TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 341.788 | Formula: C19H16ClNO3
H donors: 1 H acceptors: 3 LogP: 4.07 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CN1C/C(=C\c2ccc(cc2)C)/C(=O)c2c1c(Cl)ccc2
InChi: 1S/C19H16ClNO3/c1-12-5-7-13(8-6-12)9-14-10-21(11-17(22)23)18-15(19(14)24)3-2-4-16(18)20/h2-9H,10-11H2,1H3,(H,22,23)/b14-9+
InChiKey: MECNPCKTUDOWPN-NTEUORMPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0247	0.3375	0.3279
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0247	0.3375	0.3279
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0026	0.0142	0.003
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0247	0.3375	1
Onchocerca volvulus		0.0247	0.3375	1
Schistosoma mansoni	neuropeptide receptor	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	larval opioid receptor	0.0247	0.3375	1
Echinococcus multilocularis	fmrfamide receptor	0.0247	0.3375	0.3279
Echinococcus granulosus	neuropeptide receptor A26	0.0701	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Schistosoma mansoni	amine GPCR	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	G protein-coupled receptor	0.0247	0.3375	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	oxidoreductase	0.0026	0.0142	0.0047
Echinococcus granulosus	7TM GPCR rhodopsin	0.0247	0.3375	0.3279
Echinococcus granulosus	tm gpcr rhodopsin	0.0247	0.3375	0.3279
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0247	0.3375	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0247	0.3375	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0247	0.3375	1
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Brugia malayi	putative neuropeptide receptor	0.0247	0.3375	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1466	0.4122
Echinococcus granulosus	fmrfamide receptor	0.0247	0.3375	0.3279
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0247	0.3375	0.3279
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0247	0.3375	1
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0026	0.0142	0.003
Brugia malayi	RE15519p	0.0247	0.3375	1
Brugia malayi	ORL1-like opioid receptor	0.0247	0.3375	1
Schistosoma mansoni	amine GPCR	0.0247	0.3375	1
Echinococcus multilocularis	g protein coupled receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	neuropeptide s receptor	0.0701	1	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0247	0.3375	1
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Onchocerca volvulus		0.0247	0.3375	1
Leishmania major	pteridine reductase 1	0.0026	0.0142	1
Echinococcus multilocularis	neuropeptide receptor	0.0247	0.3375	0.3279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Echinococcus granulosus	neuropeptides capa receptor	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0247	0.3375	0.3279
Echinococcus multilocularis	dro:myosuppressin receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0247	0.3375	0.3279
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0026	0.0142	1
Trypanosoma brucei	oxidoreductase-like protein	0.0026	0.0142	1
Echinococcus multilocularis	somatostatin receptor	0.0247	0.3375	0.3279
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0026	0.0142	0.0421
Echinococcus multilocularis	serotonin receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	neuropeptides capa receptor	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Schistosoma mansoni	adenoreceptor	0.0247	0.3375	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0247	0.3375	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0247	0.3375	1
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0378	0.5283	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0247	0.3375	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0247	0.3375	1
Brugia malayi	Dopamine receptor protein 1	0.0247	0.3375	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Brugia malayi	Melatonin receptor type 1A	0.0247	0.3375	1
Echinococcus granulosus	somatostatin receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	G-protein coupled receptor	0.0247	0.3375	1
Brugia malayi	neuropeptide F receptor	0.0247	0.3375	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0247	0.3375	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0247	0.3375	0.3279
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0378	0.5283	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus multilocularis	g protein coupled receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	amine GPCR	0.0247	0.3375	1
Schistosoma mansoni	neuropeptide receptor	0.0247	0.3375	1
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	AKH receptor	0.0247	0.3375	1
Schistosoma mansoni	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Schistosoma mansoni	biogenic amine receptor	0.0247	0.3375	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0026	0.0142	0.0047
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0247	0.3375	0.3279
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0026	0.0142	0.003
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0247	0.3375	1
Schistosoma mansoni	neuropeptide receptor	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0247	0.3375	1
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus multilocularis	orexin receptor type 2	0.0247	0.3375	0.3279
Schistosoma mansoni	amine GPCR	0.0247	0.3375	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0247	0.3375	0.3279
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0378	0.5283	1
Echinococcus granulosus	g protein coupled receptor	0.0247	0.3375	0.3279
Brugia malayi	Serotonin receptor	0.0247	0.3375	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0247	0.3375	0.3279
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0378	0.5283	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0247	0.3375	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	TYRA-2 protein	0.0247	0.3375	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0026	0.0142	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0247	0.3375	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0247	0.3375	0.3279
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0247	0.3375	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0247	0.3375	0.3279
Echinococcus granulosus	neuropeptide Y receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	g protein coupled receptor	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	histamine h1 receptor	0.0247	0.3375	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0247	0.3375	1
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0026	0.0142	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0247	0.3375	0.3279
Schistosoma mansoni	biogenic amine receptor	0.0247	0.3375	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0378	0.5283	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	g protein coupled receptor	0.0247	0.3375	0.3279
