TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 336.388 | Formula: C19H20N4O2
H donors: 1 H acceptors: 2 LogP: 1.7 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NC(=O)n1ccc2c1nc(cc2)c1ccc(cc1)CN1CCOCC1
InChi: 1S/C19H20N4O2/c20-19(24)23-8-7-16-5-6-17(21-18(16)23)15-3-1-14(2-4-15)13-22-9-11-25-12-10-22/h1-8H,9-13H2,(H2,20,24)
InChiKey: QHIIDJMYFYGHEO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	poly (ADP-ribose) polymerase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei	poly(adp-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly ADP ribose polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Neospora caninum	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly adp ribose polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma congolense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei gambiense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (adp ribose) polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2-A, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Onchocerca volvulus		0.0133	0.0425	0.0151
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0133	0.0425	1
Echinococcus multilocularis	roundabout 2	0.0108	0.0289	0.0855
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0133	0.0425	0.2602
Onchocerca volvulus		0.0133	0.0425	0.0151
Echinococcus multilocularis	hypothetical protein	0.0133	0.0425	0.2602
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0095	0.0222	0.0811
Onchocerca volvulus		0.0133	0.0425	0.0151
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Echinococcus granulosus	titin	0.0108	0.0289	0.288
Echinococcus granulosus	Fibronectin type III domain containing protein	0.0108	0.0289	0.288
Echinococcus granulosus	poly adp ribose polymerase 2	0.0095	0.0222	0.2214
Loa Loa (eye worm)	lethal protein 805	0.0108	0.0289	0.0226
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.424
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.424
Echinococcus multilocularis	anosmin 1	0.0108	0.0289	0.0855
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.0108	0.0289	0.0855
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0241	0.1002	1
Schistosoma mansoni	nephrin	0.0108	0.0289	0.1597
Schistosoma mansoni	hypothetical protein	0.0108	0.0289	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus granulosus	titin	0.0108	0.0289	0.288
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0133	0.0425	0.3202
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.424
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.2602
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Schistosoma mansoni	pcd6 interacting protein-related	0.0133	0.0425	0.3202
Onchocerca volvulus	4.1 G protein, putative homolog	0.0133	0.0425	0.0151
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.0108	0.0289	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Brugia malayi	myotactin form A	0.0108	0.0289	0.0068
Echinococcus granulosus	roundabout 2	0.0108	0.0289	0.288
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0108	0.0289	0.0226
Echinococcus granulosus	neuroglian	0.0108	0.0289	0.288
Onchocerca volvulus		0.0133	0.0425	0.0151
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0133	0.0425	0.0208
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0133	0.0425	0.3202
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus granulosus	EG95	0.0108	0.0289	0.288
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Echinococcus granulosus	Netrin receptor DCC	0.0108	0.0289	0.288
Schistosoma mansoni	cell adhesion molecule	0.0108	0.0289	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0133	0.0425	0.3202
Loa Loa (eye worm)	hypothetical protein	0.0132	0.0419	0.0365
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0108	0.0289	0.3288
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus multilocularis	transfer RNA-Phe	0.0108	0.0289	0.0855
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.424
Echinococcus granulosus	anosmin 1	0.0108	0.0289	0.288
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus multilocularis	anosmin 1	0.0108	0.0289	0.0855
Onchocerca volvulus		0.0133	0.0425	0.0151
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Schistosoma mansoni	protein tyrosine phosphatase	0.0133	0.0425	0.3202
Echinococcus granulosus	Netrin receptor DCC	0.0108	0.0289	0.288
Schistosoma mansoni	tripartite motif protein trim9	0.0108	0.0289	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Giardia lamblia	Protein tyrosine phosphatase	0.0133	0.0425	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0133	0.0425	1
Brugia malayi	Fibronectin type III domain containing protein	0.0108	0.0289	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0133	0.0425	0.3202
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.0108	0.0289	0.3288
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Brugia malayi	Fibronectin type III domain containing protein	0.0108	0.0289	0.0068
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0174	0.0641	0.5366
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0108	0.0289	0.0226
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0133	0.0425	0.2602
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0241	0.1002	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.2602
Echinococcus granulosus	fibronectin type III domain-containing protein	0.0108	0.0289	0.288
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0108	0.0289	0.0226
Echinococcus granulosus	cell adhesion molecule	0.0108	0.0289	0.288
Echinococcus multilocularis		0.0133	0.0425	0.2602
Loa Loa (eye worm)	hypothetical protein	0.1813	0.9423	1
Loa Loa (eye worm)	projectin	0.0108	0.0289	0.0226
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Brugia malayi	Protein-tyrosine phosphatase 1	0.0133	0.0425	0.0208
