TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 344.357 | Formula: C16H24O8
H donors: 6 H acceptors: 6 LogP: -0.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 2
SMILES: OC[C@H]1O[C@@H](O[C@@H](CCc2ccc(cc2O)O)C)[C@@H]([C@H]([C@@H]1O)O)O
InChi: 1S/C16H24O8/c1-8(2-3-9-4-5-10(18)6-11(9)19)23-16-15(22)14(21)13(20)12(7-17)24-16/h4-6,8,12-22H,2-3,7H2,1H3/t8-,12-,13-,14+,15-,16-/m1/s1
InChiKey: XNCMTBXGJAVONM-XIXKKTEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tyrosinase	Starlite/ChEMBL	References
Agaricus bisporus	Tyrosinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	tyrosinase precursor	Get druggable targets OG5_137498	All targets in OG5_137498
Schistosoma mansoni	tyrosinase precursor	Get druggable targets OG5_137498	All targets in OG5_137498
Schistosoma japonicum	ko:K00505 tyrosinase [EC1.14.18.1], putative	Get druggable targets OG5_137498	All targets in OG5_137498
Schistosoma japonicum	ko:K00505 tyrosinase [EC1.14.18.1], putative	Get druggable targets OG5_137498	All targets in OG5_137498

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0222	0.3044	0.4309
Echinococcus granulosus	tyrosine protein kinase pr2	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Entamoeba histolytica	tyrosin kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	serine/threonine protein kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	slit	0.0053	0.0215	0.0215
Trichomonas vaginalis	conserved hypothetical protein	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0463	0.7063	1
Schistosoma mansoni	serine/threonine protein kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Echinococcus granulosus	epidermal growth factor receptor	0.0463	0.7063	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0309	0.0437
Echinococcus granulosus	kinase suppressor of Ras 1	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0463	0.7063	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0463	0.7063	1
Schistosoma mansoni	flightless-I	0.0053	0.0215	0.0215
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Onchocerca volvulus		0.0463	0.7063	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Echinococcus multilocularis	tyrosine protein kinase	0.0463	0.7063	1
Echinococcus granulosus	epidermal growth factor receptor	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0463	0.7063	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0463	0.7063	1
Schistosoma mansoni	serine/threonine protein kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Trypanosoma brucei	Pseudokinase, putative	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Onchocerca volvulus		0.0222	0.3044	0.4131
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0463	0.7063	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine kinase	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Entamoeba histolytica	receptor protein kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	c src tyrosine kinase	0.0463	0.7063	1
Trichomonas vaginalis	conserved hypothetical protein	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Echinococcus granulosus	natriuretic peptide receptor 1	0.0463	0.7063	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0463	0.7063	1
Brugia malayi	hypothetical protein	0.0053	0.0215	0.0304
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Loa Loa (eye worm)	TK/FAK protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Echinococcus granulosus	protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	serine/threonine protein kinase	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Giardia lamblia	Protein 21.1	0.0463	0.7063	1
Brugia malayi	Raf kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	tyrosin kinase, putative	0.0463	0.7063	0.8859
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Echinococcus multilocularis	protein tyrosine kinase	0.0463	0.7063	1
Leishmania major	hypothetical protein, conserved	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0463	0.7063	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0309	0.0437
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0463	0.7063	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0463	0.7063	0.7063
Brugia malayi	hypothetical protein	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Echinococcus granulosus	tyrosine protein kinase csk	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Trichomonas vaginalis	conserved hypothetical protein	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0463	0.7063	1
Echinococcus multilocularis	protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Schistosoma mansoni	ras suppressor protein 1 rsu1	0.0053	0.0215	0.0215
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0215	0.0304
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0463	0.7063	1
Brugia malayi	Guanylyl cyclase protein 23	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TK/RYK protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Leishmania major	protein kinase, putative	0.0463	0.7063	1
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Trypanosoma brucei	protein kinase, putative	0.0463	0.7063	1
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Leishmania major	protein kinase, putative	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Onchocerca volvulus		0.0463	0.7063	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	peroxidasin	0.0053	0.0215	0.0215
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0463	0.7063	1
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0222	0.3044	0.4309
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0463	0.7063	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Onchocerca volvulus		0.0222	0.3044	0.4131
Giardia lamblia	Kinase, NEK	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Brugia malayi	hypothetical protein	0.0463	0.7063	1
Echinococcus multilocularis	FL cytokine receptor	0.0463	0.7063	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.014	0.1669	0.2362
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	serine/threonine kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0053	0.0215	0.0304
Entamoeba histolytica	serine/threonine kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	leucine-rich repeat protein	0.0053	0.0215	0.0215
Onchocerca volvulus		0.0463	0.7063	1
Schistosoma mansoni	ras suppressor protein 1 rsu1	0.0053	0.0215	0.0215
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0463	0.7063	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	conserved hypothetical protein	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Brugia malayi	ShTK domain containing protein	0.0222	0.3044	0.4309
Schistosoma mansoni	ephrin receptor	0.0463	0.7063	0.7063
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Loa Loa (eye worm)	TK/EPH protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Loa Loa (eye worm)	ShTK domain-containing protein	0.0222	0.3044	0.4309
