Detailed information for compound 1819292

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 429.35 | Formula: C22H25BrN2O2
  • H donors: 0 H acceptors: 1 LogP: 5.08 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)N(c1ccccc1)Cc1cccc(c1)Br
  • InChi: 1S/C22H25BrN2O2/c1-24-19-10-11-20(24)14-21(13-19)27-22(26)25(18-8-3-2-4-9-18)15-16-6-5-7-17(23)12-16/h2-9,12,19-21H,10-11,13-15H2,1H3/t19-,20+,21+
  • InChiKey: VCHGIYMMLJTVHQ-AERCQKQUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cholinergic receptor, muscarinic 1 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 3 Starlite/ChEMBL References
Homo sapiens cholinergic receptor, muscarinic 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133264 All targets in OG5_133264
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji domain containing protein 0.014 0.0471 0.0469
Trypanosoma cruzi CYC2-like cyclin, putative 0.0116 0.0369 1
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0068 0.1718
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0168 0.0591 0.0589
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0082 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0591 0.0589
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0283 0.1078 0.3906
Echinococcus granulosus cyclin B 0.0116 0.0369 0.0369
Schistosoma mansoni lipoxygenase 0.0114 0.0361 0.0359
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0679 0.2753 1
Trypanosoma brucei cdc2-related kinase 3 0.0043 0.0061 0.1538
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Echinococcus granulosus 7TM GPCR rhodopsin 0.0168 0.0591 0.0591
Echinococcus granulosus neuroendocrine convertase 2 0.0868 0.3553 0.3553
Brugia malayi Dopamine receptor protein 1 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.026 0.0979 0.3545
Echinococcus granulosus cyclin dependent kinase 1 0.0043 0.0061 0.0061
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0149 0.1173
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0031 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0061 0.0059
Toxoplasma gondii subtilisin SUB7 0.0057 0.0122 0.338
Echinococcus granulosus dnaJ subfamily B 0.0409 0.1611 0.1611
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Brugia malayi Cathepsin L-like precursor 0.0045 0.0068 0.0077
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0033 0.0018 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0135 0.0133
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0168 0.0591 0.0589
Echinococcus granulosus 7tm_1 domain containing protein 0.0168 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0116 0.0369 0.0425
Treponema pallidum fructose-bisphosphate aldolase 0.0319 0.123 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.0591 0.0589
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0033
Loa Loa (eye worm) hypothetical protein 0.0057 0.0122 0.0139
Echinococcus granulosus neuropeptide receptor A26 0.0168 0.0591 0.0591
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.2217 0.9264 0.9264
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0122 0.0425
Echinococcus granulosus neuropeptide FF receptor 2 0.207 0.8642 0.8642
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0045 0.0068 0.0066
Brugia malayi rRNA methyltransferase 0.003 0.0005 0.0004
Plasmodium vivax FtsJ-like methyltransferase, putative 0.003 0.0005 0.0094
Echinococcus granulosus hypothetical protein 0.0168 0.0591 0.0591
Onchocerca volvulus 0.0036 0.0031 0.033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0168 0.0591 0.0589
Brugia malayi Cathepsin L-like precursor 0.0045 0.0068 0.0077
Echinococcus granulosus dro:myosuppressin receptor 0.0168 0.0591 0.0591
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0057 0.0122 0.3205
Schistosoma mansoni alpha-1 adrenergic receptor 0.0168 0.0591 0.0589
Echinococcus granulosus tachykinin peptides receptor 99D 0.0168 0.0591 0.0591
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0116 0.0369 1
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0209 0.0765 0.0884
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0149 0.3939
Toxoplasma gondii subtilisin SUB4 0.0057 0.0122 0.338
Trypanosoma cruzi cyclin, putative 0.0116 0.0369 1
Brugia malayi Trypsin family protein 0.0033 0.0018 0.0019
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Loa Loa (eye worm) hypothetical protein 0.0668 0.2708 0.3132
Onchocerca volvulus 0.0045 0.0068 0.0754
Schistosoma mansoni neuropeptide F-like receptor 0.0168 0.0591 0.0589
Loa Loa (eye worm) ctsf protein 0.0045 0.0068 0.0077
Trypanosoma cruzi subtilisin peptidase 0.0057 0.0122 0.32
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0057 0.0122 0.1795
Brugia malayi beta-lactamase family protein 0.0036 0.0031 0.0033
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0018 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus multilocularis sex peptide receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0679 0.2753 0.2752
Trichomonas vaginalis hypothetical protein 0.026 0.0979 0.3545
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Brugia malayi jmjC domain containing protein 0.0099 0.0299 0.0345
Schistosoma mansoni neuropeptide receptor 0.0168 0.0591 0.0589
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0068 0.1718
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus granulosus cyclins 0.0048 0.0083 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0696
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0005 0.0001
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0043 0.0061 0.1671
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0033
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1206 0.4984 0.4983
Echinococcus granulosus cyclins 0.0048 0.0083 0.0083
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0057 0.0122 0.1989
