Detailed information for compound 1818852

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 516.757 | Formula: C34H48N2O2
  • H donors: 0 H acceptors: 0 LogP: 7.87 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 2
  • SMILES: C1CCC(=C(c2ccc(cc2)OCCN2CCCCCC2)c2ccc(cc2)OCCN2CCCCCC2)C1
  • InChi: 1S/C34H48N2O2/c1-2-8-22-35(21-7-1)25-27-37-32-17-13-30(14-18-32)34(29-11-5-6-12-29)31-15-19-33(20-16-31)38-28-26-36-23-9-3-4-10-24-36/h13-20H,1-12,21-28H2
  • InChiKey: SOBUOEXYMAJAHF-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 1 Starlite/ChEMBL References
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 2 Starlite/ChEMBL References
Homo sapiens proteasome (prosome, macropain) subunit, beta type, 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127834 All targets in OG5_127834
Brugia malayi proteasome subunit beta type 1 Get druggable targets OG5_127834 All targets in OG5_127834
Cryptosporidium parvum Pre2p/proteasome subunit beta type 5; NTN hydrolase fold Get druggable targets OG5_127100 All targets in OG5_127100
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127700 All targets in OG5_127700
Plasmodium falciparum proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium vivax proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium berghei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium hominis 20S proteasome beta subunit D2 (PBD2) Get druggable targets OG5_127700 All targets in OG5_127700
Plasmodium knowlesi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Brugia malayi proteasome subunit beta type 2 Get druggable targets OG5_127700 All targets in OG5_127700
Giardia lamblia Proteasome subunit beta type 1 Get druggable targets OG5_127834 All targets in OG5_127834
Echinococcus multilocularis proteasome (prosome, macropain) Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium knowlesi proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Cryptosporidium parvum 20S proteasome beta subunit D2 (PBD2) , putative Get druggable targets OG5_127700 All targets in OG5_127700
Trypanosoma brucei proteasome beta 6 subunit Get druggable targets OG5_127834 All targets in OG5_127834
Entamoeba histolytica probable proteasome subunit beta type 2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Echinococcus granulosus proteasome prosome macropain subunit beta Get druggable targets OG5_127700 All targets in OG5_127700
Leishmania mexicana proteasome beta 2 subunit, putative Get druggable targets OG5_127700 All targets in OG5_127700
Plasmodium vivax proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma japonicum ko:K02737 20S proteasome subunit beta 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Neospora caninum Family T1, proteasome beta subunit, threonine peptidase, related Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma congolense proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Loa Loa (eye worm) proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127700 All targets in OG5_127700
Trypanosoma brucei gambiense proteasome beta 6 subunit,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania donovani proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127834 All targets in OG5_127834
Loa Loa (eye worm) proteasome subunit beta type 1 Get druggable targets OG5_127834 All targets in OG5_127834
Echinococcus granulosus proteasome prosome macropain subunit beta Get druggable targets OG5_127834 All targets in OG5_127834
Mycobacterium ulcerans proteasome PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Brugia malayi Proteasome A-type and B-type family protein Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus granulosus proteasome prosome macropain Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma japonicum ko:K02734 20S proteasome subunit beta 4, putative Get druggable targets OG5_127700 All targets in OG5_127700
Trypanosoma congolense proteasome beta 6 subunit Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma cruzi proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Leishmania braziliensis proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Neospora caninum Proteasome (Prosome, macropain) subunit, beta type, 1, related Get druggable targets OG5_127700 All targets in OG5_127700
Schistosoma japonicum ko:K02732 20S proteasome subunit beta 6, putative Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium berghei proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Plasmodium vivax proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Plasmodium falciparum proteasome subunit beta type-5 Get druggable targets OG5_127100 All targets in OG5_127100
Giardia lamblia Proteasome subunit beta type 2 Get druggable targets OG5_127700 All targets in OG5_127700
Theileria parva proteasome beat subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Toxoplasma gondii proteasome subunit beta type, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi 20S proteasome subunit Get druggable targets OG5_127700 All targets in OG5_127700
Leishmania donovani proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Entamoeba histolytica proteasome subunit beta type 1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) Get druggable targets OG5_127100 All targets in OG5_127100
Plasmodium yoelii proteasome subunit beta type 1-related Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania major proteasome beta 2 subunit, putative Get druggable targets OG5_127700 All targets in OG5_127700
Mycobacterium leprae proteasome (beta subunit) PrcB Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma mansoni proteasome subunit beta 1 (T01 family) Get druggable targets OG5_127834 All targets in OG5_127834
Babesia bovis proteasome beta 2 subunit, putative Get druggable targets OG5_127700 All targets in OG5_127700
Toxoplasma gondii proteasome subunit beta type 2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Cryptosporidium hominis proteasome subunit beta type 1 (20S proteasome alpha subunit F) (20S proteasome subunit beta-6) Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania donovani proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Candida albicans endopeptidase required for mitosis and sporulation Get druggable targets OG5_127700 All targets in OG5_127700