Loa Loa (eye worm)	myotactin form A	0.0108	0.0289	0.0226
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.424
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Echinococcus granulosus	roundabout 2	0.0108	0.0289	0.288
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0133	0.0425	0.2602
Schistosoma mansoni	protein tyrosine phosphatase	0.0133	0.0425	0.3202
Echinococcus multilocularis	Netrin receptor DCC	0.0108	0.0289	0.0855
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0133	0.0425	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0108	0.0289	0.288
Schistosoma mansoni	serine/threonine protein kinase	0.0108	0.0289	0.1597
Schistosoma mansoni	nephrin	0.0108	0.0289	0.1597
Echinococcus multilocularis	titin	0.0108	0.0289	0.0855
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0241	0.1002	1
Echinococcus granulosus	roundabout 2	0.0108	0.0289	0.288
Echinococcus granulosus	anosmin 1	0.0108	0.0289	0.288
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Schistosoma mansoni	factor for adipocyte differentiation	0.0108	0.0289	0.1597
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.2602
Brugia malayi	hypothetical protein	0.0133	0.0425	0.0208
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0133	0.0425	0.2602
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0108	0.0289	0.0226
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0108	0.0289	0.0226
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0133	0.0425	0.3202
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0133	0.0425	0.424
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.424
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.0108	0.0289	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Trichomonas vaginalis	pten, drome, putative	0.0133	0.0425	0.5
Schistosoma mansoni	ephrin receptor	0.0108	0.0289	0.1597
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Echinococcus granulosus	Fibronectin type III	0.0108	0.0289	0.288
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Echinococcus granulosus	G1Y162 protein	0.0108	0.0289	0.288
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0133	0.0425	0.3202
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.424
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.0108	0.0289	0.0855
Echinococcus granulosus	nephrin	0.0108	0.0289	0.288
Loa Loa (eye worm)	hypothetical protein	0.168	0.8709	0.9236
Loa Loa (eye worm)	hypothetical protein	0.168	0.8709	0.9236
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Echinococcus multilocularis	neuroglian	0.0108	0.0289	0.0855
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.424
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0108	0.0289	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0133	0.0425	0.3202
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0133	0.0425	0.0372
Schistosoma mansoni	cell adhesion molecule	0.0108	0.0289	0.1597
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0133	0.0425	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Brugia malayi	protein unc-22	0.0108	0.0289	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus multilocularis	anosmin 1	0.0108	0.0289	0.0855
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0241	0.1002	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0108	0.0289	0.288
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.018	0.0677	0.5
Onchocerca volvulus		0.0133	0.0425	0.0151
Onchocerca volvulus		0.0133	0.0425	0.0151
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0133	0.0425	0.3202
Schistosoma mansoni	hypothetical protein	0.0108	0.0289	0.1597
Brugia malayi	hypothetical protein	0.0108	0.0289	0.0068
Schistosoma mansoni	titin	0.0108	0.0289	0.1597
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0241	0.1002	0.099
Schistosoma mansoni	hypothetical protein	0.0108	0.0289	0.1597
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0133	0.0425	0.0372
Brugia malayi	hypothetical protein	0.0108	0.0289	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	UNCoordinated family member	0.0108	0.0289	0.0226
Brugia malayi	Fibronectin type III domain containing protein	0.0108	0.0289	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0241	0.1002	1
Echinococcus multilocularis	titin	0.0108	0.0289	0.0855
Leishmania major	tyrosine specific protein phosphatase, putative	0.0133	0.0425	1
Brugia malayi	myotactin form B	0.0108	0.0289	0.0068
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Schistosoma mansoni	hemicentin	0.0108	0.0289	0.1597
Onchocerca volvulus		0.0133	0.0425	0.0151
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.2602
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.0108	0.0289	0.3288
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0241	0.1002	1
Echinococcus granulosus	anosmin 1	0.0108	0.0289	0.288
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0241	0.1002	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0241	0.1002	1
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Onchocerca volvulus		0.0133	0.0425	0.0151
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Brugia malayi	Fibronectin type III domain containing protein	0.0108	0.0289	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0133	0.0425	0.2602
Echinococcus granulosus	contactin	0.0108	0.0289	0.288
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0241	0.1002	1
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.2602
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0133	0.0425	0.2602
Brugia malayi	Lethal protein 805	0.0108	0.0289	0.0068
Echinococcus multilocularis	cell adhesion molecule	0.0108	0.0289	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0108	0.0289	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0174	0.0641	0.6392
