Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.1448 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1448 | 1 | 1 |
Onchocerca volvulus | 0.0086 | 0.0131 | 0.5 | |
Giardia lamblia | Kinase, CMGC MAPK | 0.1448 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.1448 | 1 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0068 | 0 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.1448 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1448 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1448 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1448 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.1448 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1448 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.1448 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.1448 | 1 | 0.5 |
Onchocerca volvulus | 0.0086 | 0.0131 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.1448 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.1448 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.1448 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0068 | 0 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.1448 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.1448 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.1448 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.1448 | 1 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0086 | 0.0131 | 0.0131 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.1448 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of SCD1 in human HepG2 cells using radiolabeled stearic acid as substrate | ChEMBL. | 24370012 | |
IC50 (binding) | = 342 nM | Inhibition of SCD1 in mouse liver microsomes | ChEMBL. | 24370012 |
Inhibition (binding) | Inhibition of human delta-6 desaturase at 10 uM | ChEMBL. | 24370012 | |
Inhibition (binding) | Inhibition of human delta-5 desaturase at 10 uM | ChEMBL. | 24370012 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.