TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 448.534 | Formula: C25H24N2O4S
H donors: 0 H acceptors: 4 LogP: 4.07 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC1CCN(CC1)S(=O)(=O)c1ccc2c(c1)C(=O)C(=O)N2Cc1ccc2c(c1)cccc2
InChi: 1S/C25H24N2O4S/c1-17-10-12-26(13-11-17)32(30,31)21-8-9-23-22(15-21)24(28)25(29)27(23)16-18-6-7-19-4-2-3-5-20(19)14-18/h2-9,14-15,17H,10-13,16H2,1H3
InChiKey: FANAPCIIMCNEBU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Echinococcus granulosus	importin subunit beta 1	0.0033	0.0005	0.0028
Brugia malayi	SPRY domain containing protein	0.0109	0.0405	0.0405
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Onchocerca volvulus		0.0135	0.0539	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Schistosoma mansoni	protein tyrosine phosphatase	0.0135	0.0539	0.326
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0109	0.0405	0.0405
Echinococcus granulosus	Netrin receptor DCC	0.0109	0.0405	0.2446
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0349	0.1654	0.1754
Schistosoma mansoni	hypothetical protein	0.0109	0.0405	0.2446
Onchocerca volvulus		0.0135	0.0539	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0005	0.0005
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0135	0.0539	0.0572
Echinococcus granulosus	titin	0.0109	0.0405	0.2446
Schistosoma mansoni	hypothetical protein	0.0109	0.0405	0.2446
Schistosoma mansoni	importin beta-1	0.0033	0.0005	0.0028
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Trichomonas vaginalis	pten, drome, putative	0.0135	0.0539	0.5
Toxoplasma gondii	HEAT repeat-containing protein	0.0033	0.0005	0.5
Echinococcus granulosus	usherin	0.0109	0.0405	0.2446
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0244	0.111	0.6709
Onchocerca volvulus		0.0135	0.0539	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Brugia malayi	hypothetical protein	0.0109	0.0405	0.0405
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Echinococcus granulosus	snurportin 1	0.0349	0.1654	1
Brugia malayi	myotactin form B	0.0109	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0109	0.0405	0.0429
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0244	0.111	0.6709
Schistosoma mansoni	factor for adipocyte differentiation	0.0109	0.0405	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0193	0.0204
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Echinococcus multilocularis	importin subunit beta 1	0.0033	0.0005	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Brugia malayi	hypothetical protein	0.004	0.0045	0.0045
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0135	0.0539	0.0539
Echinococcus multilocularis	titin	0.0109	0.0405	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Loa Loa (eye worm)	hypothetical protein	0.1702	0.8724	0.9252
Schistosoma mansoni	cell adhesion molecule	0.0109	0.0405	0.2446
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0109	0.0405	0.2446
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0109	0.0405	0.2446
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0109	0.0405	0.2446
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0244	0.111	0.6709
Brugia malayi	myotactin form A	0.0109	0.0405	0.0405
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0244	0.111	0.6709
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Onchocerca volvulus		0.0135	0.0539	0.0151
Onchocerca volvulus	4.1 G protein, putative homolog	0.0135	0.0539	0.0151
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Onchocerca volvulus		0.0135	0.0539	0.0151
Onchocerca volvulus		0.0135	0.0539	0.0151
Onchocerca volvulus		0.0135	0.0539	0.0151
Onchocerca volvulus		0.0135	0.0539	0.0151
Onchocerca volvulus		0.1811	0.9295	1
Brugia malayi	hypothetical protein	0.0135	0.0539	0.0539
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Schistosoma mansoni	tripartite motif protein trim9	0.0109	0.0405	0.2446
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Schistosoma mansoni	myosin-binding protein-related	0.0109	0.0405	0.2446
Schistosoma mansoni	titin	0.0109	0.0405	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0244	0.111	0.6709
Loa Loa (eye worm)	hypothetical protein	0.01	0.0359	0.038
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus multilocularis	roundabout 2	0.0109	0.0405	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Onchocerca volvulus		0.0135	0.0539	0.0151
Schistosoma mansoni	factor for adipocyte differentiation	0.0109	0.0405	0.2446
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Schistosoma mansoni	hypothetical protein	0.0349	0.1654	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0109	0.0405	0.0429
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Schistosoma mansoni	protein tyrosine phosphatase	0.0244	0.111	0.6709
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0109	0.0405	0.0429
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0109	0.0405	0.0405
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0045	0.027
Echinococcus multilocularis	anosmin 1	0.0109	0.0405	0.2446
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Plasmodium falciparum	importin beta, putative	0.0033	0.0005	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Echinococcus multilocularis	usherin	0.0109	0.0405	0.2446
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0244	0.111	0.6709
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Onchocerca volvulus		0.0135	0.0539	0.0151
Onchocerca volvulus		0.0135	0.0539	0.0151
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0244	0.111	0.1177
Echinococcus granulosus	Netrin receptor DCC	0.0109	0.0405	0.2446
Brugia malayi	Fibronectin type III domain containing protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0135	0.0539	0.0572