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0019
Giardia lamblia Hypothetical protein 0.0048 0.0083 0.0579
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi Cyclin, N-terminal domain containing protein 0.0048 0.0083 0.0094
Toxoplasma gondii ribosomal RNA methyltransferase (FtsJ) family protein 0.003 0.0005 0.0094
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0168 0.0591 0.0589
Brugia malayi hypothetical protein 0.0036 0.003 0.0033
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0045 0.0068 0.1862
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0018 0.0017
Onchocerca volvulus 0.0168 0.0591 0.6719
Echinococcus granulosus g protein coupled receptor 0.0168 0.0591 0.0591
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0168 0.0591 0.6719
Entamoeba histolytica hypothetical protein 0.0036 0.003 0.0208
Loa Loa (eye worm) beta-lactamase 0.0036 0.0031 0.0033
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi Trypsin family protein 0.0033 0.0018 0.0019
Brugia malayi hypothetical protein 0.0236 0.0877 0.1013
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0068 0.0513
Echinococcus granulosus g-protein coupled receptor 0.0168 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0168 0.0591 0.0589
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0591 0.0589
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0168 0.0591 0.0682
Onchocerca volvulus 0.0033 0.0018 0.0189
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0045 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0168 0.0591 0.0682
Echinococcus granulosus g protein coupled receptor 0.0168 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus granulosus somatostatin receptor 0.0168 0.0591 0.0591
Onchocerca volvulus 0.0033 0.0018 0.0189
Onchocerca volvulus 0.0033 0.0018 0.0189
Brugia malayi Trypsin family protein 0.0209 0.0765 0.0884
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0341 0.1322 0.4791
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.0591 0.0591
Trichomonas vaginalis cyclins, putative 0.0116 0.0369 0.1326
Echinococcus multilocularis dro:myosuppressin receptor 0.0168 0.0591 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0168 0.0591 0.0591
Echinococcus granulosus transmembrane protease serine 3 0.0033 0.0018 0.0018
Onchocerca volvulus 0.0168 0.0591 0.6719
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.0061 0.0458
Schistosoma mansoni biogenic amine receptor 0.0168 0.0591 0.0589
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0209 0.0765 0.0764
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.0539 0.6204
Schistosoma mansoni microtubule-associated protein tau 0.142 0.5891 0.5891
Brugia malayi larval opioid receptor 0.0168 0.0591 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0019
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0383 0.0441
Schistosoma mansoni hypothetical protein 0.0168 0.0591 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.085 1
Brugia malayi proprotein convertase 2 0.0868 0.3553 0.411
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Echinococcus multilocularis cyclin b3 0.0048 0.0083 0.0081
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0068 0.0165 0.0189
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0043 0.0061 0.0069
Loa Loa (eye worm) hypothetical protein 0.0116 0.0369 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0005 0.0003
Schistosoma mansoni hypothetical protein 0.0048 0.0082 0.0081
Brugia malayi Kringle domain containing protein 0.0113 0.0357 0.0411
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Entamoeba histolytica cyclin family protein 0.0048 0.0083 0.0638
Loa Loa (eye worm) fibroinase 0.0045 0.0068 0.0077
Loa Loa (eye worm) subtilase 0.0057 0.0122 0.0139
Echinococcus granulosus cyclins 0.0048 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.123 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0005 0.0083
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0048 0.0083 0.0083
Echinococcus granulosus glycoprotein Antigen 5 0.0033 0.0018 0.0018
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0035 0.0033
Trichomonas vaginalis cyclins, putative 0.0048 0.0083 0.0284
Onchocerca volvulus 0.0036 0.0031 0.033
Giardia lamblia FtsJ cell division protein, putative 0.003 0.0005 0.0024
Toxoplasma gondii subtilisin SUB1 0.0057 0.0122 0.338
Brugia malayi endoprotease bli-4 precursor 0.1206 0.4984 0.5766
Echinococcus granulosus cyclin dependent kinase 0.0043 0.0061 0.0061
Schistosoma mansoni adenoreceptor 0.0168 0.0591 0.0589
Loa Loa (eye worm) jmjC domain-containing protein 0.0099 0.0299 0.0345
Brugia malayi Protein kinase domain containing protein 0.0043 0.0061 0.0069
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0018 0.0017
Echinococcus granulosus neuropeptide receptor 0.0168 0.0591 0.0591
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Trichomonas vaginalis cyclin B, putative 0.0116 0.0369 0.1326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Echinococcus multilocularis neuropeptide receptor 0.0168 0.0591 0.0589
Plasmodium vivax subtilisin-like protease 1 0.0057 0.0122 0.338
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0877 0.0875
Echinococcus granulosus tm gpcr rhodopsin 0.2217 0.9264 0.9264
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0031 0.0033
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0057 0.0122 0.1113
Echinococcus multilocularis cyclin B3 1 0.0048 0.0083 0.0081
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.003 0.003
Echinococcus multilocularis cyclins 0.0048 0.0083 0.0081
Brugia malayi G protein-coupled receptor 0.0168 0.0591 0.0682
Echinococcus multilocularis ribosomal RNA large subunit methyltransferase 0.003 0.0005 0.0003
Echinococcus granulosus G protein coupled receptor 139 0.0168 0.0591 0.0591
Echinococcus granulosus Mastin 0.0033 0.0018 0.0018
