TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 270.33 | Formula: C15H18N4O
H donors: 2 H acceptors: 2 LogP: 2.2 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ncc[nH]1)Nc1ccccc1N1CCCCC1
InChi: 1S/C15H18N4O/c20-15(14-16-8-9-17-14)18-12-6-2-3-7-13(12)19-10-4-1-5-11-19/h2-3,6-9H,1,4-5,10-11H2,(H,16,17)(H,18,20)
InChiKey: NWRWDHNONGEXRD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	Pim-2 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	Pim-3 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	protein lipid droplet kinase (LDK)	Pim-3 proto-oncogene, serine/threonine kinase	326 aa	296 aa	29.7 %
Trypanosoma brucei	protein lipid droplet kinase (LDK)	Pim-2 proto-oncogene, serine/threonine kinase	311 aa	278 aa	28.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	natriuretic peptide receptor 1	0.0525	0.6997	0.9882
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0525	0.6997	0.9882
Echinococcus granulosus	activin receptor type	0.0527	0.7081	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	activated cdc42 kinase 1	0.0525	0.6997	0.9882
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Giardia lamblia	Protein 21.1	0.0525	0.6997	0.5
Echinococcus multilocularis	tyrosine protein kinase csk	0.0525	0.6997	0.9882
Echinococcus granulosus	integrin linked protein kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0525	0.6997	0.9882
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0525	0.6997	1
Schistosoma mansoni	protein kinase	0.0527	0.7081	1
Schistosoma mansoni	hypothetical protein	0.0525	0.6997	0.9882
Onchocerca volvulus		0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0525	0.6997	0.9882
Trichomonas vaginalis	protein kinase atn1, putative	0.0525	0.6997	0.5
Echinococcus multilocularis	insulin receptor	0.0525	0.6997	0.9882
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0525	0.6997	0.9882
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0525	0.6997	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0525	0.6997	1
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase csk	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0525	0.6997	0.5
Brugia malayi	Raf kinase	0.0525	0.6997	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Echinococcus granulosus	c src tyrosine kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	CAMK family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0527	0.7081	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0525	0.6997	0.9882
Echinococcus multilocularis	FL cytokine receptor	0.0525	0.6997	0.9882
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0525	0.6997	0.9882
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	serine/threonine protein kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0525	0.6997	0.9882
Echinococcus granulosus	receptor type guanylyl cyclase	0.0525	0.6997	0.9882
Brugia malayi	Furin-like cysteine rich region family protein	0.0525	0.6997	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	protein-tyrosine kinase	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Onchocerca volvulus		0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0525	0.6997	0.9882
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0525	0.6997	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase	0.0525	0.6997	0.9882
Giardia lamblia	Kinase, NEK	0.0525	0.6997	0.5
Echinococcus multilocularis	transfer RNA-Thr	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Schistosoma mansoni	serine/threonine protein kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.6997	0.5
Loa Loa (eye worm)	SRC-1	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0525	0.6997	0.9882
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0527	0.7081	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Onchocerca volvulus		0.0525	0.6997	1
Echinococcus multilocularis	integrin linked protein kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	raf serine:threonine protein kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/RYK protein kinase	0.0525	0.6997	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0525	0.6997	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/Met protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK/CSK protein kinase	0.0525	0.6997	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Onchocerca volvulus		0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	protein tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase Srms	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase shark	0.0525	0.6997	0.9882
Echinococcus granulosus	epidermal growth factor receptor	0.0525	0.6997	0.9882
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0525	0.6997	0.9882
Entamoeba histolytica	protein kinase domain containing protein	0.0527	0.7081	0.0279
Echinococcus granulosus	activated cdc42 kinase 1	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0525	0.6997	0.9882
Echinococcus granulosus	insulin receptor	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	protein kinase	0.0527	0.7081	1
Entamoeba histolytica	hypothetical protein	0.0585	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/DDR protein kinase	0.0525	0.6997	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0525	0.6997	0.9882
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Giardia lamblia	Kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Onchocerca volvulus	Tyrosine kinase homolog	0.0525	0.6997	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0525	0.6997	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0525	0.6997	1
Trypanosoma brucei	protein kinase, putative	0.0527	0.7081	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	AGC family protein kinase	0.0525	0.6997	0.5
Brugia malayi	hypothetical protein	0.0525	0.6997	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0525	0.6997	0.9882
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	serine/threonine protein kinase	0.0525	0.6997	1
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0525	0.6997	1
Schistosoma mansoni	ephrin receptor	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Brugia malayi	Tyrosine-protein kinase PR2	0.0525	0.6997	1
Brugia malayi	integrin-linked kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0525	0.6997	0.9882
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0525	0.6997	0.9882
