Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | poly (ADP-ribose) polymerase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CMGC family protein kinase | 0.0865 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0865 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0865 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0865 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0865 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0865 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0865 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0865 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0865 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0865 | 1 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0174 | 0.1621 | 0.1475 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0865 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0865 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.0673 | 0.0338 |
Brugia malayi | WGR domain containing protein | 0.0174 | 0.1621 | 0.1016 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0174 | 0.1621 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0865 | 1 | 1 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0095 | 0.0673 | 0.0673 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0865 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.1118 | 0.08 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0865 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0865 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0865 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0865 | 1 | 1 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0095 | 0.0673 | 0.0164 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0174 | 0.1621 | 0.1164 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0865 | 1 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0095 | 0.0673 | 0.0511 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0865 | 1 | 0.5 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0174 | 0.1621 | 0.1621 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 5 uM | Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assay | ChEMBL. | 24398383 |
IC50 (functional) | = 182.4 uM | Antiproliferative activity against BRCA1 gene mutated human HCC1937 cells after 72 hrs by SRB assay | ChEMBL. | 24398383 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.