Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 551 aa | 29.9 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Onchocerca volvulus | Cholinesterase | 574 aa | 578 aa | 25.3 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Onchocerca volvulus | Putative nuclear protein | Cholinesterase | 574 aa | 572 aa | 40.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholinesterase | 574 aa | 554 aa | 36.1 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alkaline phosphatase | 0.0167 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.9673 | 0.9558 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.9673 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.9673 | 0.5 |
Treponema pallidum | 5'-nucleotidase (ushA) | 0.0143 | 0.7728 | 0.5 |
Echinococcus multilocularis | intestinal type alkaline phosphatase 1 | 0.0167 | 1 | 1 |
Schistosoma mansoni | alkaline phosphatase | 0.0167 | 1 | 1 |
Echinococcus multilocularis | intestinal type alkaline phosphatase | 0.0167 | 1 | 1 |
Toxoplasma gondii | 5'-nucleotidase, C-terminal domain-containing protein | 0.0143 | 0.7728 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.9673 | 0.5 |
Echinococcus granulosus | alkaline phosphatase | 0.0167 | 1 | 1 |
Schistosoma mansoni | 23-cyclic-nucleotide 2-phosphodiesterase | 0.0143 | 0.7728 | 0.693 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.9673 | 0.5 |
Schistosoma mansoni | 23-cyclic-nucleotide 2-phosphodiesterase | 0.0142 | 0.769 | 0.6879 |
Echinococcus granulosus | alkaline phosphatase intestinal gene 2 | 0.0167 | 1 | 1 |
Echinococcus multilocularis | alkaline phosphatase, intestinal, gene 2 | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.9673 | 0.5 |
Echinococcus multilocularis | alkaline phosphatase | 0.0167 | 1 | 1 |
Echinococcus granulosus | intestinal type alkaline phosphatase 1 | 0.0167 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.9673 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.47 uM | Inhibition of Electrophorus electricus acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | ChEMBL. | 24369842 |
IC50 (binding) | = 1.74 uM | Inhibition of equine serum butyrylcholinesterase using S-butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured for 30 mins by Ellman's method | ChEMBL. | 24369842 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.