TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 444.974 | Formula: C23H25ClN2O3S
H donors: 1 H acceptors: 2 LogP: 4.87 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H](CN1CCC2(CC1)Cc1c(O2)ccc(c1)Cl)COc1cccc2c1nc(s2)C
InChi: 1S/C23H25ClN2O3S/c1-15-25-22-20(3-2-4-21(22)30-15)28-14-18(27)13-26-9-7-23(8-10-26)12-16-11-17(24)5-6-19(16)29-23/h2-6,11,18,27H,7-10,12-14H2,1H3/t18-/m0/s1
InChiKey: CVGAXTRRJOEDEZ-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-C motif) receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	chemokine (C-C motif) receptor 1	355 aa	289 aa	21.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	activin receptor type	0.0113	1	1
Giardia lamblia	Protein 21.1	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0113	0.9957	0.9954
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	protein tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0113	0.9957	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0071	0.4977	0.4998
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0111	0.9738	0.978
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0113	0.9957	1
Giardia lamblia	Kinase, NEK	0.0113	0.9957	1
Echinococcus granulosus	protein kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.9738	0.968
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0113	1	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	protein tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Echinococcus granulosus	protein tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/INSR protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Echinococcus granulosus	tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0113	0.9957	0.9954
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0113	0.9957	0.9954
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Brugia malayi	Receptor family ligand binding region containing protein	0.0113	0.9957	1
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.9738	0.968
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0113	0.9957	0.9957
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0113	0.9957	0.9957
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0113	0.9957	0.9954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.9738	0.968
Echinococcus granulosus	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	activin receptor type	0.0113	1	1
Echinococcus granulosus	tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0113	0.9957	1
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0113	0.9957	0.9954
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0113	0.9957	0.9954
Brugia malayi	SH2 domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.9738	0.968
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK/DDR protein kinase	0.0113	0.9957	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0111	0.9738	0.9764
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Giardia lamblia	Kinase, PLK	0.0111	0.9738	0.9764
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Plasmodium falciparum	protein kinase, putative	0.0113	0.9957	0.9957
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0113	0.9957	0.9954
Onchocerca volvulus		0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0113	0.9957	0.9954
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.1515	0.0913
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0113	0.9957	0.9954
Schistosoma mansoni	hypothetical protein	0.0113	0.9957	0.9954
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase domain containing protein	0.0113	1	1
Giardia lamblia	Kinase	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0113	0.9957	0.9957
Onchocerca volvulus		0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0113	0.9957	0.9957
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0113	0.9957	0.9954
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.3557	0.3572
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0113	0.9957	0.9954
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.9738	0.9738
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Entamoeba histolytica	ankyrin repeat protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0112	0.9881	0.9872
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Schistosoma mansoni	serine/threonine protein kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	insulin receptor	0.0113	0.9957	0.9954
Echinococcus multilocularis	protein kinase	0.0113	0.9957	0.9954
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0113	0.9957	0.9954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0113	0.9957	0.9954
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.2968	0.2469
Leishmania major	hypothetical protein, conserved	0.0113	0.9957	0.9957
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Brugia malayi	SH2 domain containing protein	0.0113	0.9957	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0041	0.1515	0.1522
Echinococcus granulosus	kinase suppressor of Ras 1	0.0113	0.9957	0.9954
Entamoeba histolytica	ankyrin repeat protein	0.0113	0.9957	0.8369
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.9738	0.9738
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	hypothetical protein	0.0113	0.9957	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Echinococcus granulosus	activated cdc42 kinase 1	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Schistosoma mansoni	protein kinase	0.0113	1	1
Toxoplasma gondii	protein kinase	0.0113	0.9957	0.9957
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0111	0.9738	0.9738
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0113	0.9957	0.9954
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0113	0.9957	1
Brugia malayi	hypothetical protein	0.0113	0.9957	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0113	0.9957	0.9957
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.9957	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0113	0.9957	0.9954
Echinococcus granulosus	tyrosine protein kinase Blk	0.0113	0.9957	0.9954
Echinococcus multilocularis	jumonji domain containing protein	0.0048	0.2249	0.1699
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0113	0.9957	0.9954
Loa Loa (eye worm)	serine/threonine protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0113	0.9957	0.9954
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.2968	0.2981
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0113	0.9957	0.9954
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	epidermal growth factor receptor	0.0113	0.9957	0.9954
Echinococcus granulosus	c src tyrosine kinase	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Brugia malayi	Tyrosine-protein kinase abl-1	0.0113	0.9957	1
Entamoeba histolytica	tyrosin kinase, putative	0.0113	0.9957	0.8369
