TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.433 | Formula: C20H27NO4
H donors: 4 H acceptors: 3 LogP: 3.18 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCC[C@@H](Cc1ccc(cc1)OC)NC[C@@H](c1cc(O)cc(c1)O)O
InChi: 1S/C20H27NO4/c1-3-4-16(9-14-5-7-19(25-2)8-6-14)21-13-20(24)15-10-17(22)12-18(23)11-15/h5-8,10-12,16,20-24H,3-4,9,13H2,1-2H3/t16-,20-/m0/s1
InChiKey: HOCMNYATHYZPNH-JXFKEZNVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	adrenoceptor beta 2, surface	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.2968	0.3076
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0223	0.2968	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0223	0.2968	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0223	0.2968	0.2968
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	insulin receptor	0.0223	0.2968	0.3076
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0223	0.2968	0.2968
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0223	0.2968	0.3076
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0223	0.2968	0.3076
Echinococcus multilocularis	tyrosine protein kinase csk	0.0223	0.2968	0.3076
Leishmania major	protein kinase, putative	0.0223	0.2968	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0223	0.2968	0.2968
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Onchocerca volvulus		0.0223	0.2968	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0223	0.2968	0.9497
Schistosoma mansoni	protein tyrosine kinase	0.0223	0.2968	0.9497
Schistosoma mansoni	hypothetical protein	0.0223	0.2968	0.9497
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Echinococcus multilocularis	integrin linked protein kinase	0.0223	0.2968	0.3076
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0223	0.2968	0.2968
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0223	0.2968	1
Trichomonas vaginalis	STE family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Schistosoma mansoni	serine/threonine protein kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0223	0.2968	0.3076
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0223	0.2968	0.5
Echinococcus granulosus	integrin linked protein kinase	0.0223	0.2968	0.2968
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0242	0.5
Trichomonas vaginalis	TK family protein kinase	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0223	0.2968	1
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Echinococcus granulosus	ephrin type A receptor 4 A	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0223	0.2968	0.2968
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0223	0.2968	0.3076
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0223	0.2968	0.2968
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0223	0.2968	0.3076
Loa Loa (eye worm)	TK/ALK protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0223	0.2968	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0223	0.2968	0.2968
Schistosoma mansoni	serine/threonine protein kinase	0.0223	0.2968	0.9497
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0223	0.2968	0.3076
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0223	0.2968	0.2968
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0223	0.2968	0.3076
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0223	0.2968	0.2968
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0223	0.2968	1
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Leishmania major	hypothetical protein, conserved	0.0223	0.2968	0.5
Brugia malayi	C-terminal src kinase protein 1	0.0223	0.2968	1
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Echinococcus granulosus	raf serine:threonine protein kinase	0.0223	0.2968	0.2968
Echinococcus multilocularis	c src tyrosine kinase	0.0223	0.2968	0.3076
Echinococcus granulosus	c src tyrosine kinase	0.0223	0.2968	0.2968
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Schistosoma mansoni	beta-catenin	0.0096	0.1075	0.3441
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0223	0.2968	0.3076
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Brugia malayi	SH2 domain containing protein	0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Echinococcus multilocularis	T cell transcription factor 4 long C terminal	0.0064	0.0602	0.0624
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0223	0.2968	0.3076
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FAK protein kinase	0.0223	0.2968	1
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Plasmodium vivax	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0223	0.2968	1
Entamoeba histolytica	receptor protein kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	activated cdc42 kinase 1	0.0223	0.2968	0.3076
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Plasmodium falciparum	protein kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	FL cytokine receptor	0.0223	0.2968	0.3076
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.2968	0.3076
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0223	0.2968	0.2968
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Echinococcus multilocularis	protein kinase	0.0223	0.2968	0.3076
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.2968	1
Entamoeba histolytica	tyrosin kinase, putative	0.0223	0.2968	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0223	0.2968	0.3076
