TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 374.403 | Formula: C20H21F3N4
H donors: 0 H acceptors: 2 LogP: 4.25 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cc(c(n1c1cccc(c1)C(F)(F)F)C)c1nnc2n1CCCCC2
InChi: 1S/C20H21F3N4/c1-13-11-17(19-25-24-18-9-4-3-5-10-26(18)19)14(2)27(13)16-8-6-7-15(12-16)20(21,22)23/h6-8,11-12H,3-5,9-10H2,1-2H3
InChiKey: PPPSKWGJGYDJPC-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	aldehyde dehydrogenase 1 family, member A1	Starlite/ChEMBL	References
Homo sapiens	hydroxyprostaglandin dehydrogenase 15-(NAD)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania braziliensis	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania donovani	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Neospora caninum	hypothetical protein	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium ulcerans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania mexicana	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Toxoplasma gondii	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma mansoni	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	Mitochondrial aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Retinal dehydrogenase 1, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania infantum	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Schistosoma japonicum	Aldehyde dehydrogenase X, mitochondrial precursor, putative	Get druggable targets OG5_126638	All targets in OG5_126638
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	Get druggable targets OG5_126638	All targets in OG5_126638
Candida albicans	aldehyde dehydrogenase	Get druggable targets OG5_126638	All targets in OG5_126638

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	steroid dehydrogenase, putative	hydroxyprostaglandin dehydrogenase 15-(NAD)	266 aa	216 aa	22.2 %
Mycobacterium tuberculosis	Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1	aldehyde dehydrogenase 1 family, member A1	501 aa	456 aa	33.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Schistosoma mansoni	ephrin receptor	0.04	0.4353	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.04	0.4353	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.04	0.4353	1
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0138	0.0218
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0377	0.0866
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0044	0.0102
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.4353	1
Loa Loa (eye worm)	TK/Met protein kinase	0.04	0.4353	1
Schistosoma mansoni	serine/threonine protein kinase	0.04	0.4353	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.04	0.4353	0.4353
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.04	0.4353	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0377	0.0866
Trichomonas vaginalis	protein kinase atn1, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.04	0.4353	1
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0044	0.0044
Echinococcus multilocularis	tyrosine protein kinase shark	0.04	0.4353	0.4353
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0282	0.0552
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.0282	0.0648
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.04	0.4353	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0044	0.0102
Leishmania major	protein kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.04	0.4353	1
Echinococcus granulosus	tyrosine kinase	0.04	0.4353	1
Echinococcus multilocularis	epidermal growth factor receptor	0.04	0.4353	0.4353
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.0282	0.0841
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0377	0.0377
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0429	0.0984
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.04	0.4353	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0377	0.0866
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.04	0.4353	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0282	0.0552
Plasmodium falciparum	protein kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein, conserved	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.04	0.4353	1
Brugia malayi	beta-lactamase family protein	0.0042	0.0282	0.0648
Echinococcus multilocularis	tyrosine protein kinase Abl	0.04	0.4353	0.4353
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.04	0.4353	0.4353
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0636	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0044	0.0102
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0377	0.0866
Mycobacterium ulcerans	lipase LipD	0.0042	0.0282	0.402
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	integrin-linked kinase	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Brugia malayi	C-terminal src kinase protein 1	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Plasmodium falciparum	tyrosine kinase-like protein	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.04	0.4353	0.4353
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.0282	0.0841
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.0282	0.0841
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.04	0.4353	0.4353
Echinococcus granulosus	retinal guanylyl cyclase 2	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	receptor protein kinase, putative	0.04	0.4353	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Toxoplasma gondii	ABC1 family protein	0.0042	0.0282	0.0342
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Brugia malayi	SRC-1	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.04	0.4353	0.4353
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.04	0.4353	1
Echinococcus granulosus	epidermal growth factor receptor	0.04	0.4353	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.04	0.4353	0.4353
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.04	0.4353	1
Echinococcus multilocularis	protein kinase	0.04	0.4353	0.4353
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Brugia malayi	hypothetical protein	0.04	0.4353	1
Schistosoma mansoni	serine/threonine protein kinase	0.04	0.4353	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.04	0.4353	0.4353
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.04	0.4353	0.4353
