Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0144 | 0.0301 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0144 | 0.0301 | 0.0206 |
Echinococcus granulosus | acetylcholinesterase | 0.0615 | 0.271 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0615 | 0.271 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0144 | 0.0301 | 0.0779 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0144 | 0.0301 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0301 | 0.0779 |
Plasmodium vivax | hypothetical protein, conserved | 0.0144 | 0.0301 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0202 | 0.06 | 0.1923 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.271 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.204 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0144 | 0.0301 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0615 | 0.271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0301 | 0.0779 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0144 | 0.0301 | 1 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.1896 | 0.9265 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0301 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.271 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0144 | 0.0301 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.019 | 0.0538 | 0.1688 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0144 | 0.0301 | 0.0222 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.019 | 0.0538 | 0.1688 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0301 | 0.0779 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0126 | 0.0208 | 0.0425 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0202 | 0.06 | 0.1923 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0144 | 0.0301 | 0.0779 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0144 | 0.0301 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0144 | 0.0301 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0615 | 0.271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0301 | 0.0779 |
Mycobacterium ulcerans | dehydrogenase | 0.0144 | 0.0301 | 0.0206 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0144 | 0.0301 | 0.0779 |
Onchocerca volvulus | Telomerase reverse transcriptase homolog | 0.0311 | 0.1155 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0615 | 0.271 | 1 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0085 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0144 | 0.0301 | 0.0206 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0144 | 0.0301 | 0.0779 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0126 | 0.0208 | 0.0425 |
Schistosoma mansoni | amine oxidase | 0.0144 | 0.0301 | 0.0779 |
Brugia malayi | SWIRM domain containing protein | 0.0144 | 0.0301 | 0.0779 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0104 | 0.0097 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0144 | 0.0301 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0615 | 0.271 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0257 | 0.0879 | 0.2991 |
Brugia malayi | hypothetical protein | 0.0144 | 0.0301 | 0.0779 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0104 | 0.0097 | 0.5 |
Giardia lamblia | Telomerase catalytic subunit | 0.0085 | 0 | 0.5 |
Brugia malayi | Telomerase reverse transcriptase | 0.0226 | 0.0721 | 0.2387 |
Brugia malayi | Carboxylesterase family protein | 0.0615 | 0.271 | 1 |
Schistosoma mansoni | amine oxidase | 0.0144 | 0.0301 | 0.0779 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0615 | 0.271 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0144 | 0.0301 | 0.0206 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0177 | 0.0473 | 0.144 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0144 | 0.0301 | 0.0222 |
Leishmania major | UDP-galactopyranose mutase | 0.0144 | 0.0301 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0144 | 0.0301 | 0.0779 |
Echinococcus multilocularis | 0.0144 | 0.0301 | 0.0779 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0615 | 0.271 | 1 |
Onchocerca volvulus | 0.0144 | 0.0301 | 0.1925 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0615 | 0.271 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0144 | 0.0301 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0144 | 0.0301 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0126 | 0.0208 | 0.0425 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.0301 | 0.0779 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0144 | 0.0301 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0177 | 0.0473 | 0.144 |
Echinococcus granulosus | acetylcholinesterase | 0.0615 | 0.271 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0144 | 0.0301 | 0.0779 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0144 | 0.0301 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0144 | 0.0301 | 0.0779 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | In vitro antibacterial activity against E. coli EC14 | ChEMBL. | 8230112 |
MIC (functional) | = 0.03 ug ml-1 | In vitro antibacterial activity against Klebsiella X26 | ChEMBL. | 8230112 |
MIC (functional) | = 0.03 ug ml-1 | In vitro antibacterial activity against E. coli EC14 | ChEMBL. | 8230112 |
MIC (functional) | = 0.06 ug ml-1 | In vitro antibacterial activity against Streptococcus pneumoniae PARK | ChEMBL. | 8230112 |
MIC (functional) | = 0.125 ug ml-1 | In vitro antibacterial activity against Haemophilus influenza C.L | ChEMBL. | 8230112 |
MIC (functional) | = 0.125 ug ml-1 | In vitro antibacterial activity against Enterobacter aerogenes C32 | ChEMBL. | 8230112 |
MIC (functional) | = 8 ug ml-1 | In vitro antibacterial activity against Staphylococcus aureus X1.1 | ChEMBL. | 8230112 |
MIC (functional) | = 16 ug ml-1 | In vitro antibacterial activity against Staphylococcus epidermidis 222 | ChEMBL. | 8230112 |
MIC (functional) | = 128 ug ml-1 | In vitro antibacterial activity against Pseudomonas PS72 | ChEMBL. | 8230112 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.