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0242	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0223	0.2968	0.3076
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	tyrosin kinase, putative	0.0223	0.2968	0.5
Toxoplasma gondii	protein kinase	0.0223	0.2968	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0223	0.2968	0.3076
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0223	0.2968	0.3076
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0223	0.2968	0.2968
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1765	0.5947
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0223	0.2968	0.2968
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0242	0.0504
Echinococcus multilocularis	conserved hypothetical protein	0.0672	0.9646	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Brugia malayi	SH2 domain containing protein	0.0223	0.2968	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0223	0.2968	0.2968
Entamoeba histolytica	hypothetical protein, conserved	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	HMG box family protein	0.0064	0.0602	0.2027
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0223	0.2968	0.3076
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.2968	1
Trypanosoma cruzi	protein kinase, putative	0.0223	0.2968	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0223	0.2968	1
Brugia malayi	Raf kinase	0.0223	0.2968	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0223	0.2968	0.3076
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	serine/threonine kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0223	0.2968	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0223	0.2968	1
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0223	0.2968	0.2968
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Echinococcus granulosus	protein tyrosine kinase	0.0223	0.2968	0.2968
Trypanosoma brucei	protein kinase, putative	0.0223	0.2968	1
Brugia malayi	hypothetical protein	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus granulosus	epidermal growth factor receptor	0.0223	0.2968	0.2968
Echinococcus granulosus	beta catenin	0.0096	0.1075	0.1075
Echinococcus granulosus	pangolin	0.0064	0.0602	0.0602
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0223	0.2968	0.2968
Schistosoma mansoni	pangolin	0.0064	0.0602	0.1925
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0223	0.2968	0.2968
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0223	0.2968	0.2968
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0223	0.2968	0.2968
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0223	0.2968	0.3076
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Brugia malayi	polk-prov protein	0.003	0.0097	0.0326
Trypanosoma cruzi	protein kinase, putative	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Brugia malayi	ephrin receptor 1 precursor	0.0223	0.2968	1
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0223	0.2968	0.2968
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0223	0.2968	0.3076
Trichomonas vaginalis	CAMK family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0223	0.2968	1
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0223	0.2968	0.2968
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Echinococcus granulosus	T cell transcription factor 4 long C terminal	0.0064	0.0602	0.0602
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0223	0.2968	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0223	0.2968	0.9497
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0223	0.2968	0.3076
Echinococcus granulosus	hypothetical protein	0.0297	0.4071	0.4071
Plasmodium falciparum	protein kinase, putative	0.0223	0.2968	0.5
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0223	0.2968	0.2968
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0223	0.2968	1
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0223	0.2968	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0223	0.2968	0.2968
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0223	0.2968	0.3076
Echinococcus granulosus	epidermal growth factor receptor	0.0223	0.2968	0.2968
Entamoeba histolytica	serine/threonine kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0223	0.2968	0.3076
Brugia malayi	hypothetical protein	0.0223	0.2968	1
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0223	0.2968	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0223	0.2968	0.3076
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0223	0.2968	0.2968
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Echinococcus granulosus	insulin receptor	0.0223	0.2968	0.2968
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.2968	0.3076
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0242	0.025
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0223	0.2968	0.3076
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0223	0.2968	0.2968
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0223	0.2968	0.3076
Echinococcus multilocularis	protein tyrosine kinase	0.0223	0.2968	0.3076
Schistosoma mansoni	ephrin receptor	0.0223	0.2968	0.9497
Echinococcus multilocularis	tyrosine protein kinase csk	0.0223	0.2968	0.3076
Onchocerca volvulus	Tyrosine kinase homolog	0.0223	0.2968	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0223	0.2968	0.5
Brugia malayi	Guanylyl cyclase protein 23	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0223	0.2968	1
