TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 314.382 | Formula: C17H22N4O2
H donors: 2 H acceptors: 3 LogP: 1.55 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC[C@@H]([C@@H](C(=O)N)NC(=O)c1cccc(c1)Cn1cncc1)C
InChi: 1S/C17H22N4O2/c1-3-12(2)15(16(18)22)20-17(23)14-6-4-5-13(9-14)10-21-8-7-19-11-21/h4-9,11-12,15H,3,10H2,1-2H3,(H2,18,22)(H,20,23)/t12-,15-/m0/s1
InChiKey: BMTCVBWFZVHMIP-WFASDCNBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0279	0.3253	0.3038
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0654	0.2057
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0273	0.3179	1
Loa Loa (eye worm)	TK protein kinase	0.0279	0.3253	1
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0279	0.3253	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0279	0.3253	1
Brugia malayi	Protein kinase domain containing protein	0.0279	0.3253	1
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0273	0.3179	0.9746
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0273	0.3179	0.296
Loa Loa (eye worm)	TK/CSK protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0279	0.3253	0.3038
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0273	0.3179	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0273	0.3179	0.9746
Toxoplasma gondii	STE kinase	0.0273	0.3179	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0279	0.3253	0.3038
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0279	0.3253	1
Echinococcus multilocularis	geminin	0.0168	0.1818	0.1556
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0273	0.3179	0.9746
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0137	0.1417	0.2935
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0279	0.3253	1
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0273	0.3179	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0273	0.3179	0.9746
Echinococcus granulosus	protein tyrosine kinase	0.0273	0.3179	0.9746
Echinococcus multilocularis	tyrosine protein kinase csk	0.0273	0.3179	0.296
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0273	0.3179	0.9712
Toxoplasma gondii	protein kinase	0.0273	0.3179	1
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0137	0.1417	0.376
Loa Loa (eye worm)	TK/FAK protein kinase	0.0273	0.3179	0.9712
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0654	0.5
Schistosoma mansoni	hypothetical protein	0.0168	0.1818	0.4477
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0279	0.3253	0.3038
Echinococcus granulosus	tyrosine protein kinase csk	0.0273	0.3179	0.9746
Leishmania major	protein kinase, putative	0.0273	0.3179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase	0.0273	0.3179	0.296
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0273	0.3179	0.9746
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	0.3179	0.9712
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0279	0.3253	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0273	0.3179	0.9746
Loa Loa (eye worm)	serine/threonine protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	ephrin receptor	0.0273	0.3179	0.9712
Loa Loa (eye worm)	SRC-1	0.0279	0.3253	1
Onchocerca volvulus		0.0279	0.3253	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0279	0.3253	0.3038
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0273	0.3179	0.9712
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0654	0.5
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Brugia malayi	SRC-1	0.0279	0.3253	1
Echinococcus granulosus	integrin linked protein kinase	0.0273	0.3179	0.9746
Giardia lamblia	Protein 21.1	0.0273	0.3179	0.5
Brugia malayi	ephrin receptor 1 precursor	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0279	0.3253	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0137	0.1417	0.2935
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0273	0.3179	0.9746
Echinococcus granulosus	epidermal growth factor receptor	0.0273	0.3179	0.9746
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Schistosoma mansoni	hypothetical protein	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0152	0.1621	0.4453
Trichomonas vaginalis	pps1 dual specificty phosphatase, putative	0.067	0.829	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0654	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0279	0.3253	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0273	0.3179	0.9712
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0273	0.3179	1
Onchocerca volvulus		0.0279	0.3253	1
Echinococcus granulosus	insulin receptor	0.0273	0.3179	0.9746
Brugia malayi	protein-tyrosine kinase	0.0279	0.3253	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0273	0.3179	0.9746
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0654	0.5
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.031	0.5
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine kinase	0.0279	0.3253	1
Echinococcus multilocularis	c src tyrosine kinase	0.0279	0.3253	0.3038
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0273	0.3179	0.9746
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0273	0.3179	0.296
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Echinococcus granulosus	natriuretic peptide receptor 1	0.0273	0.3179	0.9746
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0273	0.3179	0.9746
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0279	0.3253	1
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Brugia malayi	Tyrosine-protein kinase abl-1	0.0279	0.3253	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0273	0.3179	0.296
Echinococcus multilocularis	protein kinase	0.0273	0.3179	0.296
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0273	0.3179	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0279	0.3253	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0279	0.3253	0.3038
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0273	0.3179	0.296
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Brugia malayi	Raf kinase	0.0273	0.3179	0.9712
Plasmodium falciparum	protein kinase, putative	0.0273	0.3179	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0273	0.3179	1
Plasmodium vivax	protein kinase, putative	0.0273	0.3179	1
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/ALK protein kinase	0.0273	0.3179	0.9712
Brugia malayi	SH2 domain containing protein	0.0279	0.3253	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0654	0.2057
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0279	0.3253	0.3038
