Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0085 | 0.0085 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0073 | 0.1244 | 0.1244 |
Brugia malayi | Thioredoxin reductase | 0.0073 | 0.1244 | 0.1244 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0013 | 0.0021 | 0.0021 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0019 | 0.0142 | 0.0142 |
Trypanosoma brucei | trypanothione reductase | 0.0073 | 0.1244 | 0.0994 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0455 | 0.0455 |
Leishmania major | trypanothione reductase | 0.0073 | 0.1244 | 0.0994 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0073 | 0.1244 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0508 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0278 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.006 | 0.006 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0774 | 0.0774 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.01 | 0.1776 | 0.1776 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0774 | 0.0774 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0085 | 0.0085 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | nephrin | 0.0015 | 0.006 | 0.006 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0073 | 0.1244 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0774 | 0.0774 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0508 | 1 | 1 |
Treponema pallidum | NADH oxidase | 0.0025 | 0.0278 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0073 | 0.1244 | 0.0994 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0508 | 1 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0085 | 0.0085 |
Echinococcus granulosus | twitchin | 0.0019 | 0.0153 | 0.0153 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.01 | 0.1776 | 0.1776 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.01 | 0.1776 | 0.1776 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.006 | 0.006 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0073 | 0.1244 | 0.0994 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0508 | 1 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0774 | 0.0774 |
Brugia malayi | glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0019 | 0.0142 | 0.0142 |
Echinococcus multilocularis | neuroglian | 0.0015 | 0.006 | 0.006 |
Echinococcus granulosus | roundabout 2 | 0.0015 | 0.006 | 0.006 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0025 | 0.0278 | 0.5 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0025 | 0.0278 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0508 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0508 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0073 | 0.1244 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0103 | 0.1836 | 0.1836 |
Echinococcus granulosus | neuroglian | 0.0015 | 0.006 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0085 | 0.0085 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0508 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0073 | 0.1244 | 1 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0025 | 0.0278 | 0.0278 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0073 | 0.1244 | 0.1244 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0508 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0103 | 0.1836 | 0.1836 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0508 | 1 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | tyrosine kinase | 0.01 | 0.1776 | 0.1776 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0025 | 0.0278 | 0.5 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.01 | 0.1776 | 0.1776 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0025 | 0.0278 | 0.0278 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0278 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0455 | 0.0455 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0013 | 0.0021 | 0.0021 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0508 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0508 | 1 | 1 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0025 | 0.0278 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0508 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0508 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0455 | 0.0455 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0085 | 0.0085 |
Plasmodium falciparum | thioredoxin reductase | 0.0073 | 0.1244 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0015 | 0.006 | 0.006 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0508 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 65 % | Cell Cycle inhibition against mouse lymphocytic leukemia cells (L1210) at 10 microM | ChEMBL. | 10780917 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.