Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | glutaminase | 0.027 | 0.1418 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1744 | 0.1744 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0039 | 0.0022 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0289 | 0.1535 | 0.1535 |
Schistosoma mansoni | coup transcription factor | 0.0613 | 0.3494 | 0.4274 |
Onchocerca volvulus | 0.0098 | 0.0378 | 0.1083 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0613 | 0.3494 | 0.4274 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0613 | 0.3494 | 0.4274 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.01 | 0.01 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0613 | 0.3494 | 0.4274 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0613 | 0.3494 | 0.4274 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0613 | 0.3494 | 0.3494 |
Loa Loa (eye worm) | glutaminase 2 | 0.027 | 0.1418 | 0.1418 |
Brugia malayi | ecdysone receptor | 0.0289 | 0.1535 | 0.1535 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0613 | 0.3494 | 0.4274 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0289 | 0.1535 | 0.1877 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0039 | 0.0022 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0613 | 0.3494 | 0.3494 |
Echinococcus granulosus | FTZ F1 alpha | 0.0613 | 0.3494 | 0.4274 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | hypothetical protein | 0.0481 | 0.2694 | 0.2694 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1744 | 0.1744 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0074 | 0.0091 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0526 | 0.1505 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0324 | 0.1744 | 0.2134 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0022 | 0.0027 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0039 | 0.0022 | 0.0022 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0613 | 0.3494 | 0.4274 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0613 | 0.3494 | 0.3494 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.1365 | 0.804 | 0.9835 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1388 | 0.8175 | 0.8575 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0039 | 0.0022 | 0.0023 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0613 | 0.3494 | 0.3494 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Schistosoma mansoni | nuclear hormone receptor | 0.0289 | 0.1535 | 0.1877 |
Brugia malayi | nuclear receptor RXR | 0.0289 | 0.1535 | 0.1535 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0039 | 0.0022 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0613 | 0.3494 | 0.3494 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1744 | 0.1744 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0613 | 0.3494 | 0.3494 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0039 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.01 | 0.01 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0613 | 0.3494 | 0.3665 |
Brugia malayi | hypothetical protein | 0.0123 | 0.0526 | 0.0526 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0324 | 0.1744 | 0.2134 |
Schistosoma mansoni | hypothetical protein | 0.0098 | 0.0378 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0289 | 0.1535 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0526 | 0.0526 |
Schistosoma mansoni | nuclear receptor | 0.0289 | 0.1535 | 0.1877 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0613 | 0.3494 | 0.3494 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0613 | 0.3494 | 0.3494 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0074 | 0.0078 |
Schistosoma mansoni | glutaminase | 0.027 | 0.1418 | 0.1735 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0613 | 0.3494 | 0.3494 |
Schistosoma mansoni | ap endonuclease | 0.0039 | 0.0022 | 0.0027 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0613 | 0.3494 | 0.3665 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0039 | 0.0022 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0324 | 0.1744 | 0.2134 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0613 | 0.3494 | 0.3665 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0613 | 0.3494 | 0.3665 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0613 | 0.3494 | 0.3494 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0481 | 0.2694 | 0.3295 |
Loa Loa (eye worm) | DR-78 | 0.0289 | 0.1535 | 0.1535 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0613 | 0.3494 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0039 | 0.0022 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0613 | 0.3494 | 0.4274 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0613 | 0.3494 | 0.3494 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0613 | 0.3494 | 0.4274 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0324 | 0.1744 | 0.183 |
Brugia malayi | nuclear receptor RXR | 0.0324 | 0.1744 | 0.1744 |
Schistosoma mansoni | thyroid hormone receptor | 0.0613 | 0.3494 | 0.4274 |
Brugia malayi | glutaminase DH11.1 | 0.027 | 0.1418 | 0.1418 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1388 | 0.8175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Brugia malayi | conserved hypotetical protein | 0.0289 | 0.1535 | 0.1535 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0613 | 0.3494 | 0.4274 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0613 | 0.3494 | 0.4274 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0289 | 0.1535 | 0.1535 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0613 | 0.3494 | 0.3665 |
Schistosoma mansoni | zinc finger protein | 0.0289 | 0.1535 | 0.1877 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0613 | 0.3494 | 0.3494 |
Onchocerca volvulus | Huntingtin homolog | 0.0123 | 0.0526 | 0.1505 |
Onchocerca volvulus | 0.0613 | 0.3494 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0613 | 0.3494 | 0.4274 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0289 | 0.1535 | 0.161 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1388 | 0.8175 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1744 | 0.1744 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0324 | 0.1744 | 0.1744 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0289 | 0.1535 | 0.4392 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0289 | 0.1535 | 0.4392 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0074 | 0.0091 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0289 | 0.1535 | 0.161 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0289 | 0.1535 | 0.1535 |
