TDR Targets

Basic information

Technical information

TDR Targets ID: 1816981
Name: (1R,5S)-3-[bis(4-fluorophenyl)methoxy]-8-[4-( 4-isothiocyanatophenyl)butyl]-8-azabicyclo[3. 2.1]octane
MW: 518.66 | Formula: C31H32F2N2OS
H donors: 0 H acceptors: 0 LogP: 8.75 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: S=C=Nc1ccc(cc1)CCCCN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccc(cc1)F)c1ccc(cc1)F
InChi: 1S/C31H32F2N2OS/c32-25-10-6-23(7-11-25)31(24-8-12-26(33)13-9-24)36-30-19-28-16-17-29(20-30)35(28)18-2-1-3-22-4-14-27(15-5-22)34-21-37/h4-15,28-31H,1-3,16-20H2/t28-,29+,30+
InChiKey: NDQHYTPBWHOLRM-BKHFGAQXSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Dopamine transporter	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	sodium/chloride dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma mansoni	norepinephrine/norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	solute carrier family 6 member 4	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Onchocerca volvulus		Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	norepinephrine transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus granulosus	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	IPR000175,Sodium:neurotransmitter symporter,domain-containing	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent noradrenaline transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Treponema pallidum	sodium- and chloride- dependent transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128364	All targets in OG5_128364
Echinococcus multilocularis	serotonin transporter	Get druggable targets OG5_128364	All targets in OG5_128364
Loa Loa (eye worm)	serotonin transporter b	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Schistosoma japonicum	Sodium-dependent dopamine transporter, putative	Get druggable targets OG5_128364	All targets in OG5_128364
Brugia malayi	Sodium:neurotransmitter symporter family protein	Get druggable targets OG5_128364	All targets in OG5_128364

