Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | mitogen activated protein kinase | 0.0632 | 0.5 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0632 | 0.5 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0632 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0632 | 0.5 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0632 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0632 | 0.5 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0632 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0632 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0632 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0632 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0632 | 0.5 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0632 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0632 | 0.5 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0632 | 0.5 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0632 | 0.5 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0632 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0632 | 0.5 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0632 | 0.5 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0632 | 0.5 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0632 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 36 uM | Inhibition of Bacillus anthracis lethal factor assessed as MCA-KKVYPYPME[dnp]K amide cleavage after 30 mins by fluorescence plate reader analysis | ChEMBL. | 24290062 |
IC50 (binding) | = 79 uM | Inhibition of Clostridium bolulinum BoNT/A assessed as cleavage of MOCAc-Lys-Lys-Val-Tyr-Pro-Tyr-Pro-Met-Glu-Lys(Dnp)-NH2 after 40 mins by FRET assay | ChEMBL. | 24290062 |
IC50 (binding) | > 100 uM | Inhibition of human MMP-9 after 60 mins by FRET assay | ChEMBL. | 24290062 |
IC50 (binding) | > 100 uM | Inhibition of human MMP-1 after 60 mins by FRET assay | ChEMBL. | 24290062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.