Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.432 | 0.9786 | 0.9786 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.432 | 0.9786 | 0.9786 |
Schistosoma mansoni | DNA topoisomerase type I | 0.1245 | 0.0903 | 0.0903 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.2594 | 0.4799 | 0.5 |
Plasmodium vivax | topoisomerase I, putative | 0.1245 | 0.0903 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.1875 | 0.2724 | 0.2724 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.4395 | 1 | 1 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.2594 | 0.4799 | 0.5 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2519 | 0.4585 | 0.4047 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.4395 | 1 | 1 |
Onchocerca volvulus | 0.4395 | 1 | 0.5 | |
Plasmodium falciparum | topoisomerase I | 0.1245 | 0.0903 | 0.5 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.1245 | 0.0903 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2594 | 0.4799 | 0.5 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.432 | 0.9786 | 0.9786 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1875 | 0.2724 | 0.2724 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1875 | 0.2724 | 0.2724 |
Mycobacterium ulcerans | hypothetical protein | 0.2594 | 0.4799 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.2594 | 0.4799 | 0.5 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.432 | 0.9786 | 0.9786 |
Loa Loa (eye worm) | hypothetical protein | 0.432 | 0.9786 | 0.9764 |
Brugia malayi | DNA topoisomerase I | 0.1245 | 0.0903 | 0.5 |
Schistosoma mansoni | 6-phosphofructokinase | 0.4395 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4395 | 1 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.1875 | 0.2724 | 0.2724 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.