Echinococcus multilocularis	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0113	0.9957	0.9954
Trichomonas vaginalis	CAMK family protein kinase	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	integrin linked protein kinase	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0113	0.9957	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.2968	0.2469
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0113	0.9957	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0113	0.9957	0.9954
Brugia malayi	hypothetical protein	0.0113	0.9957	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0113	0.9957	1
Schistosoma mansoni	serine/threonine protein kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Onchocerca volvulus		0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	serine/threonine kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0041	0.1515	0.0913
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.9957	1
Entamoeba histolytica	receptor protein kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Entamoeba histolytica	tyrosin kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	tyrosine protein kinase csk	0.0113	0.9957	0.9954
Echinococcus multilocularis	insulin receptor	0.0113	0.9957	0.9954
Schistosoma mansoni	protein kinase	0.0113	1	1
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Echinococcus multilocularis	c src tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	lysine specific demethylase 5A	0.0041	0.1515	0.0913
Plasmodium falciparum	protein kinase, putative	0.0113	0.9957	0.9957
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0113	0.9957	0.9954
Loa Loa (eye worm)	PHD-finger family protein	0.0034	0.0663	0.0665
Toxoplasma gondii	STE kinase	0.0113	0.9957	0.9957
Echinococcus multilocularis	tyrosine protein kinase shark	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/ALK protein kinase	0.0113	0.9957	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.2968	0.2469
Onchocerca volvulus		0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Brugia malayi	PHD-finger family protein	0.0034	0.0663	0.0665
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0663	0.0665
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0113	0.9957	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0113	0.9957	0.9954
Echinococcus multilocularis	heat shock protein 70	0.0113	0.9957	0.9954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0113	0.9957	0.9954
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.9738	0.968
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0113	0.9957	0.9954
Echinococcus multilocularis	transfer RNA-Thr	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	FL cytokine receptor	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0113	0.9957	0.9954
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Brugia malayi	Furin-like cysteine rich region family protein	0.0113	0.9957	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0113	0.9957	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Leishmania major	protein kinase, putative	0.0113	1	1
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0113	0.9957	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0113	1	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0113	0.9957	0.9954
Plasmodium vivax	protein kinase, putative	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Entamoeba histolytica	tyrosin kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	Bromodomain containing protein	0.0034	0.0663	0.0665
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0111	0.9738	0.9719
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.2968	0.2469
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	SRC-1	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	tyrosin kinase, putative	0.0113	0.9957	0.8369
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TK family protein kinase	0.0113	0.9957	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0111	0.9738	0.978
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0113	0.9957	0.9954
Echinococcus granulosus	tyrosine protein kinase csk	0.0113	0.9957	0.9954
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	cysteine surface protein, putative	0.0113	0.9957	0.8369
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.2968	0.2469
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0113	0.9957	0.9957
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/ABL protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Onchocerca volvulus		0.0113	0.9957	1
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0113	0.9957	0.9954
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Giardia lamblia	Kinase, NEK	0.0113	0.9957	1
Brugia malayi	Raf kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Schistosoma mansoni	protein kinase	0.0113	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.2968	0.2469
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0113	0.9957	0.9954
Echinococcus granulosus	epidermal growth factor receptor	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0113	0.9957	1
Schistosoma mansoni	serine/threonine RGC	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Plasmodium falciparum	phd finger protein, putative	0.0034	0.0663	0.0663
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0113	0.9957	0.9954
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	serine/threonine kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0113	0.9957	0.9954
Echinococcus granulosus	raf serine:threonine protein kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0113	0.9957	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0113	0.9957	0.9957
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK/ROR protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Trypanosoma cruzi	protein kinase, putative	0.0113	0.9957	0.9957
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0113	0.9957	0.9954
Schistosoma mansoni	serine/threonine protein kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Schistosoma mansoni	jumonji domain containing protein	0.0089	0.7153	0.6951
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.9957	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0113	0.9957	0.9954
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Brugia malayi	ephrin receptor 1 precursor	0.0113	0.9957	1
Schistosoma mansoni	serine/threonine protein kinase	0.0113	0.9957	0.9954
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Brugia malayi	Guanylyl cyclase protein 23	0.0113	0.9957	1
Echinococcus granulosus	lysine specific demethylase 5A	0.0041	0.1515	0.0913
Leishmania major	protein kinase, putative	0.0113	0.9957	0.9957
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	ephrin receptor	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/RYK protein kinase	0.0113	0.9957	1