Echinococcus multilocularis neuropeptide FF receptor 2 0.207 0.8642 0.8642
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0089 0.0101
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0679 0.2753 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0045 0.0068 0.1862
Loa Loa (eye worm) hypothetical protein 0.0045 0.0068 0.0077
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0168 0.0591 0.0589
Giardia lamblia Kinase, CMGC CDK 0.0043 0.0061 0.0422
Schistosoma mansoni cell division protein ftsj 0.003 0.0005 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Loa Loa (eye worm) TYRA-2 protein 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0168 0.0591 0.0589
Brugia malayi putative neuropeptide receptor 0.0168 0.0591 0.0682
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.003 0.0029
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0057 0.0122 0.0139
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0808 0.3301 0.33
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Brugia malayi G protein-coupled receptor F59B2.13 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Onchocerca volvulus 0.0168 0.0591 0.6719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Onchocerca volvulus 0.003 0.0005 0.0041
Giardia lamblia G2/mitotic-specific cyclin B 0.0116 0.0369 0.2611
Echinococcus granulosus g protein coupled receptor 0.0168 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0034 0.0022 0.0024
Trypanosoma cruzi cyclin 6, putative 0.0116 0.0369 1
Schistosoma mansoni neuropeptide F-like receptor 0.0168 0.0591 0.0589
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.0061 0.1532
Loa Loa (eye worm) hypothetical protein 0.0067 0.0162 0.0186
Schistosoma mansoni hypothetical protein 0.0033 0.0018 0.0017
Echinococcus multilocularis membrane bound transcription factor site 1 0.0057 0.0122 0.012
Onchocerca volvulus 0.0236 0.0878 1
Loa Loa (eye worm) cysteine protease 0.0045 0.0068 0.0077
Schistosoma mansoni neuropeptide receptor 0.239 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Echinococcus multilocularis tissue type plasminogen activator 0.0113 0.0357 0.0355
Brugia malayi Papain family cysteine protease containing protein 0.0045 0.0068 0.0077
Onchocerca volvulus 0.0045 0.0068 0.0754
Brugia malayi Cyclin, N-terminal domain containing protein 0.0116 0.0369 0.0425
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Mycobacterium leprae Possible secreted protease 0.0057 0.0122 0.1795
Loa Loa (eye worm) ribosomal RNA methyltransferase 0.003 0.0005 0.0004
Echinococcus granulosus allatostatin A receptor 0.0168 0.0591 0.0591
Echinococcus multilocularis neuropeptides capa receptor 0.0168 0.0591 0.0589
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0341 0.1322 0.4791
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0168 0.0591 0.0682
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0045 0.0068 0.0077
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0035 0.0035
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0168 0.0591 0.0589
Onchocerca volvulus Neuropeptide F receptor homolog 0.0168 0.0591 0.6719
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0168 0.0591 0.0589
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0114 0.0361 0.0361
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0168 0.0591 0.0591
Loa Loa (eye worm) proprotein convertase 2 0.0341 0.1322 0.1527
Echinococcus granulosus furin 0.1206 0.4984 0.4984
Loa Loa (eye worm) hypothetical protein 0.207 0.8642 1
Onchocerca volvulus 0.0209 0.0765 0.8708
Schistosoma mansoni histamine h1 receptor 0.0168 0.0591 0.0589
Schistosoma mansoni serine/threonine protein kinase 0.0043 0.0061 0.0059
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0878 0.3179
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Echinococcus granulosus putative ribosomal RNA methyltransferase/cell division FtsJ protein 0.003 0.0005 0.0005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0341 0.1322 0.4791
Echinococcus multilocularis orexin receptor type 2 0.0168 0.0591 0.0589
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0168 0.0591 0.0591
Entamoeba histolytica hypothetical protein 0.0036 0.003 0.0208
Schistosoma mansoni hypothetical protein 0.026 0.0979 0.0978
Echinococcus multilocularis Mastin 0.0033 0.0018 0.0017
Onchocerca volvulus 0.0168 0.0591 0.6719
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0591 0.0591
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Trichomonas vaginalis cyclin B, putative 0.0116 0.0369 0.1326
Brugia malayi Serotonin receptor 0.0168 0.0591 0.0682
Loa Loa (eye worm) neuropeptide F receptor 0.0168 0.0591 0.0682
Echinococcus multilocularis cyclins 0.0048 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0591 0.0591
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0168 0.0591 0.0589
Schistosoma mansoni biogenic amine receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis cathepsin L cysteine protease 0.0045 0.0068 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0031 0.0696
Schistosoma mansoni neuropeptide f receptor 76f 0.0168 0.0591 0.0589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Echinococcus multilocularis cyclin B 0.0116 0.0369 0.0368
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.0539 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0168 0.0591 0.0682
Brugia malayi neuroendocrine convertase 1 precursor 0.1016 0.4181 0.4837
Brugia malayi Cathepsin L-like precursor 0.003 0.0005 0.0004
Plasmodium falciparum subtilisin-like protease 3 0.0057 0.0122 0.338
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0591 0.0589
Schistosoma mansoni hypothetical protein 0.0036 0.003 0.0029
Loa Loa (eye worm) hypothetical protein 0.1206 0.4984 0.5766
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Echinococcus multilocularis cyclins 0.0048 0.0083 0.0081
