Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.002 | 0.0428 | 0.5 |
Brugia malayi | AMP-binding enzyme family protein | 0.0048 | 0.3922 | 0.365 |
Echinococcus multilocularis | G protein coupled 5 hydroxytryptamine receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0051 | 0.4337 | 0.581 |
Echinococcus multilocularis | orexin receptor type 2 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.8637 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | histamine-responsive GPCR (AAF21638) | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0054 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | myosin xvIII | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0054 | 0.473 | 0.6337 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0021 | 0.0571 | 0.0765 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0043 | 0.3283 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0041 | 0.3102 | 0.4155 |
Loa Loa (eye worm) | acyl carrier protein | 0.0024 | 0.0922 | 0.0601 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0077 | 0.7465 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0033 | 0.2116 | 0.2574 |
Echinococcus granulosus | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0054 | 0.473 | 1 |
Echinococcus granulosus | G protein coupled 5 hydroxytryptamine receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | G-protein coupled receptor, putative | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0041 | 0.3102 | 0.4155 |
Schistosoma mansoni | neuropeptide f receptor 76f | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0042 | 0.3185 | 0.4267 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0018 | 0.0188 | 0.0251 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0034 | 0.2195 | 0.2941 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | fatty acid synthase | 0.0051 | 0.4253 | 0.466 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0051 | 0.4337 | 0.581 |
Schistosoma mansoni | alpha-1 adrenergic receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | thyrotropin releasing hormone receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | adenoreceptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0054 | 0.473 | 0.6337 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g-protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | serotonin receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | pyroglutamylated rfamide peptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0054 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0077 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0077 | 0.7465 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0077 | 0.7465 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Echinococcus multilocularis | growth hormone secretagogue receptor type 1 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0051 | 0.4337 | 0.581 |
Echinococcus granulosus | pyroglutamylated rfamide peptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.005 | 0.4144 | 0.5551 |
Echinococcus granulosus | alpha 1A adrenergic receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Mycobacterium ulcerans | thioesterase | 0.0043 | 0.3283 | 0.4398 |
Schistosoma mansoni | peptide (allatostatin/somatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0051 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0037 | 0.2556 | 0.3424 |
Echinococcus multilocularis | biogenic amine (5HT) receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0041 | 0.3102 | 0.4155 |
Echinococcus multilocularis | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.002 | 0.0428 | 0.5 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0051 | 0.4337 | 0.4084 |
Echinococcus granulosus | fmrfamide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | 7TM GPCR, rhodopsin | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0036 | 0.2515 | 0.3708 |
Echinococcus granulosus | g-protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Onchocerca volvulus | 0.0089 | 0.9021 | 0.9563 | |
Echinococcus multilocularis | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | muscarinic acetylcholine (GAR) receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | histamine h1 receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | sex peptide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Schistosoma mansoni | biogenic amine receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/somatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Onchocerca volvulus | 0.0048 | 0.3922 | 0.3888 | |
Echinococcus granulosus | neuropeptide s receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.005 | 0.4144 | 0.5551 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0029 | 0.1609 | 0.2155 |
Echinococcus granulosus | neuropeptide FF receptor 2 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | growth hormone secretagogue receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | 7tm_1 domain containing protein | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | amine GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide FF receptor 2 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | peptide allatostatin:somatostatin | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0054 | 0.473 | 0.6337 |
Echinococcus granulosus | 7TM GPCR rhodopsin | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | somatostatin receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0051 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0048 | 0.3922 | 0.5254 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1557 | 0.1375 |
Echinococcus multilocularis | allatostatin A receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0034 | 0.2195 | 0.2941 |
Echinococcus multilocularis | dro:myosuppressin receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide Y receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | opsin-like receptor | 0.002 | 0.0428 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0048 | 0.3922 | 0.4256 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | fmrfamide receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | somatostatin receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | dro:myosuppressin receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | allatostatin A receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | sex peptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | peptide (FMRFamide/neurokinin-3)-like receptor | 0.002 | 0.0428 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0043 | 0.3283 | 0.4398 |
Echinococcus granulosus | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | growth hormone secretagogue receptor type 1 | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein linked acetylcholine receptor gar 2a | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | alpha 1A adrenergic receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | biogenic amine receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | peptide (allatostatin:somatostatin) | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | neuropeptides capa receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | ancient conserved domain protein 2 (cyclin m2) | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0043 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0034 | 0.2195 | 0.2941 |
Schistosoma mansoni | neuropeptide F-like receptor | 0.002 | 0.0428 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0092 | 0.9413 | 1 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Schistosoma mansoni | rhodopsin-like orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | g protein coupled receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus multilocularis | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.0054 | 0.473 | 0.6337 |
Schistosoma mansoni | biogenic amine (dopamine) receptor | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | rhodopsin orphan GPCR | 0.002 | 0.0428 | 0.5 |
Echinococcus granulosus | orexin receptor type 2 | 0.002 | 0.0428 | 0.5 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0051 | 0.4337 | 0.581 |
Echinococcus granulosus | G protein coupled receptor 139 | 0.002 | 0.0428 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
LD50 (functional) | = 380 ppm | Nematicidal activity against Caenorhabditis elegans assessed as immobility | ChEMBL. | 19571412 |
MBC (functional) | = 12.5 ug ml-1 | Antifungal activity against Candida albicans ATCC 10231 assessed as growth inhibition at 37 degC for 48 hr | ChEMBL. | 19571412 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.