Trypanosoma cruzi proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania braziliensis proteasome beta 2 subunit, putative Get druggable targets OG5_127700 All targets in OG5_127700
Babesia bovis proteasome A-type and B-type family protein Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium yoelii proteosome PSMB5/8 protein Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania mexicana proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium yoelii proteasome subunit beta type 2 Get druggable targets OG5_127700 All targets in OG5_127700
Giardia lamblia Proteasome subunit beta type 5 precursor Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans endopeptidase required for mitosis and sporulation Get druggable targets OG5_127700 All targets in OG5_127700
Babesia bovis proteasome epsilon subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Candida albicans proteasome subunit Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma cruzi proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania infantum proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta Get druggable targets OG5_127834 All targets in OG5_127834
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. Get druggable targets OG5_127100 All targets in OG5_127100
Schistosoma mansoni proteasome subunit beta 2 (T01 family) Get druggable targets OG5_127700 All targets in OG5_127700
Theileria parva proteasome subunit beta type 5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma brucei gambiense proteasome beta 2 subunit, putative,20S proteasome subunit Get druggable targets OG5_127700 All targets in OG5_127700
Plasmodium falciparum proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Plasmodium berghei proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania braziliensis proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta Get druggable targets OG5_127700 All targets in OG5_127700
Trypanosoma brucei gambiense proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative Get druggable targets OG5_127100 All targets in OG5_127100
Leishmania major proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma congolense proteasome subunit beta type-2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Leishmania infantum proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Schistosoma mansoni proteasome subunit beta 2 (T01 family) Get druggable targets OG5_127700 All targets in OG5_127700
Cryptosporidium parvum proteasome subunit beta type 1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Neospora caninum hypothetical protein Get druggable targets OG5_127834 All targets in OG5_127834
Trypanosoma brucei proteasome subunit beta type-5, putative Get druggable targets OG5_127100 All targets in OG5_127100
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase Get druggable targets OG5_127100 All targets in OG5_127100
Trypanosoma cruzi proteasome beta 6 subunit, putative Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania infantum proteasome beta 2 subunit, putative Get druggable targets OG5_127700 All targets in OG5_127700
Theileria parva proteasome subunit beta type 2, putative Get druggable targets OG5_127700 All targets in OG5_127700
Candida albicans proteasome subunit Get druggable targets OG5_127100 All targets in OG5_127100
Loa Loa (eye worm) proteasome subunit beta type 2 Get druggable targets OG5_127700 All targets in OG5_127700
Toxoplasma gondii proteasome subunit beta type 1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Plasmodium knowlesi proteasome subunit beta type-1, putative Get druggable targets OG5_127834 All targets in OG5_127834
Leishmania mexicana proteasome beta 5 subunit, putative Get druggable targets OG5_127100 All targets in OG5_127100

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum proteasome subunit beta type-5 proteasome (prosome, macropain) subunit, beta type, 1 241 aa 194 aa 27.3 %
Trypanosoma brucei proteasome alpha 3 subunit, putative proteasome (prosome, macropain) subunit, beta type, 2 176 aa 146 aa 26.0 %
Plasmodium falciparum proteasome subunit alpha type-5, putative proteasome (prosome, macropain) subunit, beta type, 5 160 aa 148 aa 23.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.1068 0.2471
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0019 0.0491 0.0491
Echinococcus multilocularis proteasome subunit alpha type 2 0.0019 0.0491 0.0491
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0032 0.1068 0.2471
Brugia malayi Tubulin alpha-2 chain 0.0032 0.1068 0.1068
Leishmania major epsilon tubulin, putative 0.0024 0.0698 0.1538
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0019 0.0491 0.1017
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Brugia malayi proteasome subunit beta type 3 0.0019 0.0491 0.0491
Toxoplasma gondii beta tubulin 0.0024 0.0698 0.1538
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis cyclins, putative 0.0043 0.1533 0.364
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0019 0.0491 0.1017
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.1579 0.3756
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0019 0.0491 0.0491
Echinococcus granulosus tubulin alpha 1C chain 0.0032 0.1068 0.1068
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0019 0.0491 0.0205
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.1579 0.3756
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0019 0.0491 0.0491
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0019 0.0491 0.0491
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0019 0.0491 0.1017
Brugia malayi Tubulin beta-1 chain 0.0024 0.0698 0.0698
Echinococcus granulosus tubulin alpha 3 chain 0.0032 0.1068 0.1068
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0019 0.0491 0.1017
Entamoeba histolytica tubulin gamma chain 0.0024 0.0698 0.0773
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0019 0.0491 0.1017
Echinococcus granulosus cyclins 0.0018 0.0417 0.0417
Schistosoma mansoni alpha tubulin 0.0032 0.1068 0.1068
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0048 0.0048