Trichomonas vaginalis | glutaminase, putative | 0.027 | 0.1418 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0289 | 0.1535 | 0.1535 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0289 | 0.1535 | 0.1877 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0613 | 0.3494 | 0.4274 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1689 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0613 | 0.3494 | 0.3665 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0022 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0289 | 0.1535 | 0.1877 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0324 | 0.1744 | 0.1744 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0613 | 0.3494 | 0.3494 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.0074 | 0.0091 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0098 | 0.0378 | 0.0378 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0613 | 0.3494 | 0.3494 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0613 | 0.3494 | 0.3665 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0289 | 0.1535 | 0.1877 |
Brugia malayi | ecdysteroid receptor | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | hypothetical protein | 0.0324 | 0.1744 | 0.1744 |
Onchocerca volvulus | 0.0289 | 0.1535 | 0.4392 | |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0 | 0.0001 |
Brugia malayi | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.1744 | 0.1744 |
Schistosoma mansoni | thyroid hormone receptor | 0.0613 | 0.3494 | 0.4274 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0074 | 0.0078 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0289 | 0.1535 | 0.1535 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.01 | 0.01 |
Schistosoma mansoni | survival motor neuron protein | 0.0098 | 0.0378 | 0.0463 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0289 | 0.1535 | 0.161 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Schistosoma mansoni | nuclear hormone receptor | 0.0289 | 0.1535 | 0.1877 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0022 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0074 | 0.0074 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0039 | 0.0022 | 1 |
Loa Loa (eye worm) | glutaminase | 0.027 | 0.1418 | 0.1418 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0613 | 0.3494 | 0.4274 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0039 | 0.0022 | 0.0189 |
Schistosoma mansoni | nuclear hormone receptor | 0.0613 | 0.3494 | 0.4274 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0289 | 0.1535 | 0.1877 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0289 | 0.1535 | 0.1877 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.0526 | 0.0526 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0613 | 0.3494 | 0.3494 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0039 | 0.0022 | 0.0155 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0613 | 0.3494 | 0.4274 |
Brugia malayi | nuclear receptor NHR-88 | 0.0289 | 0.1535 | 0.1535 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0613 | 0.3494 | 0.4274 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.01 | 0.01 |
Brugia malayi | tailless protein | 0.0289 | 0.1535 | 0.1535 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0613 | 0.3494 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0039 | 0.0022 | 1 |
Brugia malayi | hypothetical protein | 0.0324 | 0.1744 | 0.1744 |
Schistosoma mansoni | nuclear receptor | 0.0289 | 0.1535 | 0.1877 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0289 | 0.1535 | 0.1535 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0227 | 0.1159 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0289 | 0.1535 | 0.161 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0613 | 0.3494 | 0.3494 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0039 | 0.0022 | 0.0027 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0289 | 0.1535 | 0.161 |
Loa Loa (eye worm) | hypothetical protein | 0.0613 | 0.3494 | 0.3494 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0289 | 0.1535 | 0.161 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0022 | 0.0155 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0613 | 0.3494 | 0.3494 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0613 | 0.3494 | 0.4274 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0613 | 0.3494 | 0.3494 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0613 | 0.3494 | 0.3665 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0613 | 0.3494 | 0.3665 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0481 | 0.2694 | 0.2826 |
Brugia malayi | nuclear hormone receptor | 0.0289 | 0.1535 | 0.1535 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0613 | 0.3494 | 0.4274 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0074 | 0.0091 |
Loa Loa (eye worm) | hypothetical protein | 0.0481 | 0.2694 | 0.2694 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.1535 | 0.1535 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0289 | 0.1535 | 0.1877 |
Brugia malayi | nuclear hormone receptor | 0.0613 | 0.3494 | 0.3494 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0613 | 0.3494 | 0.3494 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0039 | 0.0022 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.1612 | 0.9533 | 1 |
Onchocerca volvulus | 0.0289 | 0.1535 | 0.4392 | |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0039 | 0.0022 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.0074 | 0.0074 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0074 | 0.0091 |
Brugia malayi | nuclear receptor NHR-67 | 0.0289 | 0.1535 | 0.1535 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0039 | 0.0022 | 0.0155 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0613 | 0.3494 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0324 | 0.1744 | 0.1744 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.038 uM | Agonist activity (EC50) was assessed by measuring cAMP levels in CHO cells expressing cloned human Beta-3 adrenergic receptor | ChEMBL. | 15149682 |
IA (functional) | = 7 | Intrinsic activity (IA) human Beta-2 adrenergic receptor (at 30uM, represent by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
IA (functional) | = 10 | Intrinsic activity (IA) at human Beta-1 adrenergic receptor (at 30uM, represented by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
IA (functional) | = 98 | Intrinsic activity (IA) at human Beta-3 adrenergic receptor (represented by the percentage of the maximal response attained by isoproterenol) | ChEMBL. | 15149682 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.