Brugia malayi	ephrin receptor 1 precursor	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0525	0.6997	0.9882
Brugia malayi	SRC-1	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Echinococcus granulosus	kinase suppressor of Ras 1	0.0525	0.6997	0.9882
Brugia malayi	C-terminal src kinase protein 1	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Entamoeba histolytica	protein kinase, putative	0.0585	1	1
Echinococcus multilocularis	heat shock protein 70	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine kinase	0.0525	0.6997	0.9882
Onchocerca volvulus		0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.6997	0.5
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Echinococcus granulosus	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	activin receptor type	0.0527	0.7081	1
Giardia lamblia	Kinase, NEK	0.0525	0.6997	0.5
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0525	0.6997	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0525	0.6997	0.9882
Schistosoma mansoni	protein kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	hypothetical protein	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0525	0.6997	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0585	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0525	0.6997	1
Echinococcus granulosus	epidermal growth factor receptor	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0527	0.7081	1
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/ABL protein kinase	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	protein kinase	0.0527	0.7081	1
Schistosoma mansoni	protein tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0525	0.6997	0.9882
Brugia malayi	Guanylyl cyclase protein 23	0.0525	0.6997	1
Schistosoma mansoni	serine/threonine protein kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	STE family protein kinase	0.0525	0.6997	0.5
Leishmania major	protein kinase, putative	0.0527	0.7081	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0525	0.6997	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0527	0.7081	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0525	0.6997	0.9882
Echinococcus multilocularis	epidermal growth factor receptor	0.0525	0.6997	0.9882
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Onchocerca volvulus		0.0525	0.6997	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TK family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Plasmodium vivax	protein kinase, putative	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	hypothetical protein	0.0525	0.6997	1
Onchocerca volvulus		0.0525	0.6997	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0525	0.6997	0.9882
Echinococcus multilocularis	c src tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0525	0.6997	0.9882
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Trichomonas vaginalis	conserved hypothetical protein	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0527	0.7081	1
Plasmodium falciparum	protein kinase, putative	0.0527	0.7081	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	ephrin receptor	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/EPH protein kinase	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0525	0.6997	0.9882
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0525	0.6997	0.5
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0525	0.6997	1
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0525	0.6997	0.9882
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0527	0.7081	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase Blk	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0525	0.6997	0.9882
Echinococcus granulosus	protein tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase csk	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0525	0.6997	0.9882
Entamoeba histolytica	hypothetical protein	0.0585	1	1
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase shark	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0525	0.6997	0.9882
Loa Loa (eye worm)	hypothetical protein	0.0525	0.6997	1
Echinococcus granulosus	protein kinase	0.0525	0.6997	0.9882
Echinococcus multilocularis	tyrosine kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK protein kinase	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0525	0.6997	0.9882
Echinococcus multilocularis	protein kinase	0.0525	0.6997	0.9882
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/FAK protein kinase	0.0525	0.6997	1
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0525	0.6997	0.9882
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0525	0.6997	0.5
Onchocerca volvulus		0.0525	0.6997	1
Echinococcus multilocularis	protein kinase	0.0525	0.6997	0.9882
Echinococcus granulosus	ephrin type A receptor 4 A	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	serine/threonine RGC	0.0525	0.6997	0.9882
Echinococcus multilocularis	activated cdc42 kinase 1	0.0525	0.6997	0.9882
Brugia malayi	SH2 domain containing protein	0.0525	0.6997	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0525	0.6997	0.9882
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0525	0.6997	0.9882
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Brugia malayi	Protein kinase domain containing protein	0.0525	0.6997	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0527	0.7081	1
Echinococcus granulosus	tyrosine kinase	0.0525	0.6997	0.9882
Brugia malayi	SH2 domain containing protein	0.0525	0.6997	1
Trichomonas vaginalis	TKL family protein kinase	0.0525	0.6997	0.5
Schistosoma mansoni	tyrosine kinase	0.0525	0.6997	0.9882
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0525	0.6997	0.9882
Loa Loa (eye worm)	TK/FER protein kinase	0.0525	0.6997	1
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0525	0.6997	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0525	0.6997	0.9882
Brugia malayi	Tyrosine-protein kinase abl-1	0.0525	0.6997	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	> 12500 nM	Inhibition of PIM3 (unknown origin)	ChEMBL.	24900629
Ki (binding)	> 12500 nM	Inhibition of PIM2 (unknown origin)	ChEMBL.	24900629
Ki (binding)	> 12500 nM	Inhibition of PIM1 (unknown origin)	ChEMBL.	24900629

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3103870

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1821966