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0133	0.0425	0.2602
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0108	0.0289	0.0226
Echinococcus multilocularis	usherin	0.0108	0.0289	0.0855
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Schistosoma mansoni	factor for adipocyte differentiation	0.0108	0.0289	0.1597
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.0108	0.0289	0.0068
Brugia malayi	hypothetical protein	0.0133	0.0425	0.0208
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Brugia malayi	Protein-tyrosine phosphatase	0.0133	0.0425	0.0208
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0108	0.0289	0.0855
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0133	0.0425	0.424
Brugia malayi	SPRY domain containing protein	0.0108	0.0289	0.0068
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Onchocerca volvulus		0.0133	0.0425	0.0151
Schistosoma mansoni	titin	0.0108	0.0289	0.1597
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0108	0.0289	0.288
Schistosoma mansoni	cell adhesion molecule	0.0108	0.0289	0.1597
Brugia malayi	WGR domain containing protein	0.0174	0.0641	0.0428
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.2602
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.424
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.2602
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0108	0.0289	0.0068
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus multilocularis	roundabout 2	0.0108	0.0289	0.0855
Brugia malayi	hypothetical protein	0.0133	0.0425	0.0208
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.424
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0241	0.1002	1
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0108	0.0289	0.0855
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.0108	0.0289	0.288
Brugia malayi	Lethal protein 805	0.0108	0.0289	0.0068
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Schistosoma mansoni	factor for adipocyte differentiation	0.0108	0.0289	0.1597
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0108	0.0289	0.0226
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0108	0.0289	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0241	0.1002	1
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0174	0.0641	1
Schistosoma mansoni	protein tyrosine phosphatase	0.0241	0.1002	1
Echinococcus multilocularis	Fibronectin, type III	0.0108	0.0289	0.0855
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0133	0.0425	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0133	0.0425	0.424
Brugia malayi	hypothetical protein	0.0133	0.0425	0.0208
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0133	0.0425	0.3202
Brugia malayi	Fibronectin type III domain containing protein	0.0108	0.0289	0.0068
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0133	0.0425	0.2602
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Onchocerca volvulus		0.0133	0.0425	0.0151
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0174	0.0641	0.5742
Schistosoma mansoni	myosin-binding protein-related	0.0108	0.0289	0.1597
Schistosoma mansoni	titin	0.0108	0.0289	0.1597
Trypanosoma cruzi	hypothetical protein, conserved	0.0108	0.0289	0.3288
Schistosoma mansoni	cell adhesion molecule	0.0108	0.0289	0.1597
Loa Loa (eye worm)	hypothetical protein	0.168	0.8709	0.9236
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0133	0.0425	0.0372
Echinococcus multilocularis	roundabout 2	0.0108	0.0289	0.0855
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0133	0.0425	0.3202
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.2602
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0241	0.1002	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0241	0.1002	1
Brugia malayi	Fibronectin type III domain containing protein	0.0108	0.0289	0.0068
Schistosoma mansoni	cell adhesion molecule	0.0108	0.0289	0.1597
Schistosoma mansoni	neuroglian	0.0108	0.0289	0.1597
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0222	0.0154
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0133	0.0425	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0241	0.1002	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus multilocularis	Netrin receptor DCC	0.0108	0.0289	0.0855
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0133	0.0425	0.424
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0133	0.0425	0.424
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0108	0.0289	0.0226
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0241	0.1002	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0108	0.0289	0.0226
Loa Loa (eye worm)	hypothetical protein	0.0133	0.0425	0.0372
Brugia malayi	hypothetical protein	0.0133	0.0425	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Onchocerca volvulus		0.1788	0.9286	1
Onchocerca volvulus		0.0133	0.0425	0.0151
Onchocerca volvulus		0.0133	0.0425	0.0151
Onchocerca volvulus		0.0133	0.0425	0.0151
Onchocerca volvulus		0.0133	0.0425	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0108	0.0289	0.0226
Echinococcus granulosus	usherin	0.0108	0.0289	0.288
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0133	0.0425	0.0372
Loa Loa (eye worm)	CAMK protein kinase	0.0108	0.0289	0.0226
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0133	0.0425	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0133	0.0425	0.0208

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.1 uM	Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assay	ChEMBL.	24398383
IC50 (functional)	= 17.24 uM	Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay	ChEMBL.	24398383

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	24398383

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3105885

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1821393