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	sodium and chloride dependent glycine	Dopamine transporter	619 aa	599 aa	41.9 %
Neospora caninum	sodium-dependent transporter, putative	Dopamine transporter	619 aa	498 aa	32.3 %
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	588 aa	40.3 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	32.9 %
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	Dopamine transporter	619 aa	604 aa	37.9 %
Brugia malayi	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	578 aa	33.4 %
Schistosoma mansoni	sodium/chloride dependent transporter	Dopamine transporter	619 aa	558 aa	41.8 %
Onchocerca volvulus	Transmembrane protein 120 homolog	Dopamine transporter	619 aa	578 aa	32.9 %
Schistosoma japonicum	ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative	Dopamine transporter	619 aa	551 aa	39.9 %
Plasmodium vivax	hypothetical protein, conserved	Dopamine transporter	619 aa	657 aa	20.1 %
Onchocerca volvulus	High affinity copper uptake protein 1 homolog	Dopamine transporter	619 aa	599 aa	44.2 %
Echinococcus granulosus	sodium and chloride dependent glycine	Dopamine transporter	619 aa	594 aa	41.4 %
Drosophila melanogaster	CG1698 gene product from transcript CG1698-RA	Dopamine transporter	619 aa	522 aa	36.0 %
Schistosoma japonicum	ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative	Dopamine transporter	619 aa	509 aa	40.1 %
Drosophila melanogaster	CG13796 gene product from transcript CG13796-RD	Dopamine transporter	619 aa	557 aa	23.9 %
Onchocerca volvulus		Dopamine transporter	619 aa	612 aa	23.5 %
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	Dopamine transporter	619 aa	636 aa	31.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0071	0.373	0.4822
Schistosoma mansoni	neuropeptide receptor	0.0071	0.373	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	opsin-like receptor	0.0071	0.373	0.4822
Onchocerca volvulus		0.0071	0.373	0.001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.373	0.1611
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus granulosus	orexin receptor type 2	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0071	0.373	0.1611
Brugia malayi	metabotropic glutamate receptor type 2	0.0048	0.1462	0.1462
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0071	0.373	0.1611
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.373	0.1611
Schistosoma mansoni	hypothetical protein	0.0071	0.373	0.4822
Loa Loa (eye worm)	TTK protein kinase	0.0071	0.3723	0.3723
Echinococcus multilocularis	neuropeptide receptor A26	0.0071	0.373	0.1611
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.2786	0.2786
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus multilocularis	G protein coupled receptor 139	0.0071	0.373	0.1611
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0071	0.373	0.1611
Brugia malayi	Protein kinase domain containing protein	0.0071	0.3723	0.3723
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0071	0.373	0.373
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.373	0.1611
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.1502	0.1502
Brugia malayi	GnHR receptor homolog	0.0071	0.373	0.373
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0122	0.8643	1
Loa Loa (eye worm)	norepinephrine transporter	0.0109	0.746	0.746
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Brugia malayi	putative neuropeptide receptor	0.0071	0.373	0.373
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0109	0.746	0.9644
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0071	0.373	0.4822
Brugia malayi	G-protein coupled receptor	0.0071	0.373	0.373
Echinococcus multilocularis	neuropeptide s receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	serotonin receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	7TM GPCR rhodopsin	0.0071	0.373	0.1611
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.373	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0109	0.746	0.746
Schistosoma mansoni	hypothetical protein	0.0071	0.373	0.4822
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	G protein coupled receptor 139	0.0071	0.373	0.1611
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.373	0.1611
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.2786	0.3602
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.373	0.373
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0071	0.373	0.001
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus granulosus	serotonin receptor	0.0071	0.373	0.1611
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0083	0.4845	0.3514
Brugia malayi	RE15519p	0.0071	0.373	0.373
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.373	0.1611
Brugia malayi	Dopamine receptor protein 1	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.1502	0.1502
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Echinococcus granulosus	allatostatin A receptor	0.0071	0.373	0.1611
Schistosoma mansoni	histamine h1 receptor	0.0071	0.373	0.4822
Echinococcus granulosus	g protein coupled receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0071	0.373	0.4822
Echinococcus multilocularis	dro:myosuppressin receptor	0.0071	0.373	0.1611
Onchocerca volvulus		0.0071	0.373	0.001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0071	0.373	0.373
Echinococcus multilocularis	somatostatin receptor	0.0071	0.373	0.1611
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Onchocerca volvulus		0.0071	0.373	0.001
Schistosoma mansoni	neuropeptide receptor	0.0071	0.373	0.4822
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.373	0.1611
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus granulosus	neuropeptide receptor A26	0.0071	0.373	0.1611
