Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | biogenic amine receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.005 | 0.4144 | 0.5551 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.3922 | 0.3888 | |
Echinococcus granulosus | neuropeptide s receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0029 | 0.1609 | 0.2155 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0054 | 0.473 | 0.6337 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0051 | 0.4337 | 0.581 |
Echinococcus multilocularis | somatostatin receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | allatostatin A receptor | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1557 | 0.1375 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0048 | 0.3922 | 0.5254 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0041 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0037 | 0.2556 | 0.3424 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0051 | 0.4337 | 0.4084 |
Echinococcus granulosus | fmrfamide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.002 | 0.0428 | 0.5 |
Onchocerca volvulus | 0.0089 | 0.9021 | 0.9563 | |
Echinococcus granulosus | g-protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0036 | 0.2515 | 0.3708 |
Echinococcus granulosus | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | histamine h1 receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | sex peptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0034 | 0.2195 | 0.2941 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0043 | 0.3283 | 0.4398 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0092 | 0.9413 | 1 |
Echinococcus granulosus | orexin receptor type 2 | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0034 | 0.2195 | 0.2941 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0048 | 0.3922 | 0.4256 |
Echinococcus granulosus | somatostatin receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0043 | 0.3283 | 0.4398 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | allatostatin A receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | sex peptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0033 | 0.2116 | 0.2574 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.002 | 0.0428 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0054 | 0.473 | 1 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0041 | 0.3102 | 0.4155 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0042 | 0.3185 | 0.4267 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4337 | 0.581 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0018 | 0.0188 | 0.0251 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0034 | 0.2195 | 0.2941 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0051 | 0.4337 | 0.581 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | fatty acid synthase | 0.0051 | 0.4253 | 0.466 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.002 | 0.0428 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.3922 | 0.365 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0054 | 0.473 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0051 | 0.4337 | 0.581 |
Echinococcus multilocularis | orexin receptor type 2 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.8637 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0054 | 0.473 | 0.6337 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | myosin xvIII | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0021 | 0.0571 | 0.0765 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0043 | 0.3283 | 0.4398 |
Echinococcus granulosus | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | acyl carrier protein | 0.0024 | 0.0922 | 0.0601 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0041 | 0.3102 | 0.4155 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0077 | 0.7465 | 1 |
Echinococcus multilocularis | neuropeptide s receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.005 | 0.4144 | 0.5551 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0051 | 0.4337 | 0.581 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | thioesterase | 0.0043 | 0.3283 | 0.4398 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g-protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | serotonin receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0077 | 0.7465 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0077 | 0.7465 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0077 | 0.7465 | 1 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.473 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (functional) | = 650 ppm | Nematicidal activity against Caenorhabditis elegans assessed as immobility | ChEMBL. | 19571412 |
MBC (functional) | = 6.25 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 37 degC for 48 hr | ChEMBL. | 19571412 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.