Trichomonas vaginalis tubulin epsilon chain, putative 0.0032 0.1068 0.2471
Echinococcus granulosus cyclins 0.0018 0.0417 0.0417
Schistosoma mansoni tyrosine kinase 0.001 0.0048 0.0048
Trichomonas vaginalis cyclin B, putative 0.0043 0.1533 0.364
Brugia malayi Raf kinase 0.0211 0.9065 0.9065
Giardia lamblia 20S proteasome alpha subunit 3 0.0019 0.0491 0.1017
Trypanosoma cruzi CYC2-like cyclin, putative 0.0043 0.1533 0.364
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Plasmodium falciparum protein kinase 5 0.0044 0.1579 0.3756
Trypanosoma brucei epsilon tubulin 0.0024 0.0698 0.1538
Echinococcus granulosus tubulin alpha 3 chain 0.0032 0.1068 0.1068
Entamoeba histolytica tubulin alpha-1 chain 0.0032 0.1068 0.179
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0019 0.0491 0.0205
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Trichomonas vaginalis tubulin beta chain, putative 0.0024 0.0698 0.1538
Trypanosoma cruzi cyclin, putative 0.0043 0.1533 0.364
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0011 0.0128 0.0128
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0018 0.0417 0.0417
Trypanosoma cruzi epsilon tubulin, putative 0.0024 0.0698 0.1538
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0077 0.3068 0.3068
Plasmodium falciparum alpha tubulin 2 0.0032 0.1068 0.2471
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.1579 0.1579
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Entamoeba histolytica tubulin family protein 0.0024 0.0698 0.0773
Trichomonas vaginalis tubulin gamma chain, putative 0.0024 0.0698 0.1538
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Schistosoma mansoni tubulin subunit beta 0.0024 0.0698 0.0698
Echinococcus granulosus cyclin B 0.0043 0.1533 0.1533
Toxoplasma gondii beta-1 tubulin, putative 0.0024 0.0698 0.1538
Toxoplasma gondii alpha-tubulin I, putative 0.0032 0.1068 0.2471
Brugia malayi Proteasome subunit alpha type 1 0.0019 0.0491 0.0491
Plasmodium vivax proteasome subunit beta type-7, putative 0.0019 0.0491 0.1017
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0019 0.0491 0.0491
Trichomonas vaginalis cyclins, putative 0.0018 0.0417 0.0829
Trypanosoma brucei epsilon tubulin 0.0024 0.0698 0.1538
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0048 0.0048
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0019 0.0491 0.0491
Trichomonas vaginalis tubulin beta chain, putative 0.0014 0.023 0.0358
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis cyclin D, putative 0.0018 0.0417 0.0829
Toxoplasma gondii alpha tubulin TUBA1 0.0032 0.1068 0.2471
Loa Loa (eye worm) PAS-3 protein 0.0019 0.0491 0.0491
Brugia malayi proteasome subunit beta type 1 0.0077 0.3068 0.3068
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0019 0.0491 0.0205
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0044 0.1579 0.3756
Echinococcus multilocularis tubulin alpha chain 0.0032 0.1068 0.1068
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0019 0.0491 0.0491
Leishmania major proteasome beta 2 subunit, putative 0.0048 0.1756 0.4202
Schistosoma mansoni alpha tubulin 0.0032 0.1068 0.1068
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Trypanosoma brucei proteasome beta 7 subunit 0.0019 0.0491 0.1017
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0019 0.0491 0.0491
Trypanosoma cruzi cdc2-related kinase 1 0.0044 0.1579 0.3756
Echinococcus granulosus proteasome subunit beta type 7 0.0019 0.0491 0.0491
Brugia malayi Proteasome A-type and B-type family protein 0.0099 0.4058 0.4058
Echinococcus multilocularis cyclins 0.0018 0.0417 0.0417
Trichomonas vaginalis cyclin B, putative 0.0043 0.1533 0.364
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0019 0.0491 0.1017
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Schistosoma mansoni serine/threonine protein kinase 0.0232 1 1
Schistosoma mansoni tubulin subunit gamma 0.0024 0.0698 0.0698
Trypanosoma brucei cdc2-related kinase 3 0.0044 0.1579 0.3756
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0019 0.0491 0.1017
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0019 0.0491 0.0205
Loa Loa (eye worm) proteasome subunit beta type 2 0.0048 0.1756 0.1756
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0077 0.3068 0.7506
Echinococcus granulosus cyclin B3 1 0.0018 0.0417 0.0417
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.1579 0.3756
Echinococcus granulosus Tubulin alpha 1 chain 0.0032 0.1068 0.1068
Trichomonas vaginalis tubulin epsilon chain, putative 0.0032 0.1068 0.2471
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0019 0.0491 0.1017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.3068 0.7506
Echinococcus granulosus subfamily T1A non peptidase ue 0.0019 0.0491 0.0491
Brugia malayi tubulin alpha-2 chain 0.0032 0.1068 0.1068
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0048 0.0048
Echinococcus granulosus proteasome subunit alpha type 2 0.0019 0.0491 0.0491
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0019 0.0491 0.0205
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0019 0.0491 0.1017
Trypanosoma brucei beta tubulin 0.0024 0.0698 0.1538
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.1068 0.2471
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0024 0.0698 0.1538
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0048 0.1756 0.4202
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0019 0.0491 0.0205
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0019 0.0491 0.0491
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0019 0.0491 0.1017
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0099 0.4058 1
Trypanosoma brucei alpha tubulin, putative 0.0014 0.023 0.0358
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0019 0.0491 0.0491
Echinococcus granulosus proteasome subunit alpha type 6 0.0019 0.0491 0.0491
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0019 0.0491 0.1017
Schistosoma mansoni tyrosine kinase 0.001 0.0048 0.0048
Trypanosoma brucei mitotic cyclin 6 0.0043 0.1533 0.364
Echinococcus multilocularis tubulin gamma 1 chain 0.0024 0.0698 0.0698
Echinococcus granulosus tubulin alpha chain 0.0032 0.1068 0.1068