Brugia malayi	Armadillo/beta-catenin-like repeat family protein	0.0096	0.1075	0.3623
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0223	0.2968	0.5
Echinococcus multilocularis	serotonin receptor	0.0142	0.1765	0.1829
Brugia malayi	Receptor family ligand binding region containing protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Giardia lamblia	Kinase	0.0223	0.2968	0.5
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0097	0.0326
Echinococcus granulosus	tyrosine protein kinase csk	0.0223	0.2968	0.2968
Echinococcus granulosus	activated cdc42 kinase 1	0.0223	0.2968	0.2968
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Entamoeba histolytica	tyrosin kinase, putative	0.0223	0.2968	0.5
Loa Loa (eye worm)	SRC-1	0.0223	0.2968	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0223	0.2968	0.3076
Brugia malayi	Furin-like cysteine rich region family protein	0.0223	0.2968	1
Brugia malayi	protein-tyrosine kinase	0.0223	0.2968	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0223	0.2968	0.9497
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	tyrosine kinase	0.0223	0.2968	0.3076
Entamoeba histolytica	receptor protein kinase, putative	0.0223	0.2968	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Brugia malayi	SRC-1	0.0223	0.2968	1
Onchocerca volvulus	Cirhin homolog	0.0095	0.1066	0.3591
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0223	0.2968	0.3076
Echinococcus granulosus	tyrosine kinase	0.0223	0.2968	0.2968
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0223	0.2968	0.9497
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0223	0.2968	0.3076
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0223	0.2968	0.3076
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0223	0.2968	0.3076
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Onchocerca volvulus		0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0223	0.2968	1
Schistosoma mansoni	serine/threonine protein kinase	0.0223	0.2968	0.9497
Onchocerca volvulus		0.0223	0.2968	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Echinococcus multilocularis	tyrosine protein kinase	0.0223	0.2968	0.3076
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0223	0.2968	0.5
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Trypanosoma brucei	DNA polymerase IV, putative	0.0034	0.0146	0.0171
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0223	0.2968	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0223	0.2968	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Echinococcus multilocularis	protein kinase	0.0223	0.2968	0.3076
Onchocerca volvulus		0.0223	0.2968	1
Entamoeba histolytica	tyrosin kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	heat shock protein 70	0.0223	0.2968	0.3076
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Echinococcus multilocularis	activin receptor type	0.0223	0.2968	0.3076
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0223	0.2968	0.2968
Entamoeba histolytica	ankyrin repeat protein	0.0223	0.2968	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0223	0.2968	0.2968
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Echinococcus granulosus	tyrosine protein kinase csk	0.0223	0.2968	0.2968
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0223	0.2968	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0223	0.2968	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.2968	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0223	0.2968	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0242	0.0504
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0223	0.2968	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0223	0.2968	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0223	0.2968	1
Schistosoma mansoni	serine/threonine protein kinase	0.0223	0.2968	0.9497
Schistosoma mansoni	serine/threonine RGC	0.0223	0.2968	0.9497
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0242	0.0504
Loa Loa (eye worm)	serine/threonine protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0142	0.1765	0.5648
Schistosoma mansoni	tyrosine protein kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0223	0.2968	0.3076
Onchocerca volvulus		0.0223	0.2968	1
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Plasmodium falciparum	protein kinase, putative	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Leishmania major	protein kinase, putative	0.0223	0.2968	0.5
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Schistosoma mansoni	ephrin receptor	0.0223	0.2968	0.9497
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0223	0.2968	0.9497
Echinococcus granulosus	tyrosine protein kinase	0.0223	0.2968	0.2968
Echinococcus multilocularis	epidermal growth factor receptor	0.0223	0.2968	0.3076
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1765	0.5947
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0223	0.2968	0.2968
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Loa Loa (eye worm)	TK protein kinase	0.0223	0.2968	1
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine kinase	0.0223	0.2968	0.3076
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	hypothetical protein	0.0223	0.2968	0.5
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0223	0.2968	0.9497
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0223	0.2968	0.3076
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Echinococcus granulosus	tyrosine protein kinase Srms	0.0223	0.2968	0.2968