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0341 0.1322 0.4791
Onchocerca volvulus 0.0168 0.0591 0.6719
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0033 0.0018 0.0017
Brugia malayi Pre-SET motif family protein 0.003 0.0005 0.0003
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0061 0.0204
Plasmodium vivax protein kinase Crk2 0.0043 0.0061 0.1671
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0149 0.0149
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0168 0.0591 0.0682
Echinococcus granulosus cyclin b3 0.0048 0.0083 0.0083
Trypanosoma brucei cdc2-related kinase 1 0.0043 0.0061 0.1538
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0149 0.0147
Loa Loa (eye worm) endoprotease bli-4 0.1206 0.4984 0.5766
Echinococcus granulosus neuropeptides capa receptor 0.0168 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi Cyclin, N-terminal domain containing protein 0.0116 0.0369 0.0425
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0591 0.0591
Onchocerca volvulus 0.0168 0.0591 0.6719
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0168 0.0591 0.0682
Plasmodium falciparum subtilisin-like protease 1 0.0057 0.0122 0.338
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0135 0.2242
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0045 0.0068 0.0229
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Echinococcus multilocularis neuropeptide receptor 0.239 1 1
Trichomonas vaginalis cyclin A, putative 0.0116 0.0369 0.1326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Entamoeba histolytica cell division protein kinase 2, putative 0.0043 0.0061 0.0458
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Onchocerca volvulus 0.0113 0.0357 0.4052
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0031 0.0814
Trichomonas vaginalis cyclin B, putative 0.0116 0.0369 0.1326
Brugia malayi Cathepsin L-like precursor 0.0045 0.0068 0.0077
Echinococcus multilocularis cyclins 0.0048 0.0083 0.0081
Brugia malayi ribosomal RNA methyltransferase 0.003 0.0005 0.0004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0005 0.0001
Leishmania major cysteine peptidase A (CPA) 0.0045 0.0068 0.1099
Toxoplasma gondii kringle domain-containing protein 0.0113 0.0357 1
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Echinococcus granulosus neuropeptide s receptor 0.0168 0.0591 0.0591
Onchocerca volvulus 0.0176 0.0626 0.7115
Brugia malayi Pre-SET motif family protein 0.0207 0.0757 0.0874
Echinococcus multilocularis transmembrane protease serine 3 0.0033 0.0018 0.0017
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0168 0.0591 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0122 0.0425
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0591 0.0591
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0057 0.0122 0.32
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0341 0.1322 0.132
Echinococcus multilocularis cysteine protease 0.0045 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.055 0.2209 0.2555
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0149 0.3939
Trichomonas vaginalis cyclins, putative 0.0116 0.0369 0.1326
Leishmania major hypothetical protein, conserved 0.0113 0.0357 0.9637
Schistosoma mansoni ribosomal RNA methyltransferase 0.003 0.0005 0.0003
Echinococcus granulosus cathepsin l1 0.0045 0.0068 0.0068
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0159 0.0554 0.0552
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0018 0.0017
Trypanosoma brucei mitotic cyclin 6 0.0116 0.0369 1
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.0061 0.0059
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0114 0.0361 0.0359
Mycobacterium ulcerans hypothetical protein 0.0036 0.0031 0.0237
Echinococcus multilocularis g-protein coupled receptor 0.0168 0.0591 0.0589
Brugia malayi RE15519p 0.0168 0.0591 0.0682
Onchocerca volvulus 0.0045 0.0068 0.0754
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.0093
Plasmodium falciparum cyclin 0.0048 0.0083 0.2293
Schistosoma mansoni hypothetical protein 0.0034 0.0022 0.0021
Onchocerca volvulus 0.0045 0.0068 0.0754
Trichomonas vaginalis cyclin B, putative 0.0048 0.0083 0.0284
Entamoeba histolytica cyclin family protein 0.0048 0.0083 0.0638
Echinococcus multilocularis cyclin dependent kinase 5 0.0043 0.0061 0.0059
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0168 0.0591 0.0591
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0005 0.0003
Brugia malayi GnHR receptor homolog 0.0168 0.0591 0.0682
Echinococcus granulosus cyclins 0.0048 0.0083 0.0083
Echinococcus granulosus neuropeptide Y receptor 0.0168 0.0591 0.0591
Trichomonas vaginalis cyclin B3, putative 0.0048 0.0083 0.0284
Onchocerca volvulus 0.0168 0.0591 0.6719
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.0357 0.9662
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0168 0.0591 0.0589
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.0539 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0033 0.0018 0.0019
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi Cathepsin L-like precursor 0.0045 0.0068 0.0077
Brugia malayi beta-lactamase 0.0036 0.0031 0.0033
Schistosoma mansoni opsin-like receptor 0.0168 0.0591 0.0589
Schistosoma mansoni cyclins 0.0048 0.0083 0.0081
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0004
Echinococcus granulosus Furin 1 0.0341 0.1322 0.1322
Echinococcus granulosus epidermal growth factor receptor 0.0123 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0004
Echinococcus granulosus cathepsin L cysteine proteinase 0.0045 0.0068 0.0068
Brugia malayi celfurPC protein 0.0946 0.3884 0.4493
Loa Loa (eye worm) hypothetical protein 0.0043 0.0059 0.0066
Echinococcus multilocularis neuropeptide Y receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis fmrfamide receptor 0.0168 0.0591 0.0589