Schistosoma mansoni	hypothetical protein	0.004	0.0045	0.027
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0109	0.0405	0.2446
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0244	0.111	0.6709
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0109	0.0405	0.0429
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0135	0.0539	0.326
Onchocerca volvulus		0.0135	0.0539	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0135	0.0539	0.0539
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Brugia malayi	protein unc-22	0.0109	0.0405	0.0405
Loa Loa (eye worm)	lethal protein 805	0.0109	0.0405	0.0429
Onchocerca volvulus		0.0135	0.0539	0.0151
Schistosoma mansoni	hemicentin	0.0109	0.0405	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0109	0.0405	0.2446
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.0193	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus granulosus	roundabout 2	0.0109	0.0405	0.2446
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0244	0.111	0.6709
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0135	0.0539	0.326
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0135	0.0539	0.326
Brugia malayi	Importin beta-1 subunit	0.0033	0.0005	0.0005
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0135	0.0539	0.326
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0244	0.111	0.6709
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0109	0.0405	0.2446
Echinococcus multilocularis	snurportin 1	0.0349	0.1654	1
Echinococcus multilocularis	roundabout 2	0.0109	0.0405	0.2446
Echinococcus multilocularis	cell adhesion molecule	0.0109	0.0405	0.2446
Onchocerca volvulus		0.0135	0.0539	0.0151
Echinococcus granulosus	titin	0.0109	0.0405	0.2446
Brugia malayi	hypothetical protein	0.0135	0.0539	0.0539
Onchocerca volvulus		0.0135	0.0539	0.0151
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0244	0.111	0.6709
Leishmania major	tyrosine specific protein phosphatase, putative	0.0135	0.0539	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0109	0.0405	0.0429
Giardia lamblia	Protein tyrosine phosphatase	0.0135	0.0539	0.5
Echinococcus multilocularis	transfer RNA-Phe	0.0109	0.0405	0.2446
Echinococcus multilocularis	Fibronectin, type III	0.0109	0.0405	0.2446
Plasmodium vivax	importin-beta 2, putative	0.0033	0.0005	0.5
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Schistosoma mansoni	protein tyrosine phosphatase	0.0135	0.0539	0.326
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Brugia malayi	hypothetical protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.01	0.0359	0.038
Echinococcus multilocularis	anosmin 1	0.0109	0.0405	0.2446
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0109	0.0405	0.0405
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0109	0.0405	0.2446
Echinococcus multilocularis		0.0135	0.0539	0.326
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0244	0.111	0.6709
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Schistosoma mansoni	cell adhesion molecule	0.0109	0.0405	0.2446
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Schistosoma mansoni	cell adhesion molecule	0.0109	0.0405	0.2446
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Loa Loa (eye worm)	hypothetical protein	0.1837	0.9429	1
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0109	0.0405	0.0429
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0109	0.0405	0.2446
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0045	0.027
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0135	0.0539	0.326
Echinococcus granulosus	roundabout 2	0.0109	0.0405	0.2446
Echinococcus multilocularis	neuroglian	0.0109	0.0405	0.2446
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Schistosoma mansoni	serine/threonine protein kinase	0.0109	0.0405	0.2446
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0109	0.0405	0.0429
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0109	0.0405	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus granulosus	anosmin 1	0.0109	0.0405	0.2446
Echinococcus granulosus	cell adhesion molecule	0.0109	0.0405	0.2446
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0244	0.111	0.6709
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0135	0.0539	0.326
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	UNCoordinated family member	0.0109	0.0405	0.0429
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0109	0.0405	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Echinococcus multilocularis	Netrin receptor DCC	0.0109	0.0405	0.2446
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0135	0.0539	0.326
Brugia malayi	Fibronectin type III domain containing protein	0.0109	0.0405	0.0405
Schistosoma mansoni	cell adhesion molecule	0.0109	0.0405	0.2446
Brugia malayi	Protein-tyrosine phosphatase 1	0.0135	0.0539	0.0539
Schistosoma mansoni	hypothetical protein	0.0109	0.0405	0.2446
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0135	0.0539	0.0572
Echinococcus granulosus	EG95	0.0109	0.0405	0.2446
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0135	0.0539	0.326
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0135	0.0539	0.326
Brugia malayi	hypothetical protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Brugia malayi	Fibronectin type III domain containing protein	0.0109	0.0405	0.0405
Schistosoma mansoni	factor for adipocyte differentiation	0.0109	0.0405	0.2446
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0135	0.0539	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Brugia malayi	hypothetical protein	0.0135	0.0539	0.0539
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0135	0.0539	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0135	0.0539	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Brugia malayi	Fibronectin type III domain containing protein	0.0109	0.0405	0.0405