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0463	0.7063	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0463	0.7063	1
Loa Loa (eye worm)	sur-8-PB	0.0053	0.0215	0.0304
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0463	0.7063	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Echinococcus granulosus	integrin linked protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Schistosoma mansoni	leucine-rich repeat protein	0.0053	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0463	0.7063	0.8859
Echinococcus granulosus	tyrosine kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.7063	1
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0463	0.7063	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0463	0.7063	1
Echinococcus granulosus	tyrosine kinase	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0222	0.3044	0.4309
Brugia malayi	EGF-like domain containing protein	0.0053	0.0215	0.0304
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0463	0.7063	1
Trypanosoma cruzi	protein kinase, putative	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0463	0.7063	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Brugia malayi	SH2 domain containing protein	0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	tyrosin kinase, putative	0.0463	0.7063	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Brugia malayi	SH2 domain containing protein	0.0463	0.7063	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0463	0.7063	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Onchocerca volvulus		0.0222	0.3044	0.4131
Loa Loa (eye worm)	TK/CSK protein kinase	0.0463	0.7063	1
Brugia malayi	Common central domain of tyrosinase family protein	0.0222	0.3044	0.4309
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Onchocerca volvulus		0.0222	0.3044	0.4131
Echinococcus multilocularis	tyrosine protein kinase csk	0.0463	0.7063	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0463	0.7063	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Schistosoma mansoni	shoc2	0.0053	0.0215	0.0215
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0463	0.7063	0.7063
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	hypothetical protein, conserved	0.0463	0.7063	0.8859
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0053	0.0215	0.0304
Echinococcus granulosus	tyrosine protein kinase HCK	0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Echinococcus multilocularis	integrin linked protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0463	0.7063	1
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0222	0.3044	0.4309
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Brugia malayi	MH2 domain containing protein	0.014	0.1669	0.2362
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	shoc2	0.0053	0.0215	0.0215
Plasmodium falciparum	protein kinase, putative	0.0463	0.7063	1
Entamoeba histolytica	receptor protein kinase, putative	0.0463	0.7063	0.8859
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	SRC-1	0.0463	0.7063	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	PDZ-domain-containing protein scribble	0.0053	0.0215	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0516	0.7944	1
Onchocerca volvulus		0.0463	0.7063	1
Trichomonas vaginalis	conserved hypothetical protein	0.0463	0.7063	1
Schistosoma mansoni	variable lymphocyte receptor	0.0053	0.0215	0.0215
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	hypothetical protein	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Toxoplasma gondii	STE kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Onchocerca volvulus		0.0463	0.7063	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0463	0.7063	1
Plasmodium falciparum	protein kinase, putative	0.0463	0.7063	1
Echinococcus granulosus	activated cdc42 kinase 1	0.0463	0.7063	1
Echinococcus granulosus	tyrosine kinase	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Entamoeba histolytica	serine/threonine kinase, putative	0.0463	0.7063	0.8859
Toxoplasma gondii	protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	conserved hypothetical protein	0.0463	0.7063	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0516	0.7944	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Echinococcus granulosus	protein tyrosine kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0516	0.7944	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Brugia malayi	Furin-like cysteine rich region family protein	0.0463	0.7063	1
Brugia malayi	ras-binding protein SUR-8	0.0053	0.0215	0.0304
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	STE family protein kinase	0.0463	0.7063	1
Schistosoma mansoni	ephrin receptor	0.0463	0.7063	0.7063
Entamoeba histolytica	cysteine surface protein, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	protein kinase	0.0463	0.7063	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0463	0.7063	0.7063
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Brugia malayi	ras suppressor protein 1	0.0053	0.0215	0.0304
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0463	0.7063	0.7063
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.7063	1
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0222	0.3044	0.4309
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	Ras-binding protein SUR-8	0.0053	0.0215	0.0304
Loa Loa (eye worm)	TK/ROR protein kinase	0.0463	0.7063	1
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0463	0.7063	1
Brugia malayi	Peroxidasin	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Brugia malayi	integrin-linked kinase	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Echinococcus granulosus	c src tyrosine kinase	0.0463	0.7063	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0463	0.7063	1
Echinococcus granulosus	receptor type guanylyl cyclase	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Onchocerca volvulus		0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0463	0.7063	1
Brugia malayi	C-terminal src kinase protein 1	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0463	0.7063	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Brugia malayi	SRC-1	0.0463	0.7063	1
Onchocerca volvulus		0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Trichomonas vaginalis	AGC family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	tyrosin kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0463	0.7063	1
Echinococcus multilocularis	transfer RNA-Thr	0.0463	0.7063	1
Echinococcus granulosus	sodium channel protein	0.0152	0.1878	0.2429
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus granulosus	activin receptor type	0.0463	0.7063	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0463	0.7063	1
Schistosoma mansoni	shoc2	0.0053	0.0215	0.0215
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0463	0.7063	1