Plasmodium vivax vivapain-2 0.0045 0.0068 0.1862
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0057 0.0122 0.32
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0068 0.0066
Echinococcus granulosus tm gpcr rhodopsin 0.0168 0.0591 0.0591
Echinococcus multilocularis cyclins 0.0048 0.0083 0.0081
Onchocerca volvulus 0.0045 0.0068 0.0754
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0068 0.0754
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.0093
Plasmodium falciparum large subunit rRNA methyltransferase, putative 0.003 0.0005 0.0094
Brugia malayi follicle stimulating hormone receptor 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0168 0.0591 0.0589
Toxoplasma gondii subtilisin SUB11 0.0057 0.0122 0.338
Brugia malayi Cathepsin L-like precursor 0.0045 0.0068 0.0077
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0031 0.0031
Echinococcus multilocularis microtubule associated protein 2 0.142 0.5891 0.5891
Echinococcus multilocularis neuropeptide Y receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0168 0.0591 0.0589
Brugia malayi Furin-like cysteine rich region family protein 0.0123 0.04 0.046
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0122 0.0425
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0005 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0081 0.0221 0.0786
Schistosoma mansoni survival motor neuron protein 0.0048 0.0082 0.0081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0135 0.0135
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0048 0.0083 0.0081
Entamoeba histolytica hypothetical protein 0.0036 0.003 0.0208
Brugia malayi MH2 domain containing protein 0.0119 0.0383 0.0441
Trichomonas vaginalis cyclins, putative 0.0116 0.0369 0.1326
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0168 0.0591 0.0591
Schistosoma mansoni amine GPCR 0.0168 0.0591 0.0589
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0031 0.0029
Echinococcus multilocularis neuropeptide receptor A26 0.0168 0.0591 0.0589
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Brugia malayi neuropeptide F receptor 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Leishmania major cyclin 0.0116 0.0369 1
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Trypanosoma cruzi cdc2-related kinase 1 0.0043 0.0061 0.1532
Plasmodium vivax subtilisin-like protease 2, putative 0.0057 0.0122 0.338
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0005 0.0004
Brugia malayi Cathepsin L-like cysteine proteinase 0.003 0.0005 0.0004
Schistosoma mansoni neuropeptide receptor 0.0168 0.0591 0.0589
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.123 1
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0033 0.0018 0.0017
Echinococcus multilocularis allatostatin A receptor 0.0168 0.0591 0.0589
Schistosoma mansoni amine GPCR 0.0168 0.0591 0.0589
Entamoeba histolytica cyclin, putative 0.0048 0.0083 0.0638
Onchocerca volvulus 0.0057 0.0122 0.137
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0341 0.1322 0.4791
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0168 0.0591 0.0589
Echinococcus multilocularis lysine specific demethylase 5A 0.0099 0.0299 0.0298
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0061 0.0069
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0679 0.2753 0.2753
Brugia malayi Melatonin receptor type 1A 0.0168 0.0591 0.0682
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0031 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Onchocerca volvulus 0.0045 0.0068 0.0754
Schistosoma mansoni biogenic amine receptor 0.0168 0.0591 0.0589
Toxoplasma gondii subtilisin SUB2 0.0057 0.0122 0.338
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0877 0.0877
Trichomonas vaginalis esterase, putative 0.0036 0.0031 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Toxoplasma gondii subtilisin SUB6 0.0057 0.0122 0.338
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0149 0.017
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0057 0.0122 0.1113
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0299 0.0298
Echinococcus multilocularis epidermal growth factor receptor 0.0123 0.04 0.0398
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Leishmania major subtilisin-like serine peptidase 0.0057 0.0122 0.2692
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0135 0.0133
Entamoeba histolytica cysteine protease, putative 0.0045 0.0068 0.0513
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0122 0.0425
Echinococcus granulosus enteropeptidase 0.0033 0.0018 0.0018
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0135 0.308
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0591 0.0589
Echinococcus granulosus biogenic amine 5HT receptor 0.0168 0.0591 0.0591
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0005 0.0003
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Echinococcus multilocularis neuropeptide s receptor 0.0168 0.0591 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Echinococcus granulosus jumonji domain containing protein 0.004 0.005 0.005
Trypanosoma cruzi cyclin, putative 0.0116 0.0369 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Brugia malayi G-protein coupled receptor 0.0168 0.0591 0.0682
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0168 0.0591 0.0589
Plasmodium falciparum subtilisin-like protease 2 0.0057 0.0122 0.338
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0209 0.0765 0.0764
Echinococcus multilocularis g protein coupled receptor 0.0168 0.0591 0.0589
Brugia malayi Protein kinase domain containing protein 0.0113 0.0357 0.0411
Schistosoma mansoni jumonji/arid domain-containing protein 0.0099 0.0299 0.0298
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0031 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Onchocerca volvulus 0.0168 0.0591 0.6719
