Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0032 | 0.069 | 0.069 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0053 | 0.1571 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.0918 | 0.5844 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0053 | 0.1571 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1104 | 0.7025 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0018 | 0.0114 | 0.0561 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.005 | 0.1457 | 0.6642 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.069 | 0.3394 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0019 | 0.0142 | 0.0163 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0254 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0022 | 0.0289 | 0.0289 |
Echinococcus granulosus | dna polymerase eta | 0.0022 | 0.0289 | 0.1424 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0289 | 0.1424 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0022 | 0.0289 | 0.1842 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0022 | 0.0289 | 0.1424 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0289 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0022 | 0.0289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1457 | 0.1673 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1009 | 0.1158 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0289 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0064 | 0.2032 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0227 | 0.1037 |
Giardia lamblia | DINP protein human, muc B family | 0.0022 | 0.0289 | 0.5 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0035 | 0.1214 |
Trypanosoma brucei | ISWI complex protein | 0.0016 | 0.0035 | 0.1214 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0022 | 0.0289 | 0.1424 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0053 | 0.1571 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.1104 | 0.5431 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1009 | 0.1158 |
Leishmania major | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 0.1842 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0289 | 0.1842 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.0289 | 0.0332 |
Echinococcus multilocularis | dna polymerase eta | 0.0022 | 0.0289 | 0.1424 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0053 | 0.1571 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1009 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1073 | 0.1232 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.005 | 0.1457 | 0.7168 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0114 | 0.052 |
Leishmania major | DNA polymerase eta, putative | 0.0022 | 0.0289 | 0.1842 |
Trypanosoma cruzi | ISWI complex protein | 0.0016 | 0.0035 | 0.1214 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.004 | 0.1009 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0016 | 0.0035 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1571 | 0.1804 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0053 | 0.1571 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.005 | 0.1457 | 0.6642 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.107 | 0.1228 |
Mycobacterium ulcerans | hypothetical protein | 0.0053 | 0.1571 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0022 | 0.0289 | 0.1319 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0289 | 0.0332 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.0918 | 0.5844 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0223 | 0.8707 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0289 | 0.1842 |
Echinococcus multilocularis | zinc finger protein | 0.0021 | 0.0227 | 0.112 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0022 | 0.0289 | 0.0289 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.004 | 0.1009 | 0.6421 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1104 | 0.7025 |
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0467 | 0.0537 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0035 | 0.016 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0053 | 0.1571 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0361 | 0.1776 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.1104 | 0.5431 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.1104 | 0.5032 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0289 | 0.1842 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0022 | 0.0289 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0022 | 0.0289 | 0.1319 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0963 | 0.4739 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.1571 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1265 | 0.1453 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.1571 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0275 | 0.1254 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1571 | 0.1804 |
Schistosoma mansoni | zinc finger protein | 0.0016 | 0.0035 | 0.016 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.1571 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.069 | 0.6837 |
Schistosoma mansoni | DNA polymerase eta | 0.0022 | 0.0289 | 0.1319 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0022 | 0.0289 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0053 | 0.1571 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0022 | 0.0289 | 0.0332 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0018 | 0.0114 | 0.0561 |
Echinococcus granulosus | zinc finger protein | 0.0021 | 0.0227 | 0.112 |
Echinococcus multilocularis | dna polymerase kappa | 0.0022 | 0.0289 | 0.1424 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.069 | 0.3145 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0022 | 0.0289 | 0.1842 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0064 | 0.2032 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0068 | 0.2193 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.272 | 0.3124 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.1571 | 0.1804 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.1571 | 0.1804 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0963 | 0.4739 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.069 | 0.3145 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0361 | 0.1776 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.1104 | 0.5032 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.069 | 0.0792 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.069 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0289 | 0.0332 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0053 | 0.1571 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0361 | 0.1646 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0053 | 0.1571 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1009 | 0.1158 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1179 | 0.1354 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0053 | 0.1571 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.0918 | 0.5844 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.1571 | 1 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0018 | 0.0114 | 0.052 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.064 | 0.3151 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0289 | 0.1842 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1104 | 0.7025 |
Brugia malayi | hypothetical protein | 0.0042 | 0.1104 | 0.1267 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.004 | 0.1009 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.1104 | 0.7025 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2528 | 0.2903 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.004 | 0.1009 | 0.6421 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.005 | 0.1457 | 0.7168 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1009 | 0.1158 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0053 | 0.1571 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1571 | 0.1804 |
Trypanosoma brucei | unspecified product | 0.0022 | 0.0289 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0038 | 0.0918 | 0.5844 |
Brugia malayi | AMP-binding enzyme family protein | 0.0053 | 0.1571 | 0.1804 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0022 | 0.0289 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.004 | 0.1009 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0053 | 0.1571 | 1 |
Onchocerca volvulus | 0.0053 | 0.1571 | 0.1571 | |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0275 | 0.0316 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0053 | 0.1571 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0223 | 0.8707 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.