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Blk	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0516	0.7944	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	TK/DDR protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0222	0.3044	0.4309
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Brugia malayi	CCR4	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0463	0.7063	1
Echinococcus granulosus	insulin receptor	0.0463	0.7063	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0463	0.7063	0.8859
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	tyrosine protein kinase	0.0463	0.7063	0.7063
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0463	0.7063	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0463	0.7063	0.8859
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Plasmodium falciparum	tyrosine kinase-like protein	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0463	0.7063	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0463	0.7063	1
Schistosoma mansoni	tyrosinase precursor	0.0639	1	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0309	0.0437
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0152	0.1878	0.2429
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Schistosoma mansoni	slit	0.0053	0.0215	0.0215
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Brugia malayi	protein-tyrosine kinase	0.0463	0.7063	1
Schistosoma mansoni	protein tyrosine kinase	0.0463	0.7063	0.7063
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	insulin receptor	0.0463	0.7063	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0053	0.0215	0.0304
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Entamoeba histolytica	ankyrin repeat protein	0.0463	0.7063	0.8859
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0463	0.7063	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	tyrosinase 1	0.0222	0.3044	0.4309
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Brugia malayi	PDZ-domain protein scribble	0.0053	0.0215	0.0304
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0463	0.7063	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Echinococcus multilocularis	tyrosine protein kinase csk	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	conserved hypothetical protein	0.0463	0.7063	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0463	0.7063	1
Plasmodium vivax	protein kinase, putative	0.0463	0.7063	1
Trichomonas vaginalis	TK family protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0463	0.7063	1
Trichomonas vaginalis	CAMK family protein kinase	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0463	0.7063	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Echinococcus multilocularis	activated cdc42 kinase 1	0.0463	0.7063	1
Giardia lamblia	Kinase, NEK	0.0463	0.7063	1
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0463	0.7063	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Trypanosoma cruzi	protein kinase, putative	0.0463	0.7063	1
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0463	0.7063	0.7063
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.0053	0.0215	0.0304
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0516	0.7944	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0463	0.7063	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0463	0.7063	1
Brugia malayi	hypothetical protein	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0463	0.7063	1
Echinococcus multilocularis	heat shock protein 70	0.0463	0.7063	1
Schistosoma mansoni	serine/threonine RGC	0.0463	0.7063	0.7063
Loa Loa (eye worm)	TK/FER protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Echinococcus granulosus	ephrin type A receptor 4 A	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0463	0.7063	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	transcription factor SMAD2	0.014	0.1669	0.2362
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Plasmodium falciparum	tyrosine kinase-like protein	0.0463	0.7063	1
Schistosoma mansoni	protein phosphatases pp1 regulatory subunit	0.0053	0.0215	0.0215
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Brugia malayi	ephrin receptor 1 precursor	0.0463	0.7063	1
Entamoeba histolytica	hypothetical protein	0.0463	0.7063	0.8859
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0222	0.3044	0.4309
Echinococcus multilocularis	sodium channel protein	0.0152	0.1878	0.2429
Entamoeba histolytica	ankyrin repeat protein	0.0463	0.7063	0.8859
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0152	0.1878	0.2429
Entamoeba histolytica	tyrosine kinase, putative	0.0463	0.7063	0.8859
Echinococcus granulosus	tyrosine protein kinase Srms	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0463	0.7063	1
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Onchocerca volvulus		0.0463	0.7063	1
Brugia malayi	Leucine Rich Repeat family protein	0.0053	0.0215	0.0304
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0463	0.7063	1
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Loa Loa (eye worm)	TK protein kinase	0.0463	0.7063	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0463	0.7063	1
Plasmodium falciparum	protein kinase, putative	0.0463	0.7063	1
Schistosoma mansoni	serine/threonine protein kinase	0.0463	0.7063	0.7063
Schistosoma mansoni	protein kinase	0.0463	0.7063	0.7063
Giardia lamblia	Kinase	0.0463	0.7063	1
Entamoeba histolytica	protein kinase, putative	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Entamoeba histolytica	protein kinase domain containing protein	0.0463	0.7063	0.8859
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0309	0.0437
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Schistosoma mansoni	tyrosine kinase	0.0463	0.7063	0.7063
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0053	0.0215	0.0304
Echinococcus multilocularis	activin receptor type	0.0463	0.7063	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0463	0.7063	0.7063
Brugia malayi	Protein kinase domain containing protein	0.0463	0.7063	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0463	0.7063	1
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0215	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0463	0.7063	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0463	0.7063	1
Schistosoma mansoni	hypothetical protein	0.0053	0.0215	0.0215
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0463	0.7063	1
Loa Loa (eye worm)	leucine Rich Repeat family protein	0.0053	0.0215	0.0304

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 2.3 uM	Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as dopachrome formation after 5 mins by spectrophotometry	ChEMBL.	24332496
IC50 (binding)	= 2.3 uM	Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysis	ChEMBL.	26386819

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3100132

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1821882