Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0038 | 0.0496 | 0.1467 | |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.0621 | 0.1153 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0038 | 0.0496 | 0.0648 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0621 | 0.1153 |
Plasmodium vivax | vivapain-2 | 0.0038 | 0.0496 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0496 | 0.0922 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0931 | 0.0931 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0042 | 0.0621 | 0.1153 |
Brugia malayi | cathepsin L-like precursor | 0.0025 | 0.0158 | 0.0294 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0217 | 0.5382 | 0.5382 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0217 | 0.5382 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0217 | 0.5382 | 0.5382 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0042 | 0.0621 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0038 | 0.0496 | 0.1467 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0038 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0042 | 0.0621 | 0.0886 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0143 | 0.3374 | 0.6268 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0038 | 0.0496 | 0.0922 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.0496 | 0.7998 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0042 | 0.0621 | 0.1153 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0217 | 0.5382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1013 | 0.1637 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0621 | 0.1153 |
Loa Loa (eye worm) | ctsf protein | 0.0038 | 0.0496 | 0.0648 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Loa Loa (eye worm) | fibroinase | 0.0038 | 0.0496 | 0.0648 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0217 | 0.5382 | 0.5382 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0025 | 0.0158 | 0.2545 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0248 | 0.0462 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0025 | 0.0158 | 0.0294 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0038 | 0.0496 | 0.7998 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Brugia malayi | Cathepsin L-like precursor | 0.0025 | 0.0158 | 0.0294 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Leishmania major | cathepsin L-like protease | 0.0038 | 0.0496 | 0.0483 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0621 | 0.1153 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0248 | 0.5005 |
Leishmania major | cathepsin L-like protease | 0.0143 | 0.3374 | 0.6088 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0931 | 0.173 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0496 | 0.0922 |
Leishmania major | cathepsin L-like protease | 0.0038 | 0.0496 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0496 | 0.0648 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0217 | 0.5382 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0931 | 0.173 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0038 | 0.0496 | 0.0648 |
Echinococcus multilocularis | tumor protein p63 | 0.0386 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0248 | 0.5005 |
Toxoplasma gondii | cathepsin CPL | 0.0038 | 0.0496 | 0.0483 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0054 | 0.0931 | 0.1479 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0038 | 0.0496 | 1 |
Onchocerca volvulus | 0.0038 | 0.0496 | 0.1467 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0217 | 0.5382 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0217 | 0.5382 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0217 | 0.5382 | 1 |
Plasmodium vivax | vivapain-2 | 0.0038 | 0.0496 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0931 | 0.0931 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Schistosoma mansoni | alpha glucosidase | 0.0042 | 0.0621 | 0.1153 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Leishmania major | cathepsin L-like protease | 0.0143 | 0.3374 | 0.6088 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0038 | 0.0496 | 0.0496 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0217 | 0.5382 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.019 | 0.4647 | 0.8593 |
Schistosoma mansoni | alpha-glucosidase | 0.0163 | 0.3927 | 0.7295 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0248 | 0.0462 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0054 | 0.0931 | 0.173 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0038 | 0.0496 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0217 | 0.5382 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0038 | 0.0496 | 0.0922 |
Echinococcus multilocularis | cysteine protease | 0.0038 | 0.0496 | 0.0496 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0025 | 0.0158 | 0.0294 |
Entamoeba histolytica | cysteine protease, putative | 0.0038 | 0.0496 | 0.7998 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0054 | 0.0931 | 0.173 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0217 | 0.5382 | 1 |
Onchocerca volvulus | 0.0038 | 0.0496 | 0.1467 | |
Onchocerca volvulus | Cathepsin L homolog | 0.0038 | 0.0496 | 0.1467 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0042 | 0.0621 | 0.0725 |
Echinococcus granulosus | cathepsin l1 | 0.0038 | 0.0496 | 0.0496 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0217 | 0.5382 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0025 | 0.0158 | 0.0294 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0042 | 0.0621 | 0.0621 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 0.4647 | 0.4647 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0496 | 0.0922 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0621 | 0.1153 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0248 | 0.5005 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0143 | 0.3374 | 0.6268 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0621 | 0.1153 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0042 | 0.0621 | 1 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0038 | 0.0496 | 0.0496 |
