Detailed information for compound 1821773

Basic information

Technical information
  • TDR Targets ID: 1821773
  • Name: 1-(3-chlorocarbazol-9-yl)-3-[4-(phenylmethyl) piperazin-1-yl]propan-2-ol
  • MW: 433.973 | Formula: C26H28ClN3O
  • H donors: 1 H acceptors: 1 LogP: 4.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(Cn1c2ccc(cc2c2c1cccc2)Cl)CN1CCN(CC1)Cc1ccccc1
  • InChi: 1S/C26H28ClN3O/c27-21-10-11-26-24(16-21)23-8-4-5-9-25(23)30(26)19-22(31)18-29-14-12-28(13-15-29)17-20-6-2-1-3-7-20/h1-11,16,22,31H,12-15,17-19H2
  • InChiKey: QPLPTHSTXJTSFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(3-chloro-9-carbazolyl)-3-[4-(phenylmethyl)-1-piperazinyl]propan-2-ol
  • 1-[4-(benzyl)piperazin-1-yl]-3-(3-chlorocarbazol-9-yl)propan-2-ol
  • Oprea1_119572

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0479 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0861 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0479 1 1
Brugia malayi MH2 domain containing protein 0.014 0.2683 0.2683
Loa Loa (eye worm) hypothetical protein 0.0037 0.0472 0.0472
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0479 1 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.3723 0.3723
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0479 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0861 0.0861
Schistosoma mansoni nuclear hormone receptor 0.0226 0.4541 0.4541
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0479 1 1
Brugia malayi conserved hypotetical protein 0.0226 0.4541 0.4541
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0036 0.0234
Echinococcus multilocularis thyroid hormone receptor alpha 0.0479 1 1
Mycobacterium ulcerans putative regulatory protein 0.0021 0.011 0.0894
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0226 0.4541 0.4541
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.9548 0.9548
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0166 0.3251 0.3251
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0479 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0861 1
Schistosoma mansoni hypothetical protein 0.0166 0.3256 0.3256
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.005 0.0743 0.936
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1267 0.1267
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0635 0.0635
Echinococcus multilocularis lipoxygenase domain containing protein 0.0037 0.0472 0.0472
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0676 0.0676
Brugia malayi PAS domain containing protein 0.0028 0.0266 0.0266
Brugia malayi ecdysone receptor 0.0226 0.4541 0.4541
Mycobacterium ulcerans aldehyde dehydrogenase 0.0055 0.0861 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0472 0.0472
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0479 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0479 1 1
Onchocerca volvulus 0.0479 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0253 0.5125 0.5125
Schistosoma mansoni zinc finger protein 0.0226 0.4541 0.4541
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0226 0.4541 0.4541
Schistosoma mansoni lipoxygenase 0.0099 0.1801 0.1801
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0676 0.0676
Echinococcus multilocularis FTZ F1 alpha 0.0479 1 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1267 0.1267
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0793 0.0793
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0793 0.0793
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Loa Loa (eye worm) nuclear hormone receptor 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0253 0.5125 0.5125
Plasmodium vivax hexose transporter 0.0052 0.0793 1
Schistosoma mansoni glucose transport protein 0.0052 0.0793 0.0793
Plasmodium falciparum histone acetyltransferase GCN5 0.0046 0.0653 0.8157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0479 1 1
Echinococcus multilocularis General substrate transporter 0.0045 0.0634 0.0634
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Echinococcus granulosus neuropeptide s receptor 0.0458 0.9548 0.9548
Loa Loa (eye worm) hypothetical protein 0.0093 0.1678 0.1678
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0479 1 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0479 1 1
Brugia malayi hypothetical protein 0.0226 0.4541 0.4541
Toxoplasma gondii aldehyde dehydrogenase 0.0055 0.0861 1
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.2683 0.2683
Echinococcus granulosus General substrate transporter 0.0045 0.0634 0.0634
Brugia malayi nuclear hormone receptor family member odr-7 0.0226 0.4541 0.4541
Echinococcus granulosus thyroid hormone receptor alpha 0.0226 0.4541 0.4541
Brugia malayi steroid hormone receptor 0.0479 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0226 0.4541 0.4541
