Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.003 | 0.003 | 0.0014 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.004 | 0.0045 | 0.0115 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0021 | 0.0016 | 0.004 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.003 | 0.003 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.6295 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0059 | 0.0076 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.6295 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.6295 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.6295 | 1 | 0.5 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.2458 | 0.3894 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.6295 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.004 | 0.0045 | 0.0045 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.2458 | 0.3894 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0021 | 0.0016 | 0.2066 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.003 | 0.0014 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.6295 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.6295 | 1 | 1 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.6295 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.6295 | 1 | 1 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.6295 | 1 | 1 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.6295 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.003 | 0.3888 |
Loa Loa (eye worm) | CYP4Cod1 | 0.003 | 0.003 | 0.3888 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2458 | 0.3894 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0021 | 0.0016 | 0.0016 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.003 | 0.003 | 0.0014 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.6295 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0021 | 0.0016 | 0.0016 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2458 | 0.3894 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.6295 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2458 | 0.3894 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.004 | 0.0045 | 0.5911 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0051 | 0.0051 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0051 | 0.0051 |
Brugia malayi | Cytochrome P450 family protein | 0.0021 | 0.0016 | 0.0016 |
Brugia malayi | Cytochrome P450 family protein | 0.003 | 0.003 | 0.003 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.2458 | 0.3894 | 0.3884 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0037 | 0.4812 |
Trypanosoma brucei | cytochrome P450, putative | 0.003 | 0.003 | 0.0014 |
Trypanosoma cruzi | cytochrome P450, putative | 0.003 | 0.003 | 0.0014 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2458 | 0.3894 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.003 | 0.003 | 0.3888 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.6295 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2458 | 0.3894 | 1 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.2458 | 0.3894 | 0.3894 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.2458 | 0.3894 | 1 |
Echinococcus multilocularis | 0.0021 | 0.0016 | 0.004 | |
Brugia malayi | cytochrome P450 | 0.0021 | 0.0016 | 0.0016 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.004 | 0.0045 | 0.0115 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2458 | 0.3894 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.2458 | 0.3894 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.2458 | 0.3894 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0059 | 0.0076 | 0.0076 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.