Echinococcus multilocularis	fmrfamide receptor	0.0071	0.373	0.1611
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0071	0.373	0.373
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0071	0.373	0.4822
Echinococcus granulosus	dro:myosuppressin receptor	0.0071	0.373	0.1611
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	serotonin transporter	0.0109	0.746	0.7979
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0071	0.373	0.4822
Schistosoma mansoni	adenoreceptor	0.0071	0.373	0.4822
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0071	0.373	0.1611
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0112	0.7735	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0071	0.373	0.1611
Schistosoma mansoni	neuropeptide f receptor 76f	0.0071	0.373	0.4822
Echinococcus granulosus	g protein coupled receptor	0.0071	0.373	0.1611
Schistosoma mansoni	metabotropic glutamate receptor	0.0048	0.1462	0.189
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0071	0.373	0.4822
Schistosoma mansoni	amine GPCR	0.0071	0.373	0.4822
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.373	0.1611
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0089	0.5504	0.5504
Brugia malayi	AKH receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0049	0.1502	0.1502
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.373	0.1611
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.373	0.1611
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.373	0.4822
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0109	0.746	0.746
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0099	0.6412	0.6412
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Brugia malayi	RNA binding protein	0.0062	0.2786	0.2786
Onchocerca volvulus		0.0071	0.373	0.001
Loa Loa (eye worm)	RNA binding protein	0.0062	0.2786	0.2786
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.2786	0.3602
Loa Loa (eye worm)	TYRA-2 protein	0.0071	0.373	0.373
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0071	0.373	0.373
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Brugia malayi	ORL1-like opioid receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0135	1	1
Brugia malayi	Dopamine receptor protein 2	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	biogenic amine receptor	0.0071	0.373	0.4822
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0071	0.373	0.1611
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0071	0.373	0.373
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.1502	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0071	0.373	0.1611
Echinococcus multilocularis	serotonin transporter	0.0109	0.746	0.7979
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.2786	0.3602
Onchocerca volvulus		0.0109	0.746	0.5952
Brugia malayi	G protein-coupled receptor F59B2.13	0.0071	0.373	0.373
Echinococcus multilocularis	neuropeptides capa receptor	0.0071	0.373	0.1611
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	7tm_1 domain containing protein	0.0071	0.373	0.1611
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0071	0.373	0.1611
Schistosoma mansoni	hypothetical protein	0.0071	0.373	0.4822
Echinococcus multilocularis	neuropeptide receptor	0.0071	0.373	0.1611
Brugia malayi	TAR-binding protein	0.0062	0.2786	0.2786
Echinococcus granulosus	neuropeptide Y receptor	0.0071	0.373	0.1611
Onchocerca volvulus		0.0071	0.373	0.001
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0071	0.373	0.4822
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Treponema pallidum	sodium- and chloride- dependent transporter	0.0109	0.746	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Echinococcus granulosus	g protein coupled receptor	0.0071	0.373	0.1611
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0071	0.373	0.373
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0071	0.373	0.1611
Onchocerca volvulus	Huntingtin homolog	0.0135	1	1
Onchocerca volvulus		0.0071	0.373	0.001
Schistosoma mansoni	neuropeptide receptor	0.0071	0.373	0.4822
Schistosoma mansoni	metabotropic glutamate receptor	0.0083	0.4845	0.6263
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.373	0.4822
Echinococcus granulosus	neuropeptides capa receptor	0.0071	0.373	0.1611
Brugia malayi	larval opioid receptor	0.0071	0.373	0.373
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	amine GPCR	0.0071	0.373	0.4822
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0071	0.373	0.001
Brugia malayi	Serotonin receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.2786	0.2786
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.2786	0.2786
Trichomonas vaginalis	CAMK family protein kinase	0.0071	0.3723	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.373	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.373	0.1611
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus granulosus	tm gpcr rhodopsin	0.0071	0.373	0.1611
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.2786	0.3602
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	serotonin receptor	0.0071	0.373	0.1611
Schistosoma mansoni	amine GPCR	0.0071	0.373	0.4822
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0071	0.373	0.1611
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	biogenic amine receptor	0.0071	0.373	0.4822
Schistosoma mansoni	growth hormone secretagogue receptor	0.0071	0.373	0.4822
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0071	0.373	0.4822
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.373	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	amine GPCR	0.0071	0.373	0.4822