Plasmodium falciparum	tyrosine kinase-like protein	0.0223	0.2968	0.5
Echinococcus granulosus	activin receptor type	0.0223	0.2968	0.2968
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0223	0.2968	0.3076
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0223	0.2968	0.5
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	serotonin receptor	0.0142	0.1765	0.1829
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0223	0.2968	0.3076
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Giardia lamblia	Kinase, NEK	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Echinococcus multilocularis	protein pangolin J	0.0064	0.0602	0.0624
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0223	0.2968	0.3076
Giardia lamblia	Kinase, NEK	0.0223	0.2968	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0223	0.2968	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0223	0.2968	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0223	0.2968	0.3076
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0223	0.2968	0.3076
Echinococcus granulosus	protein kinase	0.0223	0.2968	0.2968
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0223	0.2968	0.3076
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Brugia malayi	integrin-linked kinase	0.0223	0.2968	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0223	0.2968	0.5
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	cysteine surface protein, putative	0.0223	0.2968	0.5
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Entamoeba histolytica	ankyrin repeat protein	0.0223	0.2968	0.5
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Echinococcus granulosus	dna polymerase kappa	0.004	0.0242	0.0242
Brugia malayi	HMG box family protein	0.0064	0.0602	0.2027
Schistosoma mansoni	protein kinase	0.0223	0.2968	0.9497
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0223	0.2968	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0223	0.2968	0.5
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0223	0.2968	0.2968
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0223	0.2968	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Brugia malayi	Tyrosine-protein kinase PR2	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Brugia malayi	Protein kinase domain containing protein	0.0223	0.2968	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0223	0.2968	1
Toxoplasma gondii	STE kinase	0.0223	0.2968	0.5
Loa Loa (eye worm)	TK/ACK protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	AGC family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Schistosoma mansoni	hypothetical protein	0.0234	0.3125	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0223	0.2968	0.3076
Loa Loa (eye worm)	TK/FER protein kinase	0.0223	0.2968	1
Onchocerca volvulus		0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Trypanosoma brucei	Pseudokinase, putative	0.0223	0.2968	1
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Entamoeba histolytica	protein kinase, putative	0.0223	0.2968	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0223	0.2968	0.2968
Toxoplasma gondii	protein kinase domain-containing protein	0.0223	0.2968	0.5
Echinococcus granulosus	receptor type guanylyl cyclase	0.0223	0.2968	0.2968
Echinococcus granulosus	tyrosine kinase	0.0223	0.2968	0.2968
Giardia lamblia	Protein 21.1	0.0223	0.2968	0.5
Trypanosoma brucei	unspecified product	0.0034	0.0146	0.0171
Echinococcus granulosus	tyrosine protein kinase shark	0.0223	0.2968	0.2968
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0223	0.2968	0.3076
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0223	0.2968	0.3076
Onchocerca volvulus		0.0223	0.2968	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0223	0.2968	0.2968
Echinococcus granulosus	biogenic amine 5HT receptor	0.0142	0.1765	0.1765
Entamoeba histolytica	protein kinase domain containing protein	0.0223	0.2968	0.5
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2968	1
Loa Loa (eye worm)	HMP-2 protein	0.0096	0.1075	0.3623
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0223	0.2968	0.9497
Echinococcus multilocularis	beta catenin	0.0096	0.1075	0.1115
Trichomonas vaginalis	TKL family protein kinase	0.0223	0.2968	1
Brugia malayi	hypothetical protein	0.0223	0.2968	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0223	0.2968	0.3076
Schistosoma mansoni	tyrosine kinase	0.0223	0.2968	0.9497
Echinococcus granulosus	tyrosine kinase	0.0223	0.2968	0.2968

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 197 %	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation relative to isoproterenol	ChEMBL.	24326276
EC50 (functional)	= 6100 nM	Agonist activity at human beta2 adrenergic receptor expressed in HEK293 cells assessed as stimulation of cAMP accumulation	ChEMBL.	24326276
Ki (binding)	= 5.324	Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis	ChEMBL.	24326276
Ki (binding)	= 4740 nM	Displacement of [3H]-(R,R')-methoxyfenoterol from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis	ChEMBL.	24326276
Ki (binding)	> 100000 nM	Displacement of [3H]-CGP-12177 from human beta2 adrenergic receptor expressed in HEK cells by liquid scintillation counting analysis	ChEMBL.	24326276

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3099664

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1819204