Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.076 | 0.9961 | 0.9961 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0256 | 0.0814 |
Brugia malayi | MAP kinase sur-1 | 0.076 | 0.9961 | 1 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0256 | 0.0257 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0256 | 0.0257 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0256 | 0.0257 |
Onchocerca volvulus | 0.004 | 0.0256 | 0.5 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0256 | 0.0257 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0256 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0256 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0256 | 0.0257 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0256 | 0.0257 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0256 | 0.5 |
Brugia malayi | beta-lactamase | 0.004 | 0.0256 | 0.0257 |
Trichomonas vaginalis | CMGC family protein kinase | 0.076 | 0.9961 | 1 |
Onchocerca volvulus | 0.004 | 0.0256 | 0.5 | |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0256 | 0.0257 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.076 | 0.9961 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0256 | 0.0814 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0256 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.076 | 0.9961 | 1 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0256 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0256 | 0.0257 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0256 | 0.0814 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0763 | 1 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0256 | 0.0256 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0256 | 0.0814 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0256 | 0.0814 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.076 | 0.9961 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0256 | 0.0257 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0256 | 0.0257 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0256 | 0.0257 |
Trichomonas vaginalis | CMGC family protein kinase | 0.076 | 0.9961 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0256 | 0.0814 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0763 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.076 | 0.9961 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.076 | 0.9961 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0256 | 0.0814 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.076 | 0.9961 | 0.9961 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.076 | 0.9961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0256 | 0.0257 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0256 | 0.0814 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0256 | 0.0257 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.076 | 0.9961 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.076 | 0.9961 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0256 | 0.0257 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0256 | 0.0257 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0256 | 0.0257 |
Onchocerca volvulus | 0.004 | 0.0256 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0256 | 0.0257 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0256 | 0.0814 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0256 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0256 | 0.0257 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0254 | 0.3147 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.076 | 0.9961 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.076 | 0.9961 | 0.9961 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0256 | 0.0257 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0256 | 0.0257 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0256 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.076 | 0.9961 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0256 | 0.0256 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0256 | 0.0256 |
Schistosoma mansoni | serine/threonine protein kinase | 0.076 | 0.9961 | 0.9961 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.076 | 0.9961 | 0.9961 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0256 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0256 | 0.0257 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0256 | 0.0256 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0256 | 0.0814 |
Giardia lamblia | Kinase, CMGC MAPK | 0.076 | 0.9961 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.076 | 0.9961 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.076 | 0.9961 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0256 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 4 mm | Antimicrobial activity against Escherichia coli at 0.5 mg/ml by well plate method | ChEMBL. | 24321835 |
IZ (functional) | = 5 mm | Antimicrobial activity against Candida albicans at 0.5 mg/ml by well plate method | ChEMBL. | 24321835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.