Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.4446 | 0.4769 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.1195 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0166 | 0.0123 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.1452 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0995 | 0.1188 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1195 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.007 | 0.7374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4118 | 0.4413 |
Brugia malayi | Bromodomain containing protein | 0.0045 | 0.37 | 0.2845 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.3712 | 0.3972 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0042 | 0.3293 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0166 | 0.0123 |
Schistosoma mansoni | bromodomain containing protein | 0.0074 | 0.7988 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0166 | 0.0123 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0024 | 0.0667 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0166 | 0.0123 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1195 | 1 |
Brugia malayi | PHD-finger family protein | 0.0029 | 0.1401 | 0.0234 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1452 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0029 | 0.1452 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.1195 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0042 | 0.3293 | 0.4427 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.007 | 0.7374 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1195 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0995 | 0.1287 |
Schistosoma mansoni | zinc finger protein | 0.0023 | 0.0486 | 0.0546 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1452 | 0.5 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0166 | 0.5 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.1195 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0024 | 0.0667 | 0.0774 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.1195 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.1195 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0029 | 0.1452 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0166 | 0.0123 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.1452 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1195 | 0.124 |
Echinococcus granulosus | zinc finger protein | 0.0023 | 0.0486 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1195 | 0.124 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.1452 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0029 | 0.1452 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.9266 | 1 |
Brugia malayi | hypothetical protein | 0.0029 | 0.1452 | 0.0292 |
Echinococcus multilocularis | zinc finger protein | 0.0023 | 0.0486 | 0.0592 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1195 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.1195 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1195 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1195 | 0.5 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0995 | 0.1287 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0166 | 0.139 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1195 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.1195 | 1 |
Onchocerca volvulus | 0.0028 | 0.1195 | 0.5 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.1195 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1452 | 0.1519 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1195 | 0.124 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0158 | 0.0114 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 18.02 uM | Cytotoxicity against human KB cells by SRB assay | ChEMBL. | 24315191 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.