Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | perforin 1 (pore forming protein) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1152 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1152 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1152 | 1 | 1 |
Onchocerca volvulus | 0.1152 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.1071 | 0.1071 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1152 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0609 | 0.1071 | 0.1071 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1152 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.1152 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1152 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0609 | 0.1071 | 0.1071 |
Brugia malayi | nuclear receptor NHR-88 | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.1071 | 0.1071 |
Schistosoma mansoni | nuclear hormone receptor | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.1071 | 0.1071 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1152 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0609 | 0.1071 | 0.1071 |
Brugia malayi | nuclear hormone receptor | 0.1152 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1152 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1152 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1152 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1152 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1152 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1152 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1152 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0609 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1152 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1152 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1152 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0609 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0609 | 0.1071 | 0.1071 |
Schistosoma mansoni | thyroid hormone receptor | 0.1152 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0609 | 0.1071 | 0.1071 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1152 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1152 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1152 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0609 | 0.1071 | 0.1071 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1152 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0609 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1152 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1152 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0609 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1152 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1152 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1152 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1152 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1152 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0609 | 0.1071 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.1152 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1152 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1152 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.1152 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1152 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1152 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1152 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1152 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1152 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.64 uM | Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated for 30 mins followed by addition of cells measured after 4 hrs by gamma counting analysis | ChEMBL. | 24195776 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.