Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sphingosine-1-phosphate receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | sphingosine-1-phosphate receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.2925 | 0.2925 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.2925 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.2925 | 1 |
Echinococcus granulosus | lamin | 0.0026 | 0.2925 | 0.2925 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2821 | 0.9646 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.2925 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 1 | 0.5 |
Echinococcus multilocularis | musashi | 0.0026 | 0.2925 | 0.2925 |
Onchocerca volvulus | 0.0026 | 0.2925 | 0.5 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.03 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2925 | 1 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.2925 | 1 |
Echinococcus multilocularis | lamin | 0.0026 | 0.2925 | 0.2925 |
Onchocerca volvulus | 0.0026 | 0.2925 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.2925 | 0.2925 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 10000 nM | Agonist activity at human recombinant S1P3 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis | ChEMBL. | 24266709 |
EC50 (functional) | > 10000 nM | Agonist activity at human recombinant S1P1 receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding preincubated for 30 mins followed by [35S]GTPgammaS addition measured after 1 hr by topcount scintillation counting analysis | ChEMBL. | 24266709 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.