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Schistosoma mansoni	protein tyrosine kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.04	0.4353	0.4353
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0377	0.0866
Onchocerca volvulus		0.04	0.4353	1
Echinococcus multilocularis	integrin linked protein kinase	0.04	0.4353	0.4353
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0282	0.0552
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0044	0.0102
Loa Loa (eye worm)	serine/threonine protein kinase	0.04	0.4353	1
Entamoeba histolytica	receptor protein kinase, putative	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.04	0.4353	0.4353
Entamoeba histolytica	serine/threonine kinase, putative	0.04	0.4353	1
Brugia malayi	hypothetical protein	0.0019	0.0019	0.0043
Brugia malayi	ephrin receptor 1 precursor	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.04	0.4353	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.027	0.2872	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.04	0.4353	0.4353
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.04	0.4353	0.4353
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.04	0.4353	0.4353
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Toxoplasma gondii	protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.4353	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0282	0.0648
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase csk	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.04	0.4353	0.4353
Schistosoma mansoni	hypothetical protein	0.04	0.4353	1
Trypanosoma brucei	protein kinase, putative	0.04	0.4353	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.04	0.4353	0.4353
Echinococcus granulosus	tyrosine protein kinase HCK	0.04	0.4353	1
Brugia malayi	hypothetical protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.04	0.4353	0.4353
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Schistosoma mansoni	ephrin receptor	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.04	0.4353	1
Echinococcus granulosus	activated cdc42 kinase 1	0.04	0.4353	1
Trypanosoma cruzi	protein kinase, putative	0.04	0.4353	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.0282	0.0648
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	serine/threonine kinase, putative	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase shark	0.04	0.4353	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0636	0.1461
Echinococcus granulosus	tyrosine protein kinase csk	0.04	0.4353	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.04	0.4353	0.4353
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.4353	1
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0282	0.0841
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.04	0.4353	1
Trypanosoma brucei	Pseudokinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.04	0.4353	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Mycobacterium leprae	Probable lipase LipE	0.0042	0.0282	0.5
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.023	0.0529
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0282	0.0648
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus granulosus	epidermal growth factor receptor	0.04	0.4353	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Giardia lamblia	Kinase, NEK	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.04	0.4353	1
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0044	0.0044
Trichomonas vaginalis	esterase, putative	0.0042	0.0282	0.0552
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.04	0.4353	1
Echinococcus granulosus	insulin receptor	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase csk	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	Receptor family ligand binding region containing protein	0.04	0.4353	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0282	0.0552
Entamoeba histolytica	serine/threonine kinase, putative	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0042	0.0282	0.402
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	serine/threonine kinase, putative	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.04	0.4353	0.4353
Plasmodium falciparum	tyrosine kinase-like protein	0.04	0.4353	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.04	0.4353	0.4353
Entamoeba histolytica	ankyrin repeat protein	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	beta-lactamase	0.0042	0.0282	0.0648
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0073	0.0636	0.1461
Echinococcus granulosus	activin receptor type	0.04	0.4353	1
Echinococcus multilocularis	activin receptor type	0.04	0.4353	0.4353
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trichomonas vaginalis	TK family protein kinase	0.04	0.4353	1
Echinococcus granulosus	protein tyrosine kinase	0.04	0.4353	1
Brugia malayi	Furin-like cysteine rich region family protein	0.04	0.4353	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0044	0.0102
Echinococcus multilocularis	tyrosine kinase	0.04	0.4353	0.4353
Echinococcus granulosus	retinal guanylyl cyclase 2	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.04	0.4353	1
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0044	0.0102
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0044	0.0102
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Toxoplasma gondii	protein kinase domain-containing protein	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	protein-tyrosine kinase	0.04	0.4353	1
Brugia malayi	hypothetical protein	0.003	0.0138	0.0317
Giardia lamblia	Kinase, NEK	0.04	0.4353	1
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.0282	0.0552
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.04	0.4353	0.4353
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.04	0.4353	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0044	0.0102
Echinococcus multilocularis	tyrosine protein kinase	0.04	0.4353	0.4353
Onchocerca volvulus		0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.04	0.4353	1
Leishmania major	hypothetical protein, conserved	0.003	0.0138	0.0218
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0138	0.0218
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.04	0.4353	0.4353
Echinococcus granulosus	tyrosine protein kinase pr2	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0073	0.0636	0.1373
