Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 10 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0201 | 0.0201 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0018 | 0.0463 | 0.5 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0027 | 0.0784 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0278 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1279 | 0.1279 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0024 | 0.0663 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0041 | 0.1279 | 0.1279 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0201 | 0.5 |
Loa Loa (eye worm) | RecQ helicase | 0.0027 | 0.0784 | 0.0595 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1279 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0027 | 0.0784 | 0.0595 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0322 | 0.5 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0027 | 0.0784 | 0.0595 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1279 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0201 | 0.4422 |
Echinococcus granulosus | bloom syndrome protein | 0.0027 | 0.0784 | 0.0595 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0322 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0322 | 0.5 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0278 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.479 | 0.4683 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.6801 | 0.6801 |
Echinococcus multilocularis | geminin | 0.0191 | 0.6801 | 0.6735 |
Echinococcus granulosus | geminin | 0.0191 | 0.6801 | 0.6735 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0278 | 1 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0027 | 0.0784 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0201 | 0.0201 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.6801 | 0.6801 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0201 | 0.4422 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1279 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0018 | 0.0455 | 1 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0278 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0041 | 0.1279 | 0.11 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0021 | 0.0575 | 0.0575 |
Entamoeba histolytica | hypothetical protein | 0.0041 | 0.1279 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0041 | 0.1279 | 0.11 |
Brugia malayi | hypothetical protein | 0.0041 | 0.1279 | 0.11 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0322 | 0.2514 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of JNK1 (unknown origin) | ChEMBL. | 24332487 | |
IC50 (binding) | = 0.523 uM | Inhibition of JNK3 (39 to 402 amino acids) (unknown origin) expressed in Escherichia coli BL21(DE3) using biotinylated ATF2 as substrate after 15 mins by HTRF assay | ChEMBL. | 24332487 |
IC50 (binding) | > 20 uM | Inhibition of p38 (unknown origin) | ChEMBL. | 24332487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.