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0135	0.0539	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Brugia malayi	Lethal protein 805	0.0109	0.0405	0.0405
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0135	0.0539	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0135	0.0539	0.326
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Echinococcus multilocularis	titin	0.0109	0.0405	0.2446
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0135	0.0539	0.326
Loa Loa (eye worm)	hypothetical protein	0.1702	0.8724	0.9252
Loa Loa (eye worm)	hypothetical protein	0.1702	0.8724	0.9252
Schistosoma mansoni	titin	0.0109	0.0405	0.2446
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0135	0.0539	0.326
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0135	0.0539	0.326
Loa Loa (eye worm)	CAMK protein kinase	0.0109	0.0405	0.0429
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.01	0.0359	0.0359
Schistosoma mansoni	ephrin receptor	0.0109	0.0405	0.2446
Echinococcus granulosus	Fibronectin type III	0.0109	0.0405	0.2446
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0135	0.0539	0.326
Schistosoma mansoni	hypothetical protein	0.0069	0.0193	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus granulosus	contactin	0.0109	0.0405	0.2446
Echinococcus granulosus	G1Y162 protein	0.0109	0.0405	0.2446
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0244	0.111	0.6709
Schistosoma mansoni	nephrin	0.0109	0.0405	0.2446
Onchocerca volvulus		0.0135	0.0539	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Brugia malayi	Fibronectin type III domain containing protein	0.0109	0.0405	0.0405
Echinococcus multilocularis	roundabout 2	0.0109	0.0405	0.2446
Brugia malayi	Lethal protein 805	0.0109	0.0405	0.0405
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0135	0.0539	0.326
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0109	0.0405	0.0429
Onchocerca volvulus		0.0135	0.0539	0.0151
Brugia malayi	RNA, U transporter 1	0.0093	0.0319	0.0319
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0135	0.0539	0.326
Onchocerca volvulus		0.0135	0.0539	0.0151
Onchocerca volvulus		0.0135	0.0539	0.0151
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0135	0.0539	0.326
Schistosoma mansoni	pcd6 interacting protein-related	0.0135	0.0539	0.326
Onchocerca volvulus		0.0135	0.0539	0.0151
Schistosoma mansoni	cell adhesion molecule	0.0109	0.0405	0.2446
Echinococcus granulosus	roundabout 2	0.0109	0.0405	0.2446
Loa Loa (eye worm)	myotactin form A	0.0109	0.0405	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Echinococcus granulosus	anosmin 1	0.0109	0.0405	0.2446
Echinococcus granulosus	nephrin	0.0109	0.0405	0.2446
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0135	0.0539	0.326
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Onchocerca volvulus		0.0135	0.0539	0.0151
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0135	0.0539	0.326
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0405	0.0429
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0135	0.0539	0.0572
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0109	0.0405	0.2446
Brugia malayi	hypothetical protein	0.0135	0.0539	0.0539
Onchocerca volvulus		0.0135	0.0539	0.0151
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0045	0.027
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Onchocerca volvulus		0.0135	0.0539	0.0151
Echinococcus multilocularis	Netrin receptor DCC	0.0109	0.0405	0.2446
Schistosoma mansoni	titin	0.0109	0.0405	0.2446
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus granulosus	anosmin 1	0.0109	0.0405	0.2446
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0135	0.0539	0.326
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0135	0.0539	0.326
Brugia malayi	Calcitonin receptor-like protein seb-1	0.01	0.0359	0.0359
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0109	0.0405	0.0429
Schistosoma mansoni	neuroglian	0.0109	0.0405	0.2446
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0109	0.0405	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Brugia malayi	Fibronectin type III domain containing protein	0.0109	0.0405	0.0405
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0135	0.0539	1
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus multilocularis	anosmin 1	0.0109	0.0405	0.2446
Schistosoma mansoni	nephrin	0.0109	0.0405	0.2446
Brugia malayi	Protein-tyrosine phosphatase	0.0135	0.0539	0.0539
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0135	0.0539	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0135	0.0539	0.326
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0135	0.0539	0.0572
Loa Loa (eye worm)	hypothetical protein	0.0135	0.0539	0.0572
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0244	0.111	0.6709
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0109	0.0405	0.7481
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0244	0.111	0.6709
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0109	0.0405	0.0429
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Echinococcus granulosus	neuroglian	0.0109	0.0405	0.2446
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0135	0.0539	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0135	0.0539	0.0539
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0135	0.0539	0.326
Loa Loa (eye worm)	projectin	0.0109	0.0405	0.0429
Echinococcus multilocularis	hypothetical protein	0.0135	0.0539	0.326
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0109	0.0405	0.2446

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL3099528

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1818426