Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Cavia porcellus | Voltage-dependent L-type calcium channel subunit alpha-1C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | 60S acidic ribosomal protein P2 homolog | Voltage-dependent L-type calcium channel subunit alpha-1C | 169 aa | 144 aa | 24.3 % |
Schistosoma mansoni | cd63 antigen-like | Voltage-dependent L-type calcium channel subunit alpha-1C | 169 aa | 181 aa | 22.1 % |
Echinococcus multilocularis | sodium channel protein | Voltage-dependent L-type calcium channel subunit alpha-1C | 169 aa | 145 aa | 25.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0493 | 0.307 | 0.307 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0564 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0493 | 0.307 | 0.307 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0564 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0324 |
Trypanosoma brucei | unspecified product | 0.0324 | 0.161 | 0.161 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0938 | 0.6907 | 0.5 |
Trichomonas vaginalis | cyclin A, putative | 0.0138 | 0 | 0.5 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0176 | 0.0324 | 0.0324 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0802 | 0.5736 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase beta chain | 0.0176 | 0.0324 | 0.0324 |
Loa Loa (eye worm) | hypothetical protein | 0.0345 | 0.1791 | 0.1864 |
Echinococcus multilocularis | G1:S specific cyclin D1 | 0.0365 | 0.1961 | 0.1961 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0493 | 0.307 | 0.307 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.1961 | 0.2041 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0938 | 0.6907 | 0.5 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0493 | 0.307 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.1296 | 1 | 1 |
Chlamydia trachomatis | biotin carboxylase | 0.0448 | 0.2678 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0365 | 0.1961 | 0.2041 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.1296 | 1 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.125 | 0.9608 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.1296 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.1296 | 1 | 1 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0493 | 0.307 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0493 | 0.307 | 1 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0493 | 0.307 | 0.307 |
Schistosoma mansoni | pyruvate carboxylase | 0.0493 | 0.307 | 0.307 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0493 | 0.307 | 0.5352 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0221 | 0.0716 | 1 |
Onchocerca volvulus | 0.0138 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.125 | 0.9608 | 1 |
Echinococcus granulosus | G1:S specific cyclin D1 | 0.0365 | 0.1961 | 0.1961 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0493 | 0.307 | 0.307 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0493 | 0.307 | 0.5352 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.1296 | 1 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0176 | 0.0324 | 0.0324 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0493 | 0.307 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0493 | 0.307 | 0.307 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0493 | 0.307 | 1 |
Schistosoma mansoni | cyclin d | 0.0365 | 0.1961 | 0.1961 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase beta chain | 0.0176 | 0.0324 | 0.0324 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0493 | 0.307 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0493 | 0.307 | 0.307 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0176 | 0.0324 | 0.0564 |
Leishmania major | carboxylase, putative | 0.0493 | 0.307 | 0.307 |
Toxoplasma gondii | pyruvate carboxylase | 0.0493 | 0.307 | 0.2839 |
Trichomonas vaginalis | cyclins, putative | 0.0138 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0493 | 0.307 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.1296 | 1 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0493 | 0.307 | 1 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0176 | 0.0324 | 0.0324 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0221 | 0.0716 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0138 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.04 | Inhibition of L-type calcium channel in Cavia porcellus (guinea pig) ileal SMC assessed as inhibition of 80 mM KCl-induced current | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.