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0045 0.0068 0.0077
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0168 0.0591 0.0589
Schistosoma mansoni hypothetical protein 0.0409 0.1611 0.161
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Schistosoma mansoni hypothetical protein 0.0102 0.0309 0.0307
Schistosoma mansoni hypothetical protein 0.0168 0.0591 0.0589
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus granulosus membrane bound transcription factor site 1 0.0057 0.0122 0.0122
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Onchocerca volvulus 0.0036 0.0031 0.033
Loa Loa (eye worm) hypothetical protein 0.0236 0.0877 0.1013
Echinococcus granulosus cyclin dependent kinase 5 0.0043 0.0061 0.0061
Echinococcus granulosus sex peptide receptor 0.0168 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0341 0.1322 0.4791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Schistosoma mansoni opsin-like receptor 0.0168 0.0591 0.0589
Plasmodium falciparum ribosomal RNA methyltransferase, putative 0.003 0.0005 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Onchocerca volvulus 0.0033 0.0018 0.0189
Onchocerca volvulus 0.0168 0.0591 0.6719
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0135 0.0133
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.0061 0.1532
Schistosoma mansoni hypothetical protein 0.0168 0.0591 0.0589
Echinococcus multilocularis rrna methyltransferase 3 0.003 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0033
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0149 0.3943
Echinococcus granulosus neuropeptide Y receptor 0.0168 0.0591 0.0591
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0668 0.2708 0.3132
Entamoeba histolytica hypothetical protein 0.0036 0.003 0.0208
Echinococcus granulosus cathepsin l1 0.003 0.0005 0.0005
Brugia malayi Cathepsin L-like precursor 0.003 0.0005 0.0004
Echinococcus multilocularis serotonin receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis fmrfamide receptor 0.0168 0.0591 0.0589
Trypanosoma brucei subtilisin peptidase 0.0057 0.0122 0.3205
Echinococcus multilocularis cathepsin L cysteine protease 0.0045 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0068 0.1718
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Schistosoma mansoni cyclin B 0.0116 0.0369 0.0368
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0043 0.0061 0.0069
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0022 0.0024
Schistosoma mansoni hypothetical protein 0.0113 0.0357 0.0355
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0168 0.0591 0.0589
Plasmodium falciparum cysteine repeat modular protein 1 0.0113 0.0357 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus granulosus tissue type plasminogen activator 0.0113 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.003 0.0005 0.0004
Echinococcus granulosus rrna methyltransferase 3 0.003 0.0005 0.0005
Schistosoma mansoni myosin xvIII 0.0168 0.0591 0.0589
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0135 0.2242
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0045 0.0068 0.0229
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0031 0.0033
Brugia malayi putative neuropeptide receptor NPR1 0.0168 0.0591 0.0682
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0149 0.3486
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0168 0.0591 0.0682
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Schistosoma mansoni amine GPCR 0.0168 0.0591 0.0589
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Mycobacterium ulcerans lipase LipD 0.0036 0.0031 0.0237
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Echinococcus multilocularis enteropeptidase 0.0033 0.0018 0.0017
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0057 0.0122 0.1795
Toxoplasma gondii ABC1 family protein 0.0036 0.0031 0.0814
Schistosoma mansoni furin-1 (S08 family) 0.0584 0.2353 0.2352
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0135 0.375
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0168 0.0591 0.0682
Toxoplasma gondii subtilisin SUB12 0.0086 0.0241 0.673
Loa Loa (eye worm) melatonin receptor type 1A 0.0168 0.0591 0.0682
Onchocerca volvulus Cathepsin L homolog 0.0045 0.0068 0.0754
Brugia malayi jmjC domain containing protein 0.0159 0.0554 0.0639
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Onchocerca volvulus 0.0168 0.0591 0.6719
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi cell division control protein 2 homolog 0.0043 0.0061 0.0069
Brugia malayi sulfakinin receptor protein 0.0168 0.0591 0.0682
Toxoplasma gondii subtilisin SUB10 0.0057 0.0122 0.338
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0159 0.0554 0.0554
Echinococcus multilocularis cyclin dependent kinase 0.0043 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0209 0.0765 0.0884
Trichomonas vaginalis cyclin D, putative 0.0048 0.0083 0.0284
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0005 0.0003
Echinococcus multilocularis Furin 1 0.0341 0.1322 0.132
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0031 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0168 0.0591 0.0589
Loa Loa (eye worm) TK/EGFR protein kinase 0.0123 0.04 0.046
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Loa Loa (eye worm) hypothetical protein 0.005 0.0089 0.0101
Plasmodium vivax vivapain-2 0.0045 0.0068 0.1862
Echinococcus multilocularis somatostatin receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0168 0.0591 0.0589
Onchocerca volvulus Putative ribosomal RNA methyltransferase 0.003 0.0005 0.0038
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Onchocerca volvulus 0.0168 0.0591 0.6719
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0045 0.0068 0.1862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0089 0.0101
