Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0478 | 0.2839 | 0.5074 |
Leishmania major | carboxylase, putative | 0.0478 | 0.2839 | 0.2839 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0478 | 0.2839 | 0.2839 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0478 | 0.2839 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0478 | 0.2839 | 0.2839 |
Echinococcus granulosus | geminin | 0.0171 | 0.0007 | 0.0007 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0719 | 0.5065 | 0.5065 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0478 | 0.2839 | 1 |
Trypanosoma brucei | unspecified product | 0.0314 | 0.1329 | 0.1329 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.1254 | 1 | 1 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0214 | 0.0405 | 0.5 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0478 | 0.2839 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0478 | 0.2839 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.1254 | 1 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0907 | 0.6803 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.024 | 0.0643 | 0.2266 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.1254 | 1 | 1 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0214 | 0.0405 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0719 | 0.5065 | 0.5065 |
Chlamydia trachomatis | biotin carboxylase | 0.0434 | 0.2433 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0478 | 0.2839 | 1 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0478 | 0.2839 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0007 | 0.0007 |
Echinococcus multilocularis | geminin | 0.0171 | 0.0007 | 0.0007 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.1254 | 1 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.1254 | 1 | 1 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0907 | 0.6803 | 0.5 |
Schistosoma mansoni | pyruvate carboxylase | 0.0478 | 0.2839 | 0.2839 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.1254 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0719 | 0.5065 | 0.5065 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.121 | 0.9595 | 0.5 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0478 | 0.2839 | 0.2839 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0776 | 0.5594 | 1 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0478 | 0.2839 | 0.2839 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0478 | 0.2839 | 0.5074 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.0007 | 0.0007 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0478 | 0.2839 | 0.2839 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0478 | 0.2839 | 0.2839 |
Toxoplasma gondii | pyruvate carboxylase | 0.0478 | 0.2839 | 0.2839 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0478 | 0.2839 | 1 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0478 | 0.2839 | 0.2839 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.121 | 0.9595 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0478 | 0.2839 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.