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Leishmania major proteasome beta 5 subunit, putative 0.0099 0.4058 1
Entamoeba histolytica tubulin family protein 0.0024 0.0698 0.0773
Echinococcus granulosus Tubulin alpha 1 chain 0.0032 0.1068 0.1068
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0019 0.0491 0.0491
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0048 0.0048
Echinococcus multilocularis cyclins 0.0018 0.0417 0.0417
Trichomonas vaginalis cyclin D, putative 0.0018 0.0417 0.0829
Loa Loa (eye worm) alpha-tubulin 0.0032 0.1068 0.1068
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.023 0.0358
Echinococcus granulosus proteasome prosome macropain 0.0099 0.4058 0.4058
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0019 0.0491 0.1017
Schistosoma mansoni tubulin subunit alpha 0.001 0.0087 0.0087
Giardia lamblia Beta tubulin 0.0024 0.0698 0.1538
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0048 0.0048
Echinococcus granulosus cyclins 0.0018 0.0417 0.0417
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.1579 0.3756
Trypanosoma cruzi alpha tubulin, putative 0.0032 0.1068 0.2471
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0019 0.0491 0.0491
Giardia lamblia 20S proteasome alpha subunit 4 0.0019 0.0491 0.1017
Loa Loa (eye worm) hypothetical protein 0.0032 0.1068 0.1068
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.0099 0.4058 0.4058
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0099 0.4058 1
Echinococcus multilocularis cyclins 0.0018 0.0417 0.0417
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0048 0.0048
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.1579 0.1579
Loa Loa (eye worm) alpha-tubulin 0.0032 0.1068 0.1068
Loa Loa (eye worm) BEN-1 protein 0.0024 0.0698 0.0698
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0048 0.1756 0.1756
Loa Loa (eye worm) hypothetical protein 0.0043 0.1538 0.1538
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.0099 0.4058 1
Toxoplasma gondii proteasome subunit 0.0019 0.0491 0.1017
Loa Loa (eye worm) tubulin beta-2A chain 0.0024 0.0698 0.0698
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0698 0.0698
Plasmodium falciparum tubulin gamma chain 0.0024 0.0698 0.1538
Loa Loa (eye worm) SRC-1 0.001 0.0048 0.0048
Schistosoma mansoni alpha tubulin 0.0032 0.1068 0.1068
Loa Loa (eye worm) tubulin alpha-3 chain 0.0019 0.0458 0.0458
Toxoplasma gondii beta-tubulin, putative 0.0024 0.0698 0.1538
Trypanosoma cruzi 20S proteasome subunit 0.0048 0.1756 0.4202
Giardia lamblia Kinase, CMGC CDK 0.0044 0.1579 0.3756
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0019 0.0491 0.0491
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0019 0.0491 0.1017
Onchocerca volvulus Notchless protein homolog 0.0019 0.0491 0.2008
Echinococcus multilocularis cyclin dependent kinase 1 0.0044 0.1579 0.1579
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0048 0.0048
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0044 0.1579 0.1579
Brugia malayi proteasome subunit beta type 2 0.0048 0.1756 0.1756
Treponema pallidum cell division protein FtsZ 0.001 0.0087 0.5
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0019 0.0491 0.0491
Trypanosoma cruzi cyclin, putative 0.0043 0.1533 0.364
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Trichomonas vaginalis tubulin alpha chain, putative 0.0024 0.0698 0.1538
Echinococcus granulosus tubulin subunit beta 0.0024 0.0698 0.0698
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0022 0.06 0.06
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0019 0.0491 0.0491
Plasmodium vivax proteasome subunit beta type-4, putative 0.0019 0.0491 0.1017
Schistosoma mansoni tubulin subunit beta 0.0024 0.0698 0.0698
Plasmodium vivax proteasome subunit beta type-6, putative 0.0019 0.0491 0.1017
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0019 0.0491 0.0491
Echinococcus multilocularis cyclins 0.0018 0.0417 0.0417
Trichomonas vaginalis cyclins, putative 0.0043 0.1533 0.364
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0077 0.3068 0.7506
Schistosoma mansoni tubulin subunit beta 0.0024 0.0698 0.0698
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0019 0.0491 0.1017
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0232 1 1
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0019 0.0491 0.1017
Loa Loa (eye worm) tubulin beta-4 chain 0.0024 0.0698 0.0698
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0019 0.0491 0.0491
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0018 0.0417 0.0417
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0019 0.0491 0.0491
Trypanosoma brucei proteasome beta 6 subunit 0.0077 0.3068 0.7506
Echinococcus multilocularis tubulin beta 1 chain 0.0024 0.0698 0.0698
Echinococcus multilocularis proteasome subunit beta type 7 0.0019 0.0491 0.0491
Trypanosoma brucei alpha tubulin 0.0032 0.1068 0.2471
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.1533 0.1533
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0019 0.0491 0.0491
Brugia malayi alpha-tubulin 0.0032 0.1068 0.1068
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0019 0.0491 0.0491
Echinococcus granulosus Proteasome subunit alpha beta 0.0019 0.0491 0.0491
Echinococcus multilocularis hypothetical protein 0.0032 0.1068 0.1068
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0019 0.0491 0.1017
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Brugia malayi beta-tubulin, identical 0.0024 0.0698 0.0698
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0698 0.0698
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0048 0.1756 0.4202
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0698 0.0698
Brugia malayi tubulin alpha chain - mouse 0.0032 0.1068 0.1068
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0048 0.1756 0.4202
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0698 0.0698
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0019 0.0491 0.0491
Schistosoma mansoni tyrosine kinase 0.001 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0022 0.06 0.06
Giardia lamblia Kinase, CMGC CDK 0.0044 0.1579 0.3756
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0048 0.0048
