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0078 | 0.1203 | 0.4065 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0143 | 0.2747 | 0.6507 |
Echinococcus multilocularis | cyclin B3 1 | 0.0116 | 0.2116 | 0.3668 |
Loa Loa (eye worm) | CYL-1 protein | 0.0038 | 0.0274 | 0.0062 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0078 | 0.1203 | 0.0955 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0072 | 0.1082 | 0.5131 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0082 | 0.1317 | 0.481 |
Trichomonas vaginalis | cyclins, putative | 0.0104 | 0.1827 | 0.4087 |
Loa Loa (eye worm) | fatty acid synthase | 0.0076 | 0.1178 | 0.0987 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0082 | 0.1317 | 0.6242 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0078 | 0.1203 | 0.4065 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0078 | 0.1203 | 0.4065 |
Echinococcus multilocularis | cyclins | 0.0116 | 0.2116 | 0.3668 |
Echinococcus granulosus | cyclin B | 0.0182 | 0.3669 | 0.6761 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0116 | 0.2109 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.3669 | 0.3532 |
Echinococcus granulosus | cyclin dependent kinase 9 | 0.0143 | 0.2747 | 0.4924 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0039 | 0.0296 | 0.0215 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0031 | 0.0111 | 0.0527 |
Trichomonas vaginalis | cyclin B, putative | 0.0182 | 0.3669 | 0.8935 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.005 | 0.0559 | 0.2734 |
Schistosoma mansoni | cyclins | 0.0116 | 0.2116 | 0.3668 |
Entamoeba histolytica | cyclin family protein | 0.0116 | 0.2116 | 0.4847 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.045 | 1 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0078 | 0.1203 | 0.5702 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0038 | 0.0274 | 0.0062 |
Mycobacterium ulcerans | polyketide synthase | 0.0082 | 0.1317 | 0.481 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0075 | 0.1147 | 0.5436 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0274 | 0.0062 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0182 | 0.3669 | 0.3491 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.014 | 0.2674 | 0.7068 |
Loa Loa (eye worm) | cyclin fold protein 1 variant b | 0.0038 | 0.0274 | 0.0062 |
Plasmodium falciparum | cyclin | 0.0116 | 0.2116 | 1 |
Echinococcus granulosus | cyclin B3 1 | 0.0116 | 0.2116 | 0.3668 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0082 | 0.1317 | 1 |
Echinococcus multilocularis | cyclin dependent kinase 9 | 0.0168 | 0.3331 | 0.6087 |
Trichomonas vaginalis | cyclin D, putative | 0.0116 | 0.2116 | 0.4847 |
Brugia malayi | AMP-binding enzyme family protein | 0.0072 | 0.1082 | 0.0831 |
Brugia malayi | Cyclin C | 0.0251 | 0.5296 | 0.5163 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0055 | 0.0675 | 0.3843 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 76.74 % | Inhibition of alpha amylase (unknown origin) at 1 mg/ml after 10 min relative to control | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.