Brugia malayi Nuclear hormone receptor-like 1 0.0253 0.5125 0.5125
Brugia malayi Nuclear hormone receptor E75 0.0226 0.4541 0.4541
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0635 0.0635
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0793 0.0793
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0052 0.0793 0.0793
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0479 1 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0057 0.0894 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0793 0.0793
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Trypanosoma brucei wee1-like protein kinase 0.0057 0.0894 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0166 0.3251 0.3251
Echinococcus granulosus Nuclear hormone receptor HR96 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Loa Loa (eye worm) acetyltransferase 0.017 0.3329 0.3329
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0036 0.0036
Echinococcus granulosus RUN 0.0037 0.0472 0.0472
Echinococcus granulosus FTZ F1 alpha 0.0479 1 1
Schistosoma mansoni hypothetical protein 0.0166 0.3256 0.3256
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0676 0.0676
Echinococcus multilocularis geminin 0.0166 0.3256 0.3256
Onchocerca volvulus 0.0226 0.4541 0.448
Brugia malayi Nuclear hormone receptor-like 1 0.0479 1 1
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0676 0.0676
Loa Loa (eye worm) hypothetical protein 0.0053 0.0816 0.0816
Schistosoma mansoni rab6-interacting 0.0037 0.0472 0.0472
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1267 0.1267
Onchocerca volvulus 0.0037 0.0472 0.0366
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.017 0.3329 0.3329
Onchocerca volvulus 0.0047 0.0676 0.0573
Brugia malayi Nuclear hormone receptor-like 1 0.0253 0.5125 0.5125
Echinococcus granulosus histone acetyltransferase KAT2B 0.005 0.0743 0.0743
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0036 0.0036
Plasmodium vivax histone acetyltransferase GCN5, putative 0.005 0.0743 0.9342
Echinococcus granulosus Polycystic kidney disease protein 0.0037 0.0472 0.0472
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1267 0.1267
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0816 0.0816
Loa Loa (eye worm) nuclear receptor NHR-67 0.0226 0.4541 0.4541
Brugia malayi hypoxia-induced factor 1 0.0086 0.1522 0.1522
Brugia malayi photoreceptor-specific nuclear receptor 0.0479 1 1
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0036 0.0265
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0226 0.4541 0.4541
Brugia malayi nuclear receptor RXR 0.0253 0.5125 0.5125
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0479 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0479 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0635 0.0635
Brugia malayi orphan nuclear receptor NR2E1 0.0226 0.4541 0.4541
Echinococcus multilocularis ecdysone induced protein 78C 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Schistosoma mansoni steroid hormone receptor ad4bp 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0055 0.0861 0.9623
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0226 0.4541 0.4541
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0226 0.4541 0.4541
Loa Loa (eye worm) TAR-binding protein 0.0074 0.1267 0.1267
Schistosoma mansoni nuclear receptor 0.0226 0.4541 0.4541
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0793 0.0793
Brugia malayi nuclear hormone receptor family member nhr-6 0.0226 0.4541 0.4541
Brugia malayi Sugar transporter family protein 0.0052 0.0793 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0793 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0226 0.4541 0.4541
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0479 1 1
Brugia malayi follicle stimulating hormone receptor 0.0232 0.4674 0.4674
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0226 0.4541 0.4541
Schistosoma mansoni polycystin 1-related 0.0037 0.0472 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0479 1 1
Brugia malayi TAR-binding protein 0.0074 0.1267 0.1267
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0479 1 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0816 0.0816
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Brugia malayi nuclear receptor NHR-88 0.0226 0.4541 0.4541
Schistosoma mansoni glucose transport protein 0.0052 0.0793 0.0793
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0816 0.0816
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0816 0.0816
Plasmodium vivax multidomain scavenger receptor, putative 0.0037 0.0472 0.5756
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0479 1 1
Brugia malayi mbt repeat family protein 0.0047 0.0676 0.0676
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0036 0.5