Entamoeba histolytica	serine/threonine kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0429	0.0984
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0636	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.04	0.4353	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.04	0.4353	1
Schistosoma mansoni	serine/threonine protein kinase	0.04	0.4353	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.04	0.4353	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.0282	0.0552
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.04	0.4353	0.4353
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.04	0.4353	0.4353
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Leishmania major	hypothetical protein, conserved	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	tyrosin kinase, putative	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Schistosoma mansoni	hypothetical protein	0.0038	0.023	0.0529
Toxoplasma gondii	STE kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0377	0.0866
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.04	0.4353	1
Entamoeba histolytica	tyrosin kinase, putative	0.04	0.4353	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0377	0.0866
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Echinococcus granulosus	protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Echinococcus granulosus	tyrosine kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.04	0.4353	0.4353
Loa Loa (eye worm)	RGC/RGC protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0044	0.0102
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0282	0.0648
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.04	0.4353	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.04	0.4353	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0073	0.0636	0.2092
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0282	0.0648
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0377	0.0377
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.04	0.4353	0.4353
Onchocerca volvulus		0.04	0.4353	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.04	0.4353	0.4353
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.0282	0.0841
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	hypothetical protein	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0073	0.0636	0.0636
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.04	0.4353	0.4353
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.0282	0.0552
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Loa Loa (eye worm)	SRC-1	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0073	0.0636	0.1181
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Echinococcus multilocularis	transfer RNA-Thr	0.04	0.4353	0.4353
Trypanosoma cruzi	protein kinase, putative	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.04	0.4353	0.4353
Schistosoma mansoni	serine/threonine RGC	0.04	0.4353	1
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.0282	0.5
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	beta-lactamase family protein	0.0042	0.0282	0.0648
Brugia malayi	Immunoglobulin I-set domain containing protein	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.04	0.4353	0.4353
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0073	0.0636	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.023	0.0529
Loa Loa (eye worm)	TK/DDR protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.04	0.4353	0.4353
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.04	0.4353	1
Echinococcus multilocularis	heat shock protein 70	0.04	0.4353	0.4353
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	cysteine surface protein, putative	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	serine/threonine kinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	AGC family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Leishmania major	hypothetical protein, conserved	0.0042	0.0282	0.0552
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.04	0.4353	1
Onchocerca volvulus	Tyrosine kinase homolog	0.04	0.4353	1
Entamoeba histolytica	ankyrin repeat protein	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Schistosoma mansoni	serine/threonine protein kinase	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.04	0.4353	0.4353
Brugia malayi	bone morphogenetic protein type 1 receptor	0.04	0.4353	1
Entamoeba histolytica	tyrosin kinase, putative	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.04	0.4353	1
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.04	0.4353	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.0282	0.0648
Brugia malayi	Tyrosine-protein kinase PR2	0.04	0.4353	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.04	0.4353	1
Giardia lamblia	Protein 21.1	0.04	0.4353	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.0282	0.0648
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.4353	1
Trichomonas vaginalis	CAMK family protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	Guanylyl cyclase protein 23	0.04	0.4353	1
Echinococcus multilocularis	protein tyrosine kinase	0.04	0.4353	0.4353
Entamoeba histolytica	protein kinase domain containing protein	0.04	0.4353	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0042	0.0282	0.402
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	Raf kinase	0.04	0.4353	1
Echinococcus multilocularis	c src tyrosine kinase	0.04	0.4353	0.4353
Loa Loa (eye worm)	TK/RYK protein kinase	0.04	0.4353	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.04	0.4353	1
Echinococcus granulosus	dna polymerase eta	0.0021	0.0044	0.0102
Entamoeba histolytica	hypothetical protein	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Plasmodium falciparum	protein kinase, putative	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.04	0.4353	1
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0429	0.0984
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.04	0.4353	1
Echinococcus multilocularis	epidermal growth factor receptor	0.04	0.4353	0.4353
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.04	0.4353	0.4353
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0282	0.0648
Loa Loa (eye worm)	hypothetical protein	0.003	0.0138	0.0317
