Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hexokinase | 0.0999 | 1 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0085 | 0.0572 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0085 | 0.0572 | 0.0552 |
Echinococcus multilocularis | snurportin 1 | 0.0333 | 0.3136 | 0.3122 |
Leishmania major | hexokinase, putative | 0.0999 | 1 | 0.5 |
Plasmodium falciparum | importin beta, putative | 0.0031 | 0.0021 | 0.0021 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.0572 | 0.0572 |
Trypanosoma brucei | hexokinase, putative | 0.0999 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.008 | 0.0059 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0256 | 0.0235 |
Echinococcus multilocularis | hexokinase | 0.0999 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0309 | 0.2886 | 0.2871 |
Entamoeba histolytica | hexokinase 1 | 0.0999 | 1 | 0.5 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0055 | 0.0272 | 0.0251 |
Brugia malayi | RNA, U transporter 1 | 0.0089 | 0.0615 | 0.0595 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.0572 |
Loa Loa (eye worm) | hexokinase | 0.0627 | 0.6162 | 0.6153 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0333 | 0.3136 | 0.3122 |
Echinococcus granulosus | hexokinase | 0.0999 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0999 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0085 | 0.0572 | 0.0572 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0256 | 0.0235 |
Loa Loa (eye worm) | hexokinase type II | 0.0999 | 1 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0085 | 0.0572 | 0.0552 |
Brugia malayi | Hexokinase family protein | 0.0309 | 0.2886 | 0.2871 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.2974 | 0.2959 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.0572 |
Echinococcus multilocularis | hexokinase | 0.0999 | 1 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.0552 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0055 | 0.0272 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.0552 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0256 | 0.0235 |
Echinococcus granulosus | hexokinase type 2 | 0.0999 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0999 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0999 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0999 | 1 | 1 |
Plasmodium vivax | hexokinase, putative | 0.0999 | 1 | 1 |
Echinococcus multilocularis | hexokinase type 2 | 0.0999 | 1 | 1 |
Onchocerca volvulus | 0.0999 | 1 | 1 | |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.5 |
Echinococcus granulosus | snurportin 1 | 0.0333 | 0.3136 | 0.3122 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0055 | 0.0272 | 0.4744 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0256 | 0.0235 |
Trypanosoma cruzi | hexokinase, putative | 0.0999 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.0999 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.008 | 0.0059 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0055 | 0.0272 | 0.0251 |
Trypanosoma brucei | hexokinase | 0.0999 | 1 | 1 |
Onchocerca volvulus | 0.0999 | 1 | 1 | |
Brugia malayi | hexokinase type II | 0.0318 | 0.2974 | 0.2959 |
Trypanosoma cruzi | hexokinase, putative | 0.0999 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0572 | 0.0552 |
Schistosoma mansoni | hypothetical protein | 0.0333 | 0.3136 | 0.3122 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.008 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0681 | 0.6725 | 0.6718 |
Loa Loa (eye worm) | hexokinase | 0.0999 | 1 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0031 | 0.0021 | 0.0021 |
Loa Loa (eye worm) | hypothetical protein | 0.0318 | 0.2974 | 0.2959 |
Plasmodium falciparum | hexokinase | 0.0999 | 1 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0999 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0999 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0999 | 1 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0999 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0999 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0627 | 0.6162 | 0.6153 |
Plasmodium vivax | importin-beta 2, putative | 0.0031 | 0.0021 | 0.0021 |
Onchocerca volvulus | 0.0999 | 1 | 1 | |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0085 | 0.0572 | 0.0572 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0055 | 0.0272 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0085 | 0.0572 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 23.3 uM | Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | ChEMBL. | 24411477 |
Inhibition (binding) | = 75 % | Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx at 100 uM preincubated for 30 mins followed by ATP addition by Fluo-4 AM dye-based fluorescence assay | ChEMBL. | 24411477 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.