Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 3, subfamily A, polypeptide 4 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | cytochrome P450 | cytochrome P450, family 3, subfamily A, polypeptide 4 | 502 aa | 492 aa | 24.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0587 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0587 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.0074 | 0.0074 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0587 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0587 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0587 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0015 | 0.0074 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0587 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0587 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0587 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0587 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0587 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0015 | 0.0074 | 0.0074 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0587 | 1 | 1 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0587 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0015 | 0.0074 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0587 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0587 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0587 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0587 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0587 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0587 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0587 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0587 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 7 nM | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 6 amastigotes infected in rat L6 cells after 96 hrs by colorimetric method | ChEMBL. | 24304150 |
IC50 (ADMET) | = uM | DNDI | DNDI. | No reference |
IC50 (functional) | = 0.007 uM | DNDI: Chagas in Vitro | ChEMBL. | No reference |
IC50 (ADMET) | = 4 uM | DNDI | DNDI. | No reference |
IC90 (functional) | = 0.013 uM | DNDI: Chagas in Vitro | ChEMBL. | No reference |
Inhibition (functional) | = 51.5 % | DNDI: Inhibition of formation of Leishmania donovani | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 24304150 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.