Echinococcus granulosus lipoxygenase domain containing protein 0.0037 0.0472 0.0472
Echinococcus multilocularis nuclear receptor nhr 48 0.0226 0.4541 0.4541
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.2683 0.2683
Toxoplasma gondii facilitative glucose transporter GT1 0.0052 0.0793 0.9176
Schistosoma mansoni thyroid hormone receptor 0.0479 1 1
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.9548 0.9548
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0057 0.0894 1
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.9548 0.9548
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.1267 0.1267
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0479 1 1
Schistosoma mansoni hypothetical protein 0.0288 0.5884 0.5884
Brugia malayi acetyltransferase, GNAT family protein 0.017 0.3329 0.3329
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0057 0.0894 1
Echinococcus granulosus ecdysone induced protein 78C 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0635 0.0635
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0479 1 1
Loa Loa (eye worm) sugar transporter 0.0052 0.0793 0.0793
Schistosoma mansoni rab6-interacting 0.0037 0.0472 0.0472
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0036 0.0036
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0057 0.0894 1
Loa Loa (eye worm) doublecortin family protein 0.0037 0.0472 0.0472
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0226 0.4541 0.448
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0635 0.0635
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0479 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.1267 0.1267
Onchocerca volvulus 0.0226 0.4541 0.448
Brugia malayi nuclear receptor NHR-67 0.0226 0.4541 0.4541
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0052 0.0793 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0479 1 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0037 0.0472 0.0472
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.017 0.3329 0.3329
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0479 1 1
Brugia malayi hypothetical protein 0.0253 0.5125 0.5125
Echinococcus multilocularis Polycystic kidney disease protein 0.0037 0.0472 0.0472
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0253 0.5125 0.5125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0036 0.0234
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0816 0.0816
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0388 0.0388
Schistosoma mansoni coup transcription factor 0.0479 1 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.4674 0.4674
Schistosoma mansoni nuclear receptor nhr-48 0.0226 0.4541 0.4541
Brugia malayi mbt repeat family protein 0.0047 0.0676 0.0676
Giardia lamblia Histone acetyltransferase GCN5 0.0046 0.0653 1
Onchocerca volvulus 0.0037 0.0472 0.0366
Schistosoma mansoni hypothetical protein 0.0033 0.0388 0.0388
Schistosoma mansoni lipoxygenase 0.0166 0.3251 0.3251
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0479 1 1
Brugia malayi tailless protein 0.0226 0.4541 0.4541
Schistosoma mansoni hypothetical protein 0.0052 0.0793 0.0793
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0635 0.0635
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0635 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0479 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0226 0.4541 0.4541
Schistosoma mansoni glucose transport protein 0.0052 0.0793 0.0793
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0479 1 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0676 0.0573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.5125 0.5125
Schistosoma mansoni nuclear hormone receptor 0.0479 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0479 1 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0722 0.0722
Schistosoma mansoni retinoic acid receptor RXR 0.0479 1 1
Brugia malayi RNA binding protein 0.0074 0.1267 0.1267
Plasmodium falciparum LCCL domain-containing protein 0.0037 0.0472 0.5756
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0036 0.5
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0676 0.0676
Brugia malayi hypothetical protein 0.0037 0.0472 0.0472
Loa Loa (eye worm) RNA binding protein 0.0074 0.1267 0.1267
Loa Loa (eye worm) hypothetical protein 0.0253 0.5125 0.5125
Entamoeba histolytica acetyltransferase, GNAT family 0.0046 0.0653 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0037 0.0472 0.0472
Brugia malayi bHLH-PAS transcription factor 0.0021 0.011 0.011
Loa Loa (eye worm) DR-78 0.0226 0.4541 0.4541
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0479 1 1
Loa Loa (eye worm) hypothetical protein 0.0479 1 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0479 1 1