Brugia malayi	putative neuropeptide receptor NPR1	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0135	1	1
Echinococcus multilocularis	allatostatin A receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0071	0.373	0.1611
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Brugia malayi	follicle stimulating hormone receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0109	0.746	0.746
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0071	0.373	0.4822
Loa Loa (eye worm)	glutamate receptor	0.0099	0.6412	0.6412
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0071	0.373	0.373
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0122	0.8643	0.8643
Brugia malayi	Melatonin receptor type 1A	0.0071	0.373	0.373
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.373	0.1611
Loa Loa (eye worm)	melatonin receptor type 1A	0.0071	0.373	0.373
Brugia malayi	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	serotonin transporter b	0.0109	0.746	0.746
Schistosoma mansoni	myosin xvIII	0.0071	0.373	0.4822
Schistosoma mansoni	opsin-like receptor	0.0071	0.373	0.4822
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Echinococcus multilocularis	orexin receptor type 2	0.0071	0.373	0.1611
Onchocerca volvulus		0.0071	0.373	0.001
Schistosoma mansoni	neuropeptide receptor	0.0071	0.373	0.4822
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.373	0.1611
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	hypothetical protein	0.0071	0.373	0.4822
Trichomonas vaginalis	CAMK family protein kinase	0.0071	0.3723	0.5
Brugia malayi	Serotonin receptor	0.0071	0.373	0.373
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0071	0.373	0.4822
Echinococcus granulosus	neuropeptide s receptor	0.0071	0.373	0.1611
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0071	0.373	0.1611
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.2786	0.3602
Echinococcus multilocularis	dual specificity serine:threonine tyrosine	0.0071	0.3723	0.16
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Brugia malayi	neuropeptide F receptor	0.0071	0.373	0.373
Echinococcus multilocularis	g protein coupled receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	G-protein coupled receptor	0.0071	0.373	0.373
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Brugia malayi	neuropeptide F receptor	0.0071	0.373	0.373
Echinococcus granulosus	hypothetical protein	0.0071	0.373	0.1611
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Onchocerca volvulus		0.0071	0.373	0.001
Echinococcus multilocularis	sex peptide receptor	0.0071	0.373	0.1611
Echinococcus granulosus	neuropeptide receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Giardia lamblia	Kinase, TTK	0.0071	0.3723	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0071	0.373	0.1611
Echinococcus granulosus	dual specificity serine:threonine tyrosine	0.0071	0.3723	0.16
Brugia malayi	G protein-coupled receptor	0.0071	0.373	0.373
Onchocerca volvulus	Huntingtin homolog	0.0135	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Loa Loa (eye worm)	glutamate receptor	0.0039	0.0554	0.0554
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0071	0.373	0.1611
Echinococcus granulosus	sex peptide receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0071	0.373	0.1611
Loa Loa (eye worm)	neuropeptide F receptor	0.0071	0.373	0.373
Echinococcus granulosus	neuropeptide receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0083	0.4845	0.3514
Schistosoma mansoni	amine GPCR	0.0071	0.373	0.4822
Schistosoma mansoni	neuropeptide F-like receptor	0.0071	0.373	0.4822
Echinococcus granulosus	somatostatin receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Onchocerca volvulus		0.0071	0.373	0.001
Brugia malayi	G-protein coupled receptor	0.0071	0.373	0.373
Brugia malayi	Dopamine receptor	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus granulosus	biogenic amine 5HT receptor	0.0071	0.373	0.1611
Schistosoma mansoni	biogenic amine receptor	0.0071	0.373	0.4822
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Schistosoma mansoni	sodium/chloride dependent transporter	0.0109	0.746	0.9644
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Brugia malayi	sulfakinin receptor protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0109	0.746	0.746
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0122	0.8643	1
Schistosoma mansoni	dual specificity serine/threonine tyrosine kinase	0.0071	0.3723	0.4814
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Loa Loa (eye worm)	hypothetical protein	0.0071	0.373	0.373
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0071	0.373	0.4822
Echinococcus granulosus	g-protein coupled receptor	0.0071	0.373	0.1611
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0071	0.373	0.373
Echinococcus multilocularis	g-protein coupled receptor	0.0071	0.373	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0109	0.746	0.746
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0071	0.373	0.4822
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0071	0.373	0.1611
Echinococcus granulosus	fmrfamide receptor	0.0071	0.373	0.1611
Echinococcus multilocularis	neuropeptide Y receptor	0.0071	0.373	0.1611
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0071	0.373	0.4822
Schistosoma mansoni	opsin-like receptor	0.0071	0.373	0.4822
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0071	0.373	0.373

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 420 nM	Displacement of [3H]-WIN- 35 428 binding at dopamine transporter(DAT) in rat caudate putamen	ChEMBL.	11728190

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3084933

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1816981