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0273	0.3179	0.296
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0279	0.3253	1
Brugia malayi	SH2 domain containing protein	0.0279	0.3253	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase shark	0.0279	0.3253	0.3038
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0273	0.3179	0.296
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0273	0.3179	0.296
Brugia malayi	Receptor family ligand binding region containing protein	0.0273	0.3179	0.9712
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0273	0.3179	0.296
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0273	0.3179	0.9712
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0077	0.0654	0.2057
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0273	0.3179	0.9746
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0279	0.3253	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0273	0.3179	0.9746
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0273	0.3179	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0273	0.3179	0.9712
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0273	0.3179	0.9746
Schistosoma mansoni	ephrin receptor	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/DDR protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0152	0.1621	0.4453
Schistosoma mansoni	serine/threonine RGC	0.0273	0.3179	0.9712
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0273	0.3179	0.5
Brugia malayi	Furin-like cysteine rich region family protein	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0273	0.3179	0.296
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0273	0.3179	0.9712
Schistosoma mansoni	serine/threonine protein kinase	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0273	0.3179	0.9746
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0279	0.3253	0.3038
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0273	0.3179	0.9712
Echinococcus granulosus	activated cdc42 kinase 1	0.0273	0.3179	0.9746
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0077	0.0654	0.1168
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Entamoeba histolytica	dual specificity protein phosphatase, putative	0.067	0.829	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Schistosoma mansoni	serine/threonine protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0273	0.3179	0.296
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/INSR protein kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0273	0.3179	0.9746
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0279	0.3253	0.3038
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0273	0.3179	0.296
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	activated cdc42 kinase 1	0.0273	0.3179	0.296
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0273	0.3179	0.9746
Schistosoma mansoni	tyrosine kinase	0.0279	0.3253	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0654	0.5
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Trypanosoma cruzi	protein kinase, putative	0.0273	0.3179	0.5
Leishmania major	protein kinase, putative	0.0273	0.3179	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0273	0.3179	0.296
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	epidermal growth factor receptor	0.0273	0.3179	0.9746
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0273	0.3179	0.296
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0279	0.3253	0.3038
Echinococcus multilocularis	FL cytokine receptor	0.0273	0.3179	0.296
Echinococcus multilocularis	tyrosine kinase	0.0279	0.3253	0.3038
Echinococcus multilocularis	integrin linked protein kinase	0.0273	0.3179	0.296
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0137	0.1417	0.2935
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0273	0.3179	0.9712
Onchocerca volvulus		0.0279	0.3253	1
Schistosoma mansoni	serine/threonine protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine protein kinase	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase	0.0273	0.3179	0.9746
Echinococcus granulosus	geminin	0.0168	0.1818	0.5122
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	insulin receptor	0.0273	0.3179	0.296
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase shark	0.0279	0.3253	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.031	0.5
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/RYK protein kinase	0.0273	0.3179	0.9712
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Brugia malayi	integrin-linked kinase	0.0273	0.3179	0.9712
Toxoplasma gondii	protein kinase domain-containing protein	0.0273	0.3179	1
Brugia malayi	C-terminal src kinase protein 1	0.0273	0.3179	0.9712
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0273	0.3179	0.9746
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0273	0.3179	0.9712
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0152	0.1621	0.3719
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0273	0.3179	0.296
Brugia malayi	Guanylyl cyclase protein 23	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0273	0.3179	0.9746
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Brugia malayi	Tyrosine-protein kinase PR2	0.0273	0.3179	0.9712
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0077	0.0654	0.2057
Echinococcus granulosus	tyrosine protein kinase csk	0.0273	0.3179	0.9746
Loa Loa (eye worm)	TK/EPH protein kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	protein kinase	0.0273	0.3179	0.9746
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0273	0.3179	0.296
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/ACK protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0273	0.3179	0.296
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0279	0.3253	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0273	0.3179	0.9746
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	activin receptor type	0.0273	0.3179	0.296
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Trypanosoma cruzi	protein kinase, putative	0.0273	0.3179	0.5
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0077	0.0654	0.0355
Echinococcus granulosus	tyrosine protein kinase csk	0.0273	0.3179	0.9746
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0273	0.3179	0.9746
Echinococcus granulosus	tyrosine protein kinase HCK	0.0273	0.3179	0.9746
Echinococcus multilocularis	epidermal growth factor receptor	0.0273	0.3179	0.296
