Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | prostaglandin-endoperoxide synthase 1 | Starlite/ChEMBL | References |
Mus musculus | prostaglandin-endoperoxide synthase 2 | Starlite/ChEMBL | References |
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0111 | 0.5262 | 0.5 | |
Onchocerca volvulus | 0.0111 | 0.5262 | 0.5 | |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0165 | 0.9616 | 1 |
Echinococcus granulosus | peroxidasin | 0.0111 | 0.5262 | 0.5308 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.017 | 1 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0046 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0111 | 0.5262 | 0.5 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0046 | 0 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0111 | 0.5262 | 0.5 |
Onchocerca volvulus | 0.0111 | 0.5262 | 0.5 | |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.005 | 0.0335 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0111 | 0.5262 | 0.5 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.005 | 0.0335 | 0.5 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.017 | 1 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0111 | 0.5262 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.017 | 1 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.005 | 0.0335 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0111 | 0.5262 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.005 | 0.0335 | 0.5 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.005 | 0.0335 | 0.5 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0046 | 0 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0111 | 0.5262 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 54 % | Analgesic activity in Swiss albino mouse assessed as reduction of acetic acid-induced writhing at 20 mg/kg, po measured every 10 mins after 5 mins of administration relative to control | ChEMBL. | 24373735 |
IC50 (binding) | = 1600 nM | In Vitro Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1600 nM | In Vitro Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1.6 uM | Inhibition of LPS-induced COX-2 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of prostaglandin E2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by RIA | ChEMBL. | 24373735 |
IC50 (binding) | = 1.6 uM | Inhibition of COX2 in Escherichia coli LPS-stimulated mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay | PATENT. | No reference |
IC50 (binding) | > 10 uM | Inhibition of COX-1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of prostaglandin E2 production preincubated for 15 mins followed by substrate addition measured after 30 mins by RIA | ChEMBL. | 24373735 |
Inhibition (binding) | = 6 % | Inhibition of COX-1 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of prostaglandin E2 production at 10 uM preincubated for 15 mins followed by substrate addition measured after 30 mins by RIA | ChEMBL. | 24373735 |
Inhibition (binding) | < 20 % | Inhibition of COX1 in mouse J774 cells using arachidonic acid as substrate assessed as decrease in PGE2 production at 10 uM preincubated for 15 mins followed by substrate addition measured after 30 mins by radioimmunoassay relative to control | PATENT. | No reference |
Inhibition (binding) | = 89 % | Inhibition of LPS-induced COX-2 in mouse J774 cells using arachidonic acid as substrate assessed as inhibition of prostaglandin E2 production at 10 uM preincubated for 15 mins followed by substrate addition measured after 30 mins by RIA | ChEMBL. | 24373735 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.