Brugia malayi Tubulin beta chain 0.001 0.0087 0.0087
Plasmodium vivax proteasome subunit beta type-5, putative 0.0099 0.4058 1
Plasmodium vivax protein kinase Crk2 0.0044 0.1579 0.3756
Mycobacterium ulcerans proteasome PrcB 0.0099 0.4058 1
Plasmodium falciparum tubulin epsilon chain, putative 0.0024 0.0698 0.1538
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0417 0.0829
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0048 0.0048
Trypanosoma brucei alpha tubulin 0.0032 0.1068 0.2471
Loa Loa (eye worm) tubulin alpha-2 chain 0.0032 0.1068 0.1068
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.1068 0.2471
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0698 0.0698
Trichomonas vaginalis cyclin B, putative 0.0043 0.1533 0.364
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0019 0.0491 0.1017
Echinococcus granulosus raf serine:threonine protein kinase 0.0218 0.9405 0.9405
Echinococcus multilocularis Tubulin alpha 1 chain 0.0032 0.1068 0.1068
Leishmania major proteasome beta 3 subunit, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0048 0.0048
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0019 0.0491 0.1017
Loa Loa (eye worm) proteasome subunit beta type 3 0.0019 0.0491 0.0491
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0019 0.0491 0.1017
Trichomonas vaginalis tubulin gamma chain, putative 0.0024 0.0698 0.1538
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0044 0.1579 0.1579
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0019 0.0491 0.1017
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Entamoeba histolytica cyclin, putative 0.0043 0.1533 0.3065
Plasmodium falciparum proteasome subunit beta type-5 0.0099 0.4058 1
Leishmania major proteasome alpha 1 subunit, putative 0.0019 0.0491 0.1017
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0019 0.0491 0.1017
Giardia lamblia Proteasome subunit beta type 5 precursor 0.0099 0.4058 1
Loa Loa (eye worm) cyclin domain-containing protein 0.0018 0.0417 0.0417
Plasmodium vivax tubulin gamma chain, putative 0.0024 0.0698 0.1538
Echinococcus multilocularis proteasome subunit alpha type 6 0.0019 0.0491 0.0491
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0019 0.0491 0.0205
Plasmodium vivax proteasome subunit beta type-3, putative 0.0019 0.0491 0.1017
Echinococcus granulosus tubulin alpha 1C chain 0.0032 0.1068 0.1068
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0019 0.0491 0.1017
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Giardia lamblia Hypothetical protein 0.0018 0.0417 0.0829
Giardia lamblia Cyclin A 0.0018 0.0417 0.0829
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0019 0.0491 0.1017
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis N chimaerin 0.0011 0.0128 0.0128
Echinococcus granulosus cyclin dependent kinase 0.0044 0.1579 0.1579
Loa Loa (eye worm) tubulin alpha 2 0.0022 0.06 0.06
Echinococcus multilocularis cyclin b3 0.0018 0.0417 0.0417
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0698 0.0698
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0048 0.1756 0.3678
Loa Loa (eye worm) tubulin beta chain 0.0024 0.0698 0.0698
Plasmodium falciparum cyclin 0.0018 0.0417 0.0829
Leishmania major proteasome alpha 7 subunit, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis cyclins 0.0018 0.0417 0.0417
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0019 0.0491 0.1017
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0019 0.0491 0.1017
Brugia malayi Tubulin alpha chain 0.0032 0.1068 0.1068
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0019 0.0491 0.1017
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0019 0.0491 0.1017
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0019 0.0491 0.1017
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis peroxisome assembly protein 26 0.0032 0.1068 0.1068
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0019 0.0491 0.1017
Giardia lamblia Proteasome subunit beta type 1 0.0077 0.3068 0.7506
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0019 0.0458 0.0933
Loa Loa (eye worm) tubulin alpha 2 0.0022 0.06 0.06
Echinococcus granulosus tubulin subunit TubB 0.0032 0.1068 0.1068
Giardia lamblia Gamma tubulin 0.0024 0.0698 0.1538
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0019 0.0491 0.0491
Echinococcus granulosus proteasome subunit beta type 6 0.0019 0.0491 0.0491
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0019 0.0491 0.0491
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0019 0.0491 0.1017
Giardia lamblia Beta tubulin 0.0024 0.0698 0.1538
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0019 0.0491 0.1017
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0048 0.1756 0.1756
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0011 0.0128 0.0128
Plasmodium falciparum tubulin beta chain 0.0024 0.0698 0.1538
Echinococcus granulosus cyclin b3 0.0018 0.0417 0.0417
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0024 0.0698 0.0698
Loa Loa (eye worm) hypothetical protein 0.0043 0.1533 0.1533
Brugia malayi Proteasome subunit alpha type 7-1 0.0019 0.0491 0.0491
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0019 0.0491 0.1017
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0019 0.0491 0.1017
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0019 0.0491 0.1017
Echinococcus multilocularis tubulin alpha 3 chain 0.0032 0.1068 0.1068
Brugia malayi Variant SH3 domain containing protein 0.0011 0.0128 0.0128
Echinococcus multilocularis tubulin alpha 3 chain 0.0032 0.1068 0.1068
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0048 0.0048
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0019 0.0491 0.1017
Trypanosoma brucei proteasome alpha 7 subunit 0.0019 0.0491 0.1017
Toxoplasma gondii proteasome subunit alpha1, putative 0.0019 0.0491 0.1017
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0019 0.0491 0.1017
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0019 0.0491 0.0491
Schistosoma mansoni tubulin subunit alpha 0.0032 0.1068 0.1068
Toxoplasma gondii heat shock protein hslv, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis cyclin B3, putative 0.0018 0.0417 0.0829