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0026	0.0142	1
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0026	0.0142	0.0421
Schistosoma mansoni	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0247	0.3375	1
Echinococcus granulosus	G protein coupled receptor 139	0.0247	0.3375	0.3279
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0247	0.3375	0.3279
Echinococcus multilocularis	serotonin receptor	0.0247	0.3375	0.3279
Echinococcus granulosus	neuropeptide Y receptor	0.0247	0.3375	0.3279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	fmrfamide receptor	0.0247	0.3375	0.3279
Brugia malayi	neuropeptide F receptor	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0026	0.0142	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0247	0.3375	0.3279
Brugia malayi	GnHR receptor homolog	0.0247	0.3375	1
Echinococcus granulosus	orexin receptor type 2	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	g protein coupled receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0247	0.3375	0.3279
Schistosoma mansoni	biogenic amine receptor	0.0247	0.3375	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0026	0.0142	0.003
Echinococcus granulosus	tm gpcr rhodopsin	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Trypanosoma brucei	pteridine reductase 1	0.0026	0.0142	1
Schistosoma mansoni	myosin xvIII	0.0247	0.3375	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0247	0.3375	1
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0026	0.0142	0.003
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	opsin-like receptor	0.0247	0.3375	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0247	0.3375	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus granulosus	sex peptide receptor	0.0247	0.3375	0.3279
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0247	0.3375	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0378	0.5283	1
Schistosoma mansoni	neuropeptide receptor	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Trichomonas vaginalis	hypothetical protein	0.0378	0.5283	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0247	0.3375	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1466	0.4122
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	MH2 domain containing protein	0.0116	0.1466	0.4343
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0247	0.3375	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Schistosoma mansoni	opsin-like receptor	0.0247	0.3375	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0247	0.3375	1
Brugia malayi	follicle stimulating hormone receptor	0.0247	0.3375	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0247	0.3375	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0247	0.3375	0.3279
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Brugia malayi	Dopamine receptor	0.0247	0.3375	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Echinococcus granulosus	7tm_1 domain containing protein	0.0247	0.3375	0.3279
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0247	0.3375	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0247	0.3375	0.3279
Schistosoma mansoni	opsin-like receptor	0.0247	0.3375	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0142	0.0047
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0247	0.3375	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0247	0.3375	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0247	0.3375	0.3279
Echinococcus granulosus	hypothetical protein	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus granulosus	g-protein coupled receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus granulosus	neuropeptide receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Echinococcus multilocularis	sex peptide receptor	0.0247	0.3375	0.3279
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0026	0.0142	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0247	0.3375	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0247	0.3375	0.3279
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0247	0.3375	1
Brugia malayi	Serotonin receptor	0.0247	0.3375	1
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0378	0.5283	1
Onchocerca volvulus		0.0247	0.3375	1
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0026	0.0142	0.5
Brugia malayi	G-protein coupled receptor	0.0247	0.3375	1
Echinococcus multilocularis	neuropeptide receptor	0.0247	0.3375	0.3279
Brugia malayi	hypothetical protein	0.0025	0.0127	0.0376
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0247	0.3375	0.3279
Schistosoma mansoni	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	neuropeptide receptor	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0247	0.3375	1
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0378	0.5283	1
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0026	0.0142	1
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0026	0.0142	0.0047
Echinococcus multilocularis	G protein coupled receptor 139	0.0247	0.3375	0.3279
Brugia malayi	Dopamine receptor protein 2	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Onchocerca volvulus		0.0247	0.3375	1
Echinococcus multilocularis	allatostatin A receptor	0.0247	0.3375	0.3279
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0247	0.3375	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0247	0.3375	0.3279
Echinococcus granulosus	rhodopsin orphan GPCR	0.0247	0.3375	0.3279
Echinococcus granulosus	allatostatin A receptor	0.0247	0.3375	0.3279
Schistosoma mansoni	amine GPCR	0.0247	0.3375	1
Leishmania major	oxidoreductase-like protein	0.0026	0.0142	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0247	0.3375	1
Brugia malayi	hypothetical protein	0.0247	0.3375	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0247	0.3375	0.3279
Brugia malayi	G-protein coupled receptor	0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0247	0.3375	0.3279
Onchocerca volvulus		0.0247	0.3375	1
Loa Loa (eye worm)	hypothetical protein	0.0247	0.3375	1
Echinococcus granulosus	serotonin receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	g-protein coupled receptor	0.0247	0.3375	0.3279
Brugia malayi	sulfakinin receptor protein	0.0247	0.3375	1
Echinococcus granulosus	neuropeptides capa receptor	0.0247	0.3375	0.3279
Echinococcus multilocularis	neuropeptide receptor A26	0.0701	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0247	0.3375	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 67.59 %	Inhibition of glutathione S-transferase P1-1 in Homo sapiens (human) HL60 cell lysate using CDNB and GSH as substrate at 20 uM by spectrophotometric analysis	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2235817

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1815759