Schistosoma mansoni	tyrosine kinase	0.0279	0.3253	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0273	0.3179	0.9712
Plasmodium falciparum	tyrosine kinase-like protein	0.0273	0.3179	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0273	0.3179	0.296
Brugia malayi	Protein kinase domain containing protein	0.0279	0.3253	1
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine kinase	0.0273	0.3179	0.296
Leishmania major	hypothetical protein, conserved	0.0273	0.3179	0.5
Giardia lamblia	Kinase, NEK	0.0273	0.3179	0.5
Brugia malayi	hypothetical protein	0.0279	0.3253	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0279	0.3253	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0279	0.3253	0.3038
Onchocerca volvulus		0.0279	0.3253	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0152	0.1621	0.1352
Echinococcus granulosus	tyrosine kinase	0.0273	0.3179	0.9746
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0273	0.3179	0.9746
Echinococcus granulosus	tyrosine kinase	0.0279	0.3253	1
Schistosoma mansoni	tyrosine kinase	0.0279	0.3253	1
Schistosoma mansoni	hypothetical protein	0.0168	0.1818	0.4477
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0279	0.3253	1
Trypanosoma brucei	Pseudokinase, putative	0.0273	0.3179	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0273	0.3179	0.296
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0273	0.3179	0.296
Loa Loa (eye worm)	TK protein kinase	0.0273	0.3179	0.9712
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.031	0.4744
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0273	0.3179	0.5
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0077	0.0654	1
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Onchocerca volvulus		0.0279	0.3253	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0273	0.3179	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0273	0.3179	0.9712
Brugia malayi	hypothetical protein	0.0273	0.3179	0.9712
Schistosoma mansoni	protein tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	transfer RNA-Thr	0.0273	0.3179	0.296
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0273	0.3179	0.296
Echinococcus granulosus	c src tyrosine kinase	0.0279	0.3253	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0279	0.3253	1
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Onchocerca volvulus		0.0279	0.3253	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0077	0.0654	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0279	0.3253	0.0146
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase csk	0.0273	0.3179	0.296
Brugia malayi	Protein kinase domain containing protein	0.0279	0.3253	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	heat shock protein 70	0.0273	0.3179	0.296
Loa Loa (eye worm)	hypothetical protein	0.0279	0.3253	1
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus granulosus	activin receptor type	0.0273	0.3179	0.9746
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0279	0.3253	0.3038
Trypanosoma brucei	protein kinase, putative	0.0273	0.3179	0.5
Loa Loa (eye worm)	TK/ABL protein kinase	0.0279	0.3253	1
Plasmodium falciparum	protein kinase, putative	0.0273	0.3179	1
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase csk	0.0273	0.3179	0.296
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0279	0.3253	0.3038
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0273	0.3179	0.296
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase Blk	0.0279	0.3253	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0152	0.1621	0.3719
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0152	0.1621	0.3719
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0137	0.1417	0.376
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0273	0.3179	0.9712
Echinococcus multilocularis	epidermal growth factor receptor	0.0273	0.3179	0.296
Echinococcus multilocularis	protein kinase	0.0273	0.3179	0.296
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0152	0.1621	0.3719
Brugia malayi	hypothetical protein	0.0273	0.3179	0.9712
Brugia malayi	Protein kinase domain containing protein	0.0279	0.3253	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0273	0.3179	0.9746
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0273	0.3179	0.9746
Schistosoma mansoni	protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0279	0.3253	0.3038
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0273	0.3179	0.296
Brugia malayi	Protein kinase domain containing protein	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0137	0.1417	0.1142
Brugia malayi	Protein kinase domain containing protein	0.0279	0.3253	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0273	0.3179	0.9712
Plasmodium falciparum	tyrosine kinase-like protein	0.0273	0.3179	1
Giardia lamblia	Kinase	0.0273	0.3179	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0279	0.3253	0.3038
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0137	0.1417	0.1142
Giardia lamblia	Kinase, NEK	0.0273	0.3179	0.5
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0279	0.3253	0.3038
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0273	0.3179	0.296
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0279	0.3253	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0152	0.1621	0.1352
Plasmodium falciparum	protein kinase, putative	0.0273	0.3179	1
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Schistosoma mansoni	tyrosine kinase	0.0273	0.3179	0.9712
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0279	0.3253	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0152	0.1621	0.3719
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0273	0.3179	0.9712
Loa Loa (eye worm)	hypothetical protein	0.0273	0.3179	0.9712
Loa Loa (eye worm)	TK/FER protein kinase	0.0279	0.3253	1
Echinococcus multilocularis	protein tyrosine kinase	0.0273	0.3179	0.296

Activities

Activity type	Assay description	Source	Reference
Activity (binding)	Binding affinity to AT1 receptor (unknown origin)	ChEMBL.	24388688
Inhibition (binding)	Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells at 1 uM	ChEMBL.	24388688
Inhibition (binding)	Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells at 10 uM	ChEMBL.	24388688
Ki (binding)	Displacement of [125I]CGP-42112A from human AT2 receptor expressed in HEK293 cells	ChEMBL.	24388688

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3105383

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1818294