Echinococcus multilocularis G-protein coupled receptor, putative 0.0168 0.0591 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Echinococcus granulosus neuropeptides capa receptor 0.0168 0.0591 0.0591
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0018 0.0017
Echinococcus granulosus peptide allatostatin:somatostatin 0.0168 0.0591 0.0591
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Mycobacterium ulcerans beta-lactamase 0.0036 0.0031 0.0237
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Schistosoma mansoni opsin-like receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis cyclin dependent kinase 1 0.0043 0.0061 0.0059
Onchocerca volvulus 0.0168 0.0591 0.6719
Brugia malayi Serotonin receptor 0.0168 0.0591 0.0682
Schistosoma mansoni neuropeptide receptor 0.0168 0.0591 0.0589
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trypanosoma brucei RNA helicase, putative 0.0102 0.0309 0.8344
Schistosoma mansoni cyclin B3 0.0048 0.0083 0.0081
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Loa Loa (eye worm) G-protein coupled receptor 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Onchocerca volvulus Cathepsin F homolog 0.0045 0.0068 0.0754
Echinococcus granulosus cathepsin l cysteine peptidase 0.0045 0.0068 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0591 0.0591
Echinococcus granulosus lysine specific demethylase 5A 0.0099 0.0299 0.0299
Brugia malayi Trypsin-like protease protein 5 0.0033 0.0018 0.0019
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Onchocerca volvulus 0.0168 0.0591 0.6719
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0043 0.0061 0.0899
Entamoeba histolytica cysteine proteinase, putative 0.0045 0.0068 0.0513
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0149 0.0147
Entamoeba histolytica cyclin, putative 0.0116 0.0369 0.2974
Onchocerca volvulus 0.0116 0.0369 0.4193
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0057 0.0122 0.1989
Echinococcus multilocularis 0.0946 0.3884 0.3883
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0002 0.0002
Trypanosoma cruzi cdc2-related kinase 3 0.0043 0.0061 0.1532
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0033 0.0018 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0005 0.0002
Onchocerca volvulus 0.0048 0.0082 0.0918
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Schistosoma mansoni site-1 peptidase (S08 family) 0.0057 0.0122 0.012
Echinococcus granulosus orexin receptor type 2 0.0168 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Schistosoma mansoni amine GPCR 0.0168 0.0591 0.0589
Plasmodium falciparum protein kinase 5 0.0043 0.0061 0.1671
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0113 0.0357 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0113 0.0357 0.0411
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0031 0.0093
Brugia malayi G-protein coupled receptor 0.0168 0.0591 0.0682
Schistosoma mansoni biogenic amine (5HT) receptor 0.0168 0.0591 0.0589
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0057 0.0122 0.1113
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0057 0.0122 0.32
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0168 0.0591 0.0682
Trichomonas vaginalis cyclin B, putative 0.0116 0.0369 0.1326
Echinococcus multilocularis neuroendocrine convertase 2 0.0868 0.3553 0.3552
Schistosoma mansoni site-1 peptidase (S08 family) 0.0057 0.0122 0.012
Onchocerca volvulus 0.003 0.0005 0.0034
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0168 0.0591 0.0589
Brugia malayi Trypsin family protein 0.0033 0.0018 0.0019
Onchocerca volvulus 0.0168 0.0591 0.6719
Brugia malayi AKH receptor 0.0168 0.0591 0.0682
Echinococcus granulosus fmrfamide receptor 0.0168 0.0591 0.0591
Brugia malayi ORL1-like opioid receptor 0.0168 0.0591 0.0682
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0043 0.0061 0.0899
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0083 0.0284
Toxoplasma gondii ribosomal RNA large subunit methyltransferase J protein 0.003 0.0005 0.0094
Echinococcus multilocularis cyclins 0.0048 0.0083 0.0081
Toxoplasma gondii subtilisin SUB8 0.0057 0.0122 0.338
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0057 0.0122 0.0122
Onchocerca volvulus 0.0168 0.0591 0.6719
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0057 0.0122 0.1113
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0033 0.0018 0.0017
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0045 0.0068 0.0066
Trichomonas vaginalis cyclins, putative 0.0079 0.0214 0.0761
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.003 0.0029
Brugia malayi beta-lactamase family protein 0.0036 0.0031 0.0033
Schistosoma mansoni amine GPCR 0.0168 0.0591 0.0589
Giardia lamblia Cyclin A 0.0048 0.0083 0.0579
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0133 0.0152
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0283 0.1078 0.3906
Echinococcus granulosus peregrin 0.0029 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0031 0.0702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0045 0.0068 0.1724
Giardia lamblia Kinase, CMGC CDK 0.0043 0.0061 0.0422
Toxoplasma gondii subtilisin SUB9 0.0057 0.0122 0.338
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0061 0.0204
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0033
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Loa Loa (eye worm) neuropeptide F receptor 0.0168 0.0591 0.0682
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Echinococcus multilocularis jumonji domain containing protein 0.004 0.005 0.0048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.123 0.4457
Trichomonas vaginalis cyclins, putative 0.0116 0.0369 0.1326
Loa Loa (eye worm) trypsin family protein 0.0033 0.0018 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0045 0.0068 0.0229