Echinococcus granulosus	epidermal growth factor receptor	0.0113	0.9957	0.9954
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0113	0.9957	0.9954
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0663	0.0663
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.9738	0.9719
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.9738	0.968
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0113	0.9957	0.9954
Trypanosoma brucei	polo-like protein kinase	0.0111	0.9738	0.9738
Echinococcus granulosus	natriuretic peptide receptor 1	0.0113	0.9957	0.9954
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase	0.0113	0.9957	0.9954
Trypanosoma brucei	Pseudokinase, putative	0.0113	0.9957	0.9957
Brugia malayi	integrin-linked kinase	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	kinase	0.0056	0.3283	0.2806
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Loa Loa (eye worm)	TK/Met protein kinase	0.0113	0.9957	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0113	0.9957	0.9954
Entamoeba histolytica	serine/threonine kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Schistosoma mansoni	tyrosine protein kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	protein-tyrosine kinase	0.0113	0.9957	1
Trichomonas vaginalis	STE family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Echinococcus granulosus	tyrosine protein kinase HCK	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.9957	1
Echinococcus granulosus	jumonji domain containing protein	0.0048	0.2249	0.1699
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0113	0.9957	0.9954
Entamoeba histolytica	serine/threonine kinase, putative	0.0113	0.9957	0.8369
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0113	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0113	0.9957	0.9954
Echinococcus granulosus	activated cdc42 kinase 1	0.0113	0.9957	0.9954
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0663	0.0665
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Schistosoma mansoni	ephrin receptor	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0113	0.9957	0.9954
Trichomonas vaginalis	conserved hypothetical protein	0.0113	0.9957	1
Toxoplasma gondii	PHD-finger domain-containing protein	0.0034	0.0663	0.0663
Trichomonas vaginalis	AGC family protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0113	0.9957	0.9954
Trypanosoma cruzi	protein kinase, putative	0.0113	0.9957	0.9957
Schistosoma mansoni	protein kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Brugia malayi	C-terminal src kinase protein 1	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0113	0.9957	0.9954
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0113	0.9957	0.9954
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0112	0.9881	0.9872
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0113	0.9957	0.9954
Onchocerca volvulus		0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase, putative	0.0113	0.9957	0.8369
Echinococcus multilocularis	protein kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0113	0.9957	0.9954
Trypanosoma brucei	protein kinase, putative	0.0113	1	1
Echinococcus multilocularis	tyrosine kinase	0.0113	0.9957	0.9954
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0113	0.9957	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.2968	0.2469
Entamoeba histolytica	serine/threonine kinase, putative	0.0113	0.9957	0.8369
Entamoeba histolytica	hypothetical protein	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	jmjC domain containing protein	0.0041	0.1515	0.1522
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0113	0.9957	0.9954
Plasmodium falciparum	protein kinase, putative	0.0113	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0113	0.9957	0.9954
Entamoeba histolytica	receptor protein kinase, putative	0.0113	0.9957	0.8369
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0113	0.9957	0.9954
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	hypothetical protein	0.0113	0.9957	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0113	1	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Loa Loa (eye worm)	TK/EPH protein kinase	0.0113	0.9957	1
Entamoeba histolytica	tyrosine kinase, putative	0.0113	0.9957	0.8369
Loa Loa (eye worm)	SRC-1	0.0113	0.9957	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0113	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0113	0.9957	0.8369
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0113	0.9957	0.8369
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Brugia malayi	jmjC domain containing protein	0.0112	0.9881	0.9923
Loa Loa (eye worm)	TK/FAK protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Onchocerca volvulus		0.0113	0.9957	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.9738	0.968
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0113	0.9957	0.9954
Echinococcus granulosus	ephrin type A receptor 4 A	0.0113	0.9957	0.9954
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0111	0.9738	0.9719
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0113	0.9957	0.9954
Entamoeba histolytica	serine/threonine kinase, putative	0.0113	0.9957	0.8369
Echinococcus granulosus	integrin linked protein kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	tyrosine protein kinase csk	0.0113	0.9957	0.9954
Entamoeba histolytica	hypothetical protein, conserved	0.0113	0.9957	0.8369
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0113	1	1
Loa Loa (eye worm)	TK protein kinase	0.0113	0.9957	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0113	0.9957	0.9954
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0113	0.9957	0.9954
Brugia malayi	Tyrosine-protein kinase PR2	0.0113	0.9957	1
Brugia malayi	Protein kinase domain containing protein	0.0113	0.9957	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0113	0.9957	0.9954
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0113	0.9957	0.9954
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0113	0.9957	0.9954
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Trichomonas vaginalis	TKL family protein kinase	0.0113	0.9957	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.2968	0.2981
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0113	0.9957	0.9954
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0113	0.9957	0.9954
Schistosoma mansoni	tyrosine kinase	0.0113	0.9957	0.9954

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)		Displacement of [125I]MIP-1alpha from rat CCR1	ChEMBL.	24332486
IC50 (binding)	= 1.3 uM	Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis	ChEMBL.	24332486

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3099957

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1821118