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Echinococcus granulosus	c src tyrosine kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.04	0.4353	1
Onchocerca volvulus		0.04	0.4353	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.04	0.4353	1
Giardia lamblia	Kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK protein kinase	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.04	0.4353	0.4353
Mycobacterium ulcerans	beta-lactamase	0.0042	0.0282	0.402
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.0282	0.0841
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.0282	0.0552
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus granulosus	activated cdc42 kinase 1	0.04	0.4353	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.04	0.4353	0.4353
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.04	0.4353	0.4353
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.0282	0.0282
Echinococcus multilocularis	insulin receptor	0.04	0.4353	0.4353
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Echinococcus multilocularis	FL cytokine receptor	0.04	0.4353	0.4353
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0138	0.0218
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.0282	0.0841
Entamoeba histolytica	tyrosin kinase, putative	0.04	0.4353	1
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0282	0.0342
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Echinococcus multilocularis	tyrosine kinase	0.04	0.4353	0.4353
Loa Loa (eye worm)	TK/FAK protein kinase	0.04	0.4353	1
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0282	0.402
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Brugia malayi	beta-lactamase	0.0042	0.0282	0.0648
Plasmodium vivax	protein kinase, putative	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0429	0.0984
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.04	0.4353	1
Schistosoma mansoni	protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.04	0.4353	0.4353
Echinococcus multilocularis	activated cdc42 kinase 1	0.04	0.4353	0.4353
Leishmania major	protein kinase, putative	0.04	0.4353	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.04	0.4353	1
Plasmodium falciparum	protein kinase, putative	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0282	0.0841
Schistosoma mansoni	tyrosine protein kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.04	0.4353	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0073	0.0636	0.1461
Brugia malayi	SH2 domain containing protein	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0282	0.0648
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Schistosoma mansoni	tyrosine kinase	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.04	0.4353	1
Echinococcus granulosus	tyrosine kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.04	0.4353	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.04	0.4353	0.4353
Mycobacterium tuberculosis	Conserved protein	0.0042	0.0282	0.0841
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Entamoeba histolytica	protein kinase, putative	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.04	0.4353	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.04	0.4353	1
Trichomonas vaginalis	conserved hypothetical protein	0.04	0.4353	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.04	0.4353	1
Brugia malayi	SH2 domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	hypothetical protein	0.04	0.4353	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.04	0.4353	0.4353
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0282	0.0648
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.04	0.4353	0.4353
Echinococcus granulosus	tyrosine protein kinase Fyn	0.04	0.4353	1
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.04	0.4353	0.4353
Brugia malayi	Protein kinase domain containing protein	0.04	0.4353	1
Trichomonas vaginalis	STE family protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.04	0.4353	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.04	0.4353	1
Echinococcus multilocularis	protein kinase	0.04	0.4353	0.4353
Echinococcus granulosus	ephrin type A receptor 4 A	0.04	0.4353	1
Entamoeba histolytica	tyrosine kinase, putative	0.04	0.4353	1
Echinococcus granulosus	integrin linked protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.04	0.4353	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.0282	0.0841
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.04	0.4353	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.04	0.4353	0.4353
Loa Loa (eye worm)	TK/FER protein kinase	0.04	0.4353	1
Trichomonas vaginalis	TKL family protein kinase	0.04	0.4353	1

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	= 2.22 uM	Induction of PGE2 production in human LNCAP cells assessed as half-maximal activation concentration after 16 hrs by HTRF assay	ChEMBL.	24360556
Activity (functional)	= 44 %	Induction of PGE2 production in human LNCAP cells at 41.9 nM to 100 uM after 16 hrs by HTRF assay relative to control	ChEMBL.	24360556
IC50 (binding)		Inhibition of rabbit muscle GAPDH using glyceraldehyde-3-phosphate as substrate at 324 pM to 57.2 uM by fluorescence assay	ChEMBL.	24360556
IC50 (binding)		Inhibition of LDHA (unknown origin) using sodium pyruvate as substrate at 0.46 to 57.5 uM after 15 mins by fluorescence assay	ChEMBL.	24360556
IC50 (binding)		Inhibition of HSD17beta4 (unknown origin) using NAD+/estradiol as substrate at 324 pM to 57.2 uM after 15 mins by UV-fluorescence assay	ChEMBL.	24360556
IC50 (binding)		Inhibition of LDHB (unknown origin) using sodium pyruvate as substrate at 0.46 to 57.5 uM after 15 mins by fluorescence assay	ChEMBL.	24360556
IC50 (binding)	= 48 nM	Inhibition of human HPGD using PGE2 as substrate after 15 mins by fluorescence assay	ChEMBL.	24360556
IC50 (binding)	= 1524 nM	Inhibition of ALDH1A1 (unknown origin) using NAD+/propionaldehyde as substrate after 15 mins by UV-fluorescence assay	ChEMBL.	24360556
Potency (functional)	0.0482 uM	PubChem BioAssay. Extended Characterization of HPGD Inhibitors: Activity in Primary Assay (HPGD). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24360556

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3102998

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1817355