Echinococcus multilocularis serotonin receptor 0.0168 0.0591 0.0589
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0057 0.0122 0.1989
Plasmodium vivax ribosomal RNA large subunit methyltransferase J, putative 0.003 0.0005 0.0094
Onchocerca volvulus 0.0168 0.0591 0.6719
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0168 0.0591 0.0589
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0031 0.0237
Echinococcus multilocularis neuropeptides capa receptor 0.0168 0.0591 0.0589
Loa Loa (eye worm) cyclin domain-containing protein 0.0048 0.0083 0.0094
Schistosoma mansoni tyrosine kinase 0.0123 0.04 0.0398
Brugia malayi Tachykinin-like peptides receptor 99D 0.207 0.8642 1
Trichomonas vaginalis CMGC family protein kinase 0.0043 0.0061 0.0204
Brugia malayi hypothetical protein 0.0033 0.0018 0.0019
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0149 0.017
Trichomonas vaginalis cyclin D, putative 0.0048 0.0083 0.0284
Loa Loa (eye worm) hypothetical protein 0.0172 0.0606 0.0699
Echinococcus multilocularis cyclins 0.0048 0.0083 0.0081
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0168 0.0591 0.0591
Echinococcus granulosus cyclin B3 1 0.0048 0.0083 0.0083
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0031 0.0237
Trypanosoma cruzi cysteine peptidase, putative 0.0045 0.0068 0.1718
Leishmania major cathepsin L-like protease 0.0045 0.0068 0.1099
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Brugia malayi Dopamine receptor 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0005 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Echinococcus granulosus tm gpcr rhodopsin 0.0168 0.0591 0.0591
Loa Loa (eye worm) hypothetical protein 0.0168 0.0591 0.0682
Toxoplasma gondii hypothetical protein 0.0037 0.0034 0.0904
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0043 0.0061 0.0061
Trypanosoma cruzi cruzipain precursor, putative 0.0045 0.0068 0.1718
Loa Loa (eye worm) hypothetical protein 0.0113 0.0357 0.0411
Brugia malayi Subtilase family protein 0.0057 0.0122 0.0139
Loa Loa (eye worm) hypothetical protein 0.0036 0.0031 0.0033
Echinococcus granulosus serotonin receptor 0.0168 0.0591 0.0591
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0168 0.0591 0.0589
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0168 0.0591 0.0589
Schistosoma mansoni lipoxygenase 0.008 0.0216 0.0214
Plasmodium vivax subtilisin-like serine protease, putative 0.0057 0.0122 0.338
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0122 0.0425
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0057 0.0122 0.0139
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0019
Onchocerca volvulus 0.0033 0.0018 0.0189
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0057 0.0122 0.0425
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0168 0.0591 0.0589
Schistosoma mansoni cercarial elastase (S01 family) 0.0033 0.0018 0.0017
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0089 0.0101
Toxoplasma gondii cathepsin CPL 0.0045 0.0068 0.1862
Trichomonas vaginalis conserved hypothetical protein 0.026 0.0979 0.3545
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0135 0.2242
Schistosoma mansoni growth hormone secretagogue receptor 0.0168 0.0591 0.0589
Plasmodium vivax SET domain protein, putative 0.003 0.0005 0.0083
Echinococcus granulosus microtubule associated protein 2 0.142 0.5891 0.5891
Giardia lamblia Fructose-bisphosphate aldolase 0.0319 0.123 0.8724
Brugia malayi Dopamine receptor protein 2 0.0168 0.0591 0.0682
Giardia lamblia High cysteine membrane protein Group 2 0.0362 0.1409 1
Brugia malayi neuropeptide F receptor 0.0168 0.0591 0.0682
Onchocerca volvulus 0.0168 0.0591 0.6719
Echinococcus granulosus rhodopsin orphan GPCR 0.0168 0.0591 0.0591
Echinococcus multilocularis dnaJ subfamily B 0.0409 0.1611 0.161
Echinococcus multilocularis G protein coupled receptor 139 0.239 1 1
Loa Loa (eye worm) G-protein coupled receptor 0.0168 0.0591 0.0682
Echinococcus multilocularis glycoprotein Antigen 5 0.0033 0.0018 0.0017
Brugia malayi hypothetical protein 0.0168 0.0591 0.0682
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0045 0.0068 0.0229
Giardia lamblia Furin precursor putative serine protease 0.0283 0.1078 0.7649
Echinococcus granulosus cyclins 0.0048 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0168 0.0591 0.0589
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0135 0.1274
Onchocerca volvulus 0.0045 0.0068 0.0754
Brugia malayi cathepsin L-like precursor 0.003 0.0005 0.0004
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0057 0.0122 0.012
Toxoplasma gondii subtilisin SUB5 0.0057 0.0122 0.338
Echinococcus multilocularis cysteine protease 0.0045 0.0068 0.0066
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0057 0.0122 0.012
Loa Loa (eye worm) hypothetical protein 0.0033 0.0018 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0168 0.0591 0.0589
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0383 0.0441
Echinococcus granulosus alpha 1A adrenergic receptor 0.0168 0.0591 0.0591
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0757 0.0874
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0081 0.0221 0.0219
Brugia malayi Cathepsin L-like precursor 0.0045 0.0068 0.0077

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 1964.3 nM Antagonist activity at cloned muscarinic M1 receptor expressed in CHO cells by measuring calcium mobilization ChEMBL. 17911022
IC50 (functional) = 2157.2 nM Antagonist activity at cloned muscarinic M2 receptor expressed in CHO cells by measuring calcium mobilization ChEMBL. 17911022
IC50 (functional) = 2310.7 nM Antagonist activity at cloned muscarinic M3 receptor expressed in CHO cells by measuring calcium mobilization ChEMBL. 17911022

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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