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0048 0.0048
Brugia malayi Cyclin, N-terminal domain containing protein 0.0018 0.0417 0.0417
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0043 0.1533 0.364
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0019 0.0491 0.0205
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0011 0.0128 0.0128
Brugia malayi 20S proteasome alpha5 subunit 0.0019 0.0491 0.0491
Loa Loa (eye worm) proteasome subunit beta type 1 0.0077 0.3068 0.3068
Schistosoma mansoni tubulin subunit alpha 0.0032 0.1068 0.1068
Plasmodium vivax tubulin alpha chain, putative 0.0032 0.1068 0.2471
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0698 0.0698
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.1068 0.2471
Schistosoma mansoni cyclin B3 0.0018 0.0417 0.0417
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.009 0.009
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0019 0.0491 0.0491
Schistosoma mansoni cyclin B 0.0043 0.1533 0.1533
Loa Loa (eye worm) tubulin alpha chain 0.0032 0.1068 0.1068
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0019 0.0491 0.0491
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0019 0.0491 0.1017
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0019 0.0491 0.0491
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis proteasome (prosome, macropain) 0.0099 0.4058 0.4058
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0019 0.0491 0.0491
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0099 0.4058 0.4058
Brugia malayi RhoGAP domain containing protein 0.0011 0.0128 0.0128
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0048 0.1756 0.1756
Toxoplasma gondii hypothetical protein 0.0014 0.0224 0.0344
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0011 0.0128 0.0128
Toxoplasma gondii proteasome beta subunit 0.0019 0.0491 0.1017
Echinococcus granulosus tubulin beta 4A class IVa 0.0024 0.0698 0.0698
Plasmodium vivax proteasome subunit beta type-1, putative 0.0077 0.3068 0.7506
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0019 0.0491 0.1017
Plasmodium falciparum proteasome subunit beta type-4 0.0019 0.0491 0.1017
Echinococcus granulosus tubulin alpha chain 0.0032 0.1068 0.1068
Leishmania major proteasome alpha 2 subunit, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0019 0.0491 0.1017
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0077 0.3068 0.7506
Leishmania major proteasome alpha 1 subunit, putative 0.0019 0.0491 0.1017
Plasmodium falciparum alpha tubulin 1 0.0032 0.1068 0.2471
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0011 0.0128 0.0128
Trichomonas vaginalis cyclins, putative 0.0043 0.1533 0.364
Trichomonas vaginalis CMGC family protein kinase 0.0044 0.1579 0.3756
Trypanosoma brucei beta tubulin 0.0024 0.0698 0.1538
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0048 0.1756 0.4202
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0019 0.0491 0.1017
Brugia malayi Tubulin alpha chain 0.001 0.0087 0.0087
Giardia lamblia 20S proteasome alpha subunit 2 0.0019 0.0491 0.1017
Loa Loa (eye worm) tubulin gamma chain 0.0024 0.0698 0.0698
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0077 0.3068 0.3068
Trichomonas vaginalis tubulin, putative 0.0024 0.0698 0.1538
Echinococcus multilocularis cyclins 0.0018 0.0417 0.0417
Trypanosoma brucei epsilon tubulin 0.0024 0.0698 0.1538
Schistosoma mansoni tubulin subunit delta 0.001 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0025 0.0735 0.0735
Echinococcus multilocularis tubulin epsilon chain 0.0024 0.0698 0.0698
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0019 0.0491 0.1017
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0048 0.0048
Brugia malayi proteasome subunit alpha type 2 0.0019 0.0491 0.0491
Trichomonas vaginalis cyclins, putative 0.0043 0.1533 0.364
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0014 0.023 0.0358
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0048 0.0048
Loa Loa (eye worm) tubulin beta chain 0.001 0.0087 0.0087
Loa Loa (eye worm) raf kinase 0.0216 0.931 0.931
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0019 0.0491 0.1017
Onchocerca volvulus 0.0043 0.1533 1
Trypanosoma cruzi epsilon tubulin, putative 0.0024 0.0698 0.1538
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0019 0.0491 0.1017
Trypanosoma cruzi beta tubulin, putative 0.0024 0.0698 0.1538
Echinococcus multilocularis tubulin subunit beta 0.0024 0.0698 0.0698
Echinococcus granulosus beta tubulin 0.0024 0.0698 0.0698
Echinococcus granulosus Proteasome subunit alpha type 7 0.0019 0.0491 0.0491
Brugia malayi Protein kinase domain containing protein 0.0044 0.1579 0.1579
Brugia malayi Tubulin beta chain 0.0014 0.023 0.023
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0077 0.3068 0.3068
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0048 0.0048
Echinococcus granulosus tubulin gamma 1 chain 0.0024 0.0698 0.0698
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.1579 0.1579
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0048 0.0048
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0019 0.0491 0.0205
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0019 0.0491 0.1017
Echinococcus multilocularis proteasome subunit beta type 6 0.0019 0.0491 0.0491
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0019 0.0491 0.1017
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0019 0.0491 0.1017
Echinococcus granulosus c-Jun N-terminal kinases 0.0232 1 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0024 0.0698 0.1538
Schistosoma mansoni vav2 0.0011 0.0128 0.0128
Echinococcus multilocularis tubulin alpha chain 0.0032 0.1068 0.1068
Echinococcus granulosus peroxisome assembly protein 26 0.0032 0.1068 0.1068
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.1068 0.2471
Brugia malayi proteasome subunit alpha type 3 0.0019 0.0491 0.0491
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.023 0.0358
Echinococcus granulosus tubulin alpha chain 0.0032 0.1068 0.1068
Giardia lamblia 20S proteasome alpha subunit 5 0.0019 0.0491 0.1017
Schistosoma mansoni cyclins 0.0018 0.0417 0.0417