Schistosoma mansoni thyroid hormone receptor 0.0479 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0472 0.0472
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0253 0.5125 0.5125
Loa Loa (eye worm) hypothetical protein 0.0253 0.5125 0.5125
Schistosoma mansoni nuclear receptor 0.0226 0.4541 0.4541
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0253 0.5125 0.5125
Echinococcus granulosus tar DNA binding protein 0.0074 0.1267 0.1267
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0479 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0055 0.0861 0.0861
Loa Loa (eye worm) hypothetical protein 0.0033 0.0388 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0074 0.1267 0.1267
Schistosoma mansoni aryl hydrocarbon receptor 0.0028 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0049 0.0722 0.0722
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0036 0.0234
Brugia malayi nuclear hormone receptor 0.0226 0.4541 0.4541
Brugia malayi hypothetical protein 0.0093 0.1678 0.1678
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0253 0.5125 0.5125
Loa Loa (eye worm) steroid hormone receptor 0.0479 1 1
Echinococcus multilocularis transfer RNA-Lys 0.0021 0.011 0.011
Brugia malayi nuclear hormone receptor 0.0479 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0479 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0479 1 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0052 0.0793 0.0793
Echinococcus granulosus Nuclear hormone receptor HR96 0.0226 0.4541 0.4541
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0036 0.0265
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0676 0.0676
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0635 0.0635
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0722 0.0722
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0055 0.0861 0.0861
Brugia malayi nuclear receptor RXR 0.0226 0.4541 0.4541
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0816 0.0816
Schistosoma mansoni nuclear hormone receptor 0.0226 0.4541 0.4541
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0676 0.0676
Echinococcus granulosus single minded 2 0.0021 0.011 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0479 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0479 1 1
Brugia malayi Doublecortin family protein 0.0037 0.0472 0.0472
Brugia malayi hypothetical protein 0.0037 0.0472 0.0472
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0055 0.0861 0.0861
Trichomonas vaginalis bromodomain-containing protein, putative 0.005 0.0743 0.936
Echinococcus granulosus geminin 0.0166 0.3256 0.3256
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0253 0.5125 0.5125
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.005 0.0743 0.8573
Brugia malayi hypothetical protein 0.0226 0.4541 0.4541
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0036 0.0234
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0479 1 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0036 0.0036
Schistosoma mansoni ap endonuclease 0.0017 0.0036 0.0036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0226 0.4541 0.4541
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0722 0.0722
Echinococcus multilocularis RUN 0.0037 0.0472 0.0472
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0479 1 1
Brugia malayi Steroid receptor seven-up type 2 0.0479 1 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0226 0.4541 0.4541
Echinococcus multilocularis tar DNA binding protein 0.0074 0.1267 0.1267
Echinococcus granulosus histone acetyltransferase KAT2B 0.0165 0.3226 0.3226
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0676 0.0676
Brugia malayi nuclear receptor NHR-88 0.0479 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0055 0.0861 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0676 0.0676
Brugia malayi hypothetical protein 0.0253 0.5125 0.5125
Brugia malayi Nuclear hormone receptor E75 0.0226 0.4541 0.4541
Schistosoma mansoni loxhd1 0.0037 0.0472 0.0472
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.3723 0.3723
Schistosoma mansoni RAR-like nuclear receptor 0.0479 1 1
Trypanosoma cruzi Wee1-like protein kinase, putative 0.0057 0.0894 1
Loa Loa (eye worm) MBCTL1 0.0053 0.0816 0.0816
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0226 0.4541 0.448
Schistosoma mansoni ap endonuclease 0.0017 0.0036 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0479 1 1
Schistosoma mansoni single-minded 0.0028 0.0266 0.0266
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.005 0.0743 0.8573
Loa Loa (eye worm) hypoxia-induced factor 1 0.0086 0.1522 0.1522
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0479 1 1
Plasmodium falciparum hexose transporter 0.0052 0.0793 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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