Trypanosoma brucei | protein kinase, putative | 0.0217 | 0.5382 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0217 | 0.5382 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.0025 | 0.0158 | 0.0158 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0113 | 0.2539 | 0.4717 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0042 | 0.0621 | 0.1153 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0463 | 0.0583 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0217 | 0.5382 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.0496 | 0.0922 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0463 | 0.086 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0921 | 0.1711 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0054 | 0.0931 | 0.0931 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.019 | 0.4647 | 0.4647 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0921 | 0.1461 |
Onchocerca volvulus | 0.0057 | 0.1013 | 0.3707 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0025 | 0.0158 | 0.0294 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0496 | 0.0922 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0131 | 0.3035 | 0.564 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0038 | 0.0496 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0621 | 0.1153 |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0496 | 0.0922 |
Schistosoma mansoni | alpha-glucosidase | 0.0163 | 0.3927 | 0.7295 |
Onchocerca volvulus | 0.0038 | 0.0496 | 0.1467 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0921 | 0.1711 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0042 | 0.0621 | 0.0725 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0217 | 0.5382 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0038 | 0.0496 | 0.0496 |
Onchocerca volvulus | 0.011 | 0.2465 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0038 | 0.0496 | 0.0483 |
Trypanosoma brucei | glucosidase, putative | 0.0042 | 0.0621 | 0.1153 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0038 | 0.0496 | 0.0496 |
Brugia malayi | MAP kinase sur-1 | 0.0217 | 0.5382 | 1 |
Leishmania major | cathepsin L-like protease | 0.0038 | 0.0496 | 0.0483 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0028 | 0.0248 | 0.0462 |
Leishmania major | cathepsin L-like protease | 0.0143 | 0.3374 | 0.6088 |
Onchocerca volvulus | Cathepsin L homolog | 0.0038 | 0.0496 | 0.1467 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Echinococcus multilocularis | cysteine protease | 0.0038 | 0.0496 | 0.0496 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Leishmania major | cathepsin L-like protease | 0.0038 | 0.0496 | 0.0483 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Onchocerca volvulus | 0.0038 | 0.0496 | 0.1467 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0038 | 0.0496 | 0.0922 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0143 | 0.3374 | 0.6268 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0463 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Loa Loa (eye worm) | cysteine protease | 0.0038 | 0.0496 | 0.0648 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0217 | 0.5382 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0217 | 0.5382 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0038 | 0.0496 | 0.0922 |
Brugia malayi | Cathepsin L-like precursor | 0.0025 | 0.0158 | 0.0294 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0054 | 0.0931 | 0.0931 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0042 | 0.0621 | 0.1153 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0042 | 0.0621 | 0.0621 |
Leishmania major | cysteine peptidase A (CPA) | 0.0038 | 0.0496 | 0.0483 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0248 | 0.0173 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.019 | 0.4647 | 0.8634 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0921 | 0.1461 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0038 | 0.0496 | 0.0496 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0028 | 0.0248 | 0.0462 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0042 | 0.0621 | 0.1153 |
Onchocerca volvulus | 0.0038 | 0.0496 | 0.1467 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.019 | 0.4647 | 0.4647 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0143 | 0.3374 | 0.6268 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.1013 | 0.1883 |
Onchocerca volvulus | 0.0038 | 0.0496 | 0.1467 | |
Brugia malayi | Cathepsin L-like precursor | 0.0038 | 0.0496 | 0.0922 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0217 | 0.5382 | 0.5382 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0143 | 0.3374 | 0.6268 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 101 % | Induction of mushroom tyrosinase activity using L-tyrosine as substrate at 200 uM after 30 mins | ChEMBL. | 24433966 |
Activity (binding) | = 101.3 % | Induction of mushroom tyrosinase activity using L-DOPA as substrate at 50 uM after 30 mins | ChEMBL. | 24433966 |
Activity (binding) | = 101.8 % | Induction of mushroom tyrosinase activity using L-DOPA as substrate at 100 uM after 30 mins | ChEMBL. | 24433966 |
Activity (binding) | = 102.9 % | Induction of mushroom tyrosinase activity using L-DOPA as substrate at 200 uM after 30 mins | ChEMBL. | 24433966 |
Activity (binding) | = 104 % | Induction of mushroom tyrosinase activity using L-tyrosine as substrate at 50 uM after 30 mins | ChEMBL. | 24433966 |
Activity (binding) | = 104.5 % | Induction of mushroom tyrosinase activity using L-tyrosine as substrate at 100 uM after 30 mins | ChEMBL. | 24433966 |
Activity (ADMET) | = 105.3 % | Cytotoxicity against mouse B16F10 cells assessed as cell viability at 10 uM by MTT assay | ChEMBL. | 24433966 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.