Echinococcus granulosus Tubulin alpha 1 chain 0.0032 0.1068 0.1068
Loa Loa (eye worm) hypothetical protein 0.0019 0.0458 0.0458
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0019 0.0491 0.1017
Brugia malayi cell division control protein 2 homolog 0.0044 0.1579 0.1579
Trypanosoma cruzi cdc2-related kinase 3 0.0044 0.1579 0.3756
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0019 0.0491 0.1017
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0048 0.0048
Schistosoma mansoni serine/threonine protein kinase 0.0218 0.9405 0.9405
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis cyclin B, putative 0.0043 0.1533 0.364
Loa Loa (eye worm) BEN-1 protein 0.0024 0.0698 0.0698
Brugia malayi proteasome subunit alpha type 6 0.0019 0.0491 0.0491
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0019 0.0491 0.0205
Trypanosoma brucei alpha tubulin 0.0032 0.1068 0.2471
Loa Loa (eye worm) tubulin alpha chain 0.0032 0.1068 0.1068
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0019 0.0491 0.1017
Loa Loa (eye worm) hypothetical protein 0.0043 0.1533 0.1533
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0019 0.0491 0.0491
Echinococcus multilocularis tubulin subunit TubB 0.0032 0.1068 0.1068
Brugia malayi proteasome subunit alpha type 1 0.0019 0.0491 0.0491
Trichomonas vaginalis tubulin alpha chain, putative 0.0024 0.0698 0.1538
Echinococcus multilocularis tubulin alpha chain 0.0032 0.1068 0.1068
Mycobacterium leprae proteasome (beta subunit) PrcB 0.0099 0.4058 1
Giardia lamblia 20S proteasome alpha subunit 7 0.0019 0.0491 0.1017
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Brugia malayi Cell division protein ftsZ 0.001 0.0087 0.0087
Echinococcus multilocularis beta tubulin 0.0024 0.0698 0.0698
Echinococcus granulosus tubulin delta chain 0.001 0.0087 0.0087
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0048 0.1756 0.4202
Echinococcus granulosus tubulin beta 1 chain 0.0024 0.0698 0.0698
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0019 0.0491 0.1017
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0044 0.1579 0.3756
Schistosoma mansoni tubulin subunit beta 0.0024 0.0698 0.0698
Echinococcus multilocularis cyclin dependent kinase 5 0.0044 0.1579 0.1579
Echinococcus granulosus tubulin alpha 0.0024 0.0698 0.0698
Trichomonas vaginalis tubulin alpha chain, putative 0.0014 0.023 0.0358
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0019 0.0491 0.1017
Echinococcus granulosus tubulin alpha chain 0.0032 0.1068 0.1068
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0698 0.0698
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.1068 0.2471
Giardia lamblia Proteasome subunit beta type 3 0.0019 0.0491 0.1017
Plasmodium vivax proteasome subunit beta type-2, putative 0.0048 0.1756 0.4202
Giardia lamblia Beta tubulin 0.0024 0.0698 0.1538
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0019 0.0491 0.0491
Giardia lamblia Alpha-tubulin 0.0032 0.1068 0.2471
Mycobacterium leprae probable proteasome (alpha subunit) PrcA 0.0019 0.0491 0.1017
Echinococcus multilocularis Tubulin alpha 1 chain 0.0032 0.1068 0.1068
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0019 0.0491 0.0491
Schistosoma mansoni tubulin subunit beta 0.001 0.0087 0.0087
Schistosoma mansoni tubulin subunit alpha 0.0032 0.1068 0.1068
Trichomonas vaginalis cyclin A, putative 0.0043 0.1533 0.364
Echinococcus granulosus cyclin dependent kinase 1 0.0044 0.1579 0.1579
Entamoeba histolytica tubulin alpha chain, putative 0.0032 0.1068 0.179
Loa Loa (eye worm) tubulin beta-1 chain 0.0024 0.0698 0.0698
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0019 0.0491 0.0491
Leishmania major proteasome alpha 3 subunit, putative 0.0019 0.0491 0.1017
Leishmania major proteasome beta-1 subunit, putative 0.0019 0.0491 0.1017
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0019 0.0491 1
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0048 0.1756 0.4202
Echinococcus multilocularis tubulin alpha 1C chain 0.0032 0.1068 0.1068
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0048 0.0048
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0077 0.3068 0.7281
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0019 0.0491 0.0205
Trichomonas vaginalis tubulin, putative 0.0014 0.023 0.0358
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0019 0.0491 0.0491
Brugia malayi Proteasome A-type and B-type family protein 0.0019 0.0491 0.0491
Echinococcus granulosus proteasome subunit beta t family 0.0019 0.0491 0.0491
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0019 0.0491 0.0205
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0019 0.0491 0.0205
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0232 1 1
Brugia malayi proteasome subunit alpha type 4 0.0019 0.0491 0.0491
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.1579 0.1579
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0019 0.0491 0.1017
Toxoplasma gondii peptidase, T1 family protein 0.0019 0.0491 0.1017
Echinococcus multilocularis cyclins 0.0018 0.0417 0.0417
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0048 0.0048
Echinococcus granulosus beta tubulin 0.0024 0.0698 0.0698
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.0099 0.4058 1
Leishmania major proteasome beta 2 subunit, putative 0.0019 0.0491 0.1017
Leishmania major proteasome alpha 7 subunit, putative 0.0019 0.0491 0.1017
Leishmania major gamma-tubulin 0.0024 0.0698 0.1538
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0048 0.0048
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0022 0.06 0.1291
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0048 0.1756 0.1756
Trichomonas vaginalis cyclins, putative 0.0029 0.0927 0.2115
Trypanosoma cruzi tubulin gamma chain 0.0024 0.0698 0.1538
Echinococcus multilocularis tubulin alpha chain 0.0032 0.1068 0.1068
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.0099 0.4058 1
Giardia lamblia 20S proteasome alpha subunit 6 0.0019 0.0491 0.1017
Echinococcus granulosus cyclin dependent kinase 5 0.0044 0.1579 0.1579
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0019 0.0491 0.0491
Schistosoma mansoni tubulin subunit beta 0.0024 0.0698 0.0698
