Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin-dependent kinase 3 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | cyclin-dependent kinase 3 | 305 aa | 303 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Niemann Pick C1 protein | 0.0831 | 0.3963 | 0.3961 |
Schistosoma mansoni | patched 1 | 0.0831 | 0.3963 | 0.3961 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.072 | 0.0717 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0947 | 0.4552 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.072 | 0.0717 |
Echinococcus multilocularis | protein patched | 0.0831 | 0.3963 | 0.3961 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2019 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0831 | 0.3963 | 0.8704 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.2019 | 1 | 1 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0003 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0947 | 0.4552 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2019 | 1 | 1 |
Echinococcus granulosus | geminin | 0.0193 | 0.072 | 0.0717 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2019 | 1 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0831 | 0.3963 | 0.3961 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0831 | 0.3963 | 0.3961 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0052 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0003 | 0.0003 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.2019 | 1 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0831 | 0.3963 | 0.3961 |
Plasmodium vivax | protein kinase Crk2 | 0.0052 | 0.0003 | 0.5 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0052 | 0.0003 | 0.0003 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0947 | 0.4552 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0831 | 0.3963 | 0.3961 |
Brugia malayi | CHE-14 protein | 0.0831 | 0.3963 | 0.3961 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0831 | 0.3963 | 0.3961 |
Echinococcus multilocularis | geminin | 0.0193 | 0.072 | 0.0717 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0831 | 0.3963 | 0.3961 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.0052 | 0.0003 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0831 | 0.3963 | 0.3963 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0947 | 0.4552 | 1 |
Plasmodium falciparum | protein kinase 5 | 0.0052 | 0.0003 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.2019 | 1 | 1 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.0052 | 0.0003 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.2019 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0831 | 0.3963 | 0.3963 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 uM | Inhibition of cyclin-dependent kinase 1 | ChEMBL. | 11063606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.