Giardia lamblia G2/mitotic-specific cyclin B 0.0043 0.1533 0.364
Brugia malayi Proteasome A-type and B-type family protein 0.0019 0.0491 0.0491
Echinococcus multilocularis Tubulin beta 2C chain 0.0024 0.0698 0.0698
Schistosoma mansoni tubulin subunit epsilon 0.0024 0.0698 0.0698
Plasmodium vivax tubulin alpha chain, putative 0.0032 0.1068 0.2471
Trypanosoma brucei tubulin gamma chain 0.0024 0.0698 0.1538
Trypanosoma cruzi cyclin 6, putative 0.0043 0.1533 0.364
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0019 0.0491 0.0205
Plasmodium vivax tubulin beta chain, putative 0.0024 0.0698 0.1538
Trichomonas vaginalis tubulin gamma chain, putative 0.0024 0.0698 0.1538
Echinococcus multilocularis raf serine:threonine protein kinase 0.0218 0.9405 0.9405
Echinococcus multilocularis cyclin B3 1 0.0018 0.0417 0.0417
Mycobacterium ulcerans proteasome PrcA 0.0019 0.0491 0.1017
Brugia malayi Cyclin, N-terminal domain containing protein 0.0043 0.1533 0.1533
Trypanosoma brucei cdc2-related kinase 1 0.0044 0.1579 0.3756
Trichomonas vaginalis cyclin B, putative 0.0018 0.0417 0.0829
Trichomonas vaginalis tubulin, putative 0.0014 0.023 0.0358
Trypanosoma brucei beta tubulin 0.0024 0.0698 0.1538
Echinococcus granulosus tubulin epsilon chain 0.0024 0.0698 0.0698
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0019 0.0491 0.1017
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0124 0.5188 0.5188
Toxoplasma gondii proteasome subunit beta type, putative 0.0099 0.4058 1
Leishmania major cyclin 0.0043 0.1533 0.364
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0048 0.0048
Echinococcus multilocularis cyclin B 0.0043 0.1533 0.1533
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0019 0.0491 0.1017
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0019 0.0491 0.1017
Echinococcus multilocularis Tubulin alpha 1 chain 0.0032 0.1068 0.1068
Echinococcus multilocularis beta tubulin 0.0024 0.0698 0.0698
Echinococcus granulosus c src tyrosine kinase 0.001 0.0048 0.0048
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.002 0.0533 0.0318
Brugia malayi Proteasome A-type and B-type family protein 0.0019 0.0491 0.0491
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Trypanosoma brucei alpha tubulin 0.0032 0.1068 0.2471
Schistosoma mansoni tubulin subunit beta 0.0024 0.0698 0.0698
Echinococcus granulosus cyclins 0.0018 0.0417 0.0417
Schistosoma mansoni tyrosine kinase 0.001 0.0048 0.0048
Echinococcus granulosus alpha tubulin 0.0032 0.1068 0.1068
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0019 0.0491 0.1017
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.1579 0.3192
Trypanosoma brucei beta tubulin 0.0024 0.0698 0.1538
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0077 0.3068 0.7506
Leishmania major proteasome beta 7 subunit, putative 0.0019 0.0491 0.1017
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0019 0.0491 0.0205
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0019 0.0491 0.0491
Echinococcus granulosus tubulin alpha chain 0.0032 0.1068 0.1068
Trypanosoma brucei beta tubulin 0.0024 0.0698 0.1538
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0048 0.0048
Echinococcus multilocularis tubulin delta chain 0.001 0.0087 0.0087
Giardia lamblia 20S proteasome alpha subunit 1 0.0019 0.0491 0.1017
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0019 0.0491 0.1017
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0019 0.0491 0.1017
Giardia lamblia Proteasome subunit beta type 2 0.0048 0.1756 0.4202
Brugia malayi Tubulin gamma chain 0.0024 0.0698 0.0698
Echinococcus multilocularis cyclin dependent kinase 0.0044 0.1579 0.1579
Echinococcus multilocularis tubulin alpha chain 0.0032 0.1068 0.1068
Plasmodium vivax tubulin epsilon chain, putative 0.0024 0.0698 0.1538
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0044 0.1579 0.1579
Trypanosoma brucei proteasome subunit beta type-5, putative 0.0099 0.4058 1
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Brugia malayi SRC-1 0.001 0.0048 0.0048
Leishmania major beta tubulin 0.0024 0.0698 0.1538
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Entamoeba histolytica cell division protein kinase 2, putative 0.0044 0.1579 0.3192
Echinococcus multilocularis tubulin alpha 1C chain 0.0032 0.1068 0.1068
Brugia malayi Tubulin alpha-2 chain 0.0032 0.1068 0.1068
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0019 0.0491 0.1017
Echinococcus granulosus Tubulin beta 2C chain 0.0024 0.0698 0.0698
Echinococcus granulosus cyclins 0.0018 0.0417 0.0417
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0044 0.1579 0.3756
Echinococcus multilocularis tubulin alpha 0.0024 0.0698 0.0698
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0077 0.3068 0.7506
Echinococcus granulosus N chimaerin 0.0011 0.0128 0.0128
Toxoplasma gondii proteasome subunit alpha type, putative 0.0019 0.0491 0.1017
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0024 0.0684 0.0684
Trichomonas vaginalis tubulin epsilon chain, putative 0.0024 0.0698 0.1538
Giardia lamblia Alpha-tubulin 0.0032 0.1068 0.2471
Loa Loa (eye worm) beta-tubulin 0.0024 0.0698 0.0698
Leishmania major alpha tubulin 0.0032 0.1068 0.2471
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0019 0.0491 0.1017

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 26.2 uM Cytotoxicity against ER-negative HEK293 cells after 48 hrs by MTT assay ChEMBL. 24321833
IC50 (binding) = 1.11 uM Inhibition of trypsin-like activity of human 20S proteasome beta 2 subunit assessed as hydrolysis of Boc-LRR-AMC fluorogenic substrate measured for 1 hr by fluorometric analysis ChEMBL. 24321833
IC50 (binding) = 1.67 uM Inhibition of PGPH-like activity of human 20S proteasome beta 1 subunit assessed as hydrolysis of Z-LLE-AMC fluorogenic substrate measured for 1 hr by fluorometric analysis ChEMBL. 24321833
IC50 (binding) = 2.7 uM Inhibition of chymotrypsin-like activity of human 20S proteasome beta 5 subunit assessed as hydrolysis of succinyl-LLVY-AMC fluorogenic substrate measured for 1 